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In recent years, real-world external controls have grown in popularity as a tool to empower randomized placebo-controlled trials, particularly in rare diseases or cases where balanced randomization is unethical or impractical. However, as…

Methodology · Statistics 2024-11-14 Chenyin Gao , Shu Yang , Mingyang Shan , Wenyu Ye , Ilya Lipkovich , Douglas Faries

Black-box optimization is often encountered for decision-making in complex systems management, where the knowledge of system is limited. Under these circumstances, it is essential to balance the utilization of new information with…

Computation · Statistics 2025-01-15 Teng Lian , Jian-Qiang Hu , Yuhang Wu , Zeyu Zheng

We argue that the estimation of mutual information between high dimensional continuous random variables can be achieved by gradient descent over neural networks. We present a Mutual Information Neural Estimator (MINE) that is linearly…

Bayesian optimization (BO) is an efficient framework for solving black-box optimization problems with expensive function evaluations. This paper addresses the BO problem setting for combinatorial spaces (e.g., sequences and graphs) that…

Machine Learning · Computer Science 2022-02-07 Aryan Deshwal , Syrine Belakaria , Janardhan Rao Doppa

Supervised, semi-supervised, and unsupervised learning estimate a function given input/output samples. Generalization of the learned function to unseen data can be improved by incorporating side information into learning. Side information…

Machine Learning · Computer Science 2016-02-11 Rico Jonschkowski , Sebastian Höfer , Oliver Brock

The information bottleneck principle is an elegant and useful approach to representation learning. In this paper, we investigate the problem of representation learning in the context of reinforcement learning using the information…

Machine Learning · Computer Science 2019-11-14 Pei Yingjun , Hou Xinwen

We consider dimension reduction of multiview data, which are emerging in scientific studies. Formulating multiview data as multi-variate data with block structures corresponding to the different views, or views of data, we estimate top…

Methodology · Statistics 2024-06-18 Lin Xiao , Luo Xiao

Observational cohort studies are increasingly being used for comparative effectiveness research to assess the safety of therapeutics. Recently, various doubly robust methods have been proposed for average treatment effect estimation by…

Methodology · Statistics 2025-03-11 Xiaoqing Tan , Shu Yang , Wenyu Ye , Douglas E. Faries , Ilya Lipkovich , Zbigniew Kadziola

Existing statistical methods for the analysis of micro-randomized trials (MRTs) are designed to estimate causal excursion effects using data from a single MRT. In practice, however, researchers can often find previous MRTs that employ…

Methodology · Statistics 2025-05-13 Easton Huch , Inbal Nahum-Shani , Lindsey Potter , Cho Lam , David W. Wetter , Walter Dempsey

Rapid advancements in data science require us to have fundamentally new frameworks to tackle prevalent but highly non-trivial "irregular" inference problems, to which the large sample central limit theorem does not apply. Typical examples…

Methodology · Statistics 2026-02-11 Minge Xie , Peng Wang

Large sample behavior of dynamic information borrowing (DIB) estimators is investigated. Asymptotic properties of several DIB approaches (adaptive risk minimization, adaptive LASSO, Bayesian procedures with empirical power prior, fully…

Methodology · Statistics 2025-03-03 Sergey Tarima , Silvia Calderazzo , Mary Homan

In a randomised clinical trial, when the result of the primary endpoint shows a significant benefit, the secondary endpoints are scrutinised to identify additional effects of the treatment. However, this approach entails a risk of…

The importance of finding the characteristics leading to either a success or a failure is one of the driving forces of data mining. The various application areas of finding success/failure factors cover vast variety of areas such as credit…

Databases · Computer Science 2010-02-08 Yuval Cohen

Sequentially, the systematic processing of a significant amount of data can be necessary for input datasets to get desired outputs. In a workflow management system(WMS), usually, users build workflows by manually selecting and…

Networking and Internet Architecture · Computer Science 2022-02-15 Debasish Chakroborti

Recommender systems (RSs) provide an effective way of alleviating the information overload problem by selecting personalized choices. Online social networks and user-generated content provide diverse sources for recommendation beyond…

Information Retrieval · Computer Science 2020-10-19 Guang-Neng Hu , Xin-Yu Dai , Yunya Song , Shu-Jian Huang , Jia-Jun Chen

Nowadays, algorithms with fast convergence, small memory footprints, and low per-iteration complexity are particularly favorable for artificial intelligence applications. In this paper, we propose a doubly stochastic algorithm with a novel…

Machine Learning · Computer Science 2023-04-25 Zebang Shen , Hui Qian , Tongzhou Mu , Chao Zhang

Many real-world tasks require optimizing expensive black-box functions accessible only through noisy evaluations, a setting commonly addressed with Bayesian optimization (BO). While Bayesian neural networks (BNNs) have recently emerged as…

Machine Learning · Computer Science 2026-01-14 Farhad Mirkarimi

Learning about causal effects in target populations and their subsets may be facilitated by combining information from multiple sources. One major class of study designs that combine information involves appending an index study with data…

When considering the effect a treatment will cause in a population of interest, we often look to evidence from randomized controlled trials. In settings where multiple trials on a treatment are available, we may wish to synthesize the…

Methodology · Statistics 2023-09-08 Nicole Schnitzler , Eloise Kaizar

Complex computer simulations are commonly required for accurate data modelling in many scientific disciplines, making statistical inference challenging due to the intractability of the likelihood evaluation for the observed data.…

Machine Learning · Statistics 2019-10-02 Pablo de Castro , Tommaso Dorigo