Related papers: A Multi-Scale Simulation of Retinal Physiology
Mathematical modelling of the microcirculatory hemodynamics in the retina is an essential tool for understanding various diseases of the retina, yet remains challenging due to the multiscale nature of the retinal vasculature and its…
We present an optimized conductance-based retina microcircuit simulator which transforms light stimuli into a series of graded and spiking action potentials through photo transduction. We use discrete retinal neuron blocks based on a…
Implementing accurate models of the retina is a challenging task, particularly in the context of creating visual prosthetics and devices. Notwithstanding the presence of diverse artificial renditions of the retina, the imperative task…
The evaluation and monitoring of cells health in the human retina is crucial and follow time course of retinal diseases, detect lesions before irreversible visual loss and to evaluate treatment effects. Towards this goal, a major challenge…
With a kind of magnetism, the human retina draws the eye of neuroscientist and physicist alike. It is attractive as a self-organizing system, which forms as a part of the central nervous system via biochemical and mechanical cues. The…
This paper is an introduction to the membrane potential equation for neurons. Its properties are described, as well as sample applications. Networks of these equations can be used for modeling neuronal systems, which also process images and…
We present a method based on a time domain simulation of wave propagation that allows studying the optical response of a broad range of dielectric photonic structures. This method is particularly suitable for dealing with complex biological…
Neural circuits in the retina divide the incoming visual scene into more than a dozen distinct representations that are sent on to central brain areas, such as the lateral geniculate nucleus and the superior colliculus. The retina can be…
We developed Macular, a simulation platform with a graphical interface, designed to produce in silico experiment scenarios for the retina and the primary visual system. A scenario consists of generating a three-dimensional structure with…
Two computational models to be used as tools for experimental research on the retinal implant are presented. In the first model, the electric field produced by a multi-electrode array in a uniform retina is calculated. In the second model,…
The health of cells found in the inner retinal layers of the human eye is crucial to understand the onset of diseases of the retina such as macular degeneration and retinopathy. A challenge is to periodically image these cells in human eyes…
There exists a large body of research on the lens of mammalian eye over the past several decades. The objective of the current work is to provide a link between the most recent computational models to some of the pioneering work in the…
We present a fiber-distributed model of the reinforcing collagen of the human cornea. The model describes the basic connections between the components of the tissue by defining an elementary block (cell) and upscaling it to the physical…
With this paper we propose a model to simulate the functional aspects of light adaptation in retinal photoreceptors. Our model, however, does not link specific stages to the detailed molecular processes which are thought to mediate…
The retina is the entrance of the visual system. Although based on common biophysical principles the dynamics of retinal neurons is quite different from their cortical counterparts, raising interesting problems for modellers. In this paper…
Currently, free flaps and pedicled flaps are assessed for reperfusion in post-operative care using colour, capillary refill, temperature, texture and Doppler signal (if available). While these techniques are effective, they are prone to…
Nanophotonic structures have versatile applications including solar cells, anti-reflective coatings, electromagnetic interference shielding, optical filters, and light emitting diodes. To design and understand these nanophotonic structures,…
Over the last decade, a variety of new neurophysiological experiments have led to new insights as to how, when and where retinal processing takes place, and the nature of the retinal representation encoding sent to the cortex for further…
The mini-review gives special attention to holistic approach and mechanisms of processes. The physical and chemical frames and background for visual perception and signalling are discussed. Perception of photons by retinal rod cells is…
The cardiovascular and ocular systems are intricately connected, with hemodynamic interactions playing a crucial role in both physiological regulation and pathological conditions. However, existing models often treat these systems…