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As artificial intelligence (AI) becomes increasingly embedded in healthcare delivery, this chapter explores the critical aspects of developing reliable and ethical Clinical Decision Support Systems (CDSS). Beginning with the fundamental…

Artificial Intelligence · Computer Science 2025-02-18 Muhammet Alkan , Idris Zakariyya , Samuel Leighton , Kaushik Bhargav Sivangi , Christos Anagnostopoulos , Fani Deligianni

This research focuses on evaluating and enhancing data readiness for the development of an Artificial Intelligence (AI)-based Clinical Decision Support System (CDSS) in the context of skin cancer treatment. The study, conducted at the Skin…

Artificial Intelligence · Computer Science 2025-03-13 Joscha Grüger , Tobias Geyer , Tobias Brix , Michael Storck , Sonja Leson , Laura Bley , Carsten Weishaupt , Ralph Bergmann , Stephan A. Braun

As cannabis use has increased in recent years, researchers have come to rely on sophisticated machine learning models to predict cannabis use behavior and its impact on health. However, many artificial intelligence (AI) models lack…

Human-Computer Interaction · Computer Science 2025-03-11 Tongze Zhang , Tammy Chung , Anind Dey , Sang Won Bae

Major depressive disorder is a debilitating disease affecting 264 million people worldwide. While many antidepressant medications are available, few clinical guidelines support choosing among them. Decision support tools (DSTs) embodying…

This research paper outlines the development and implementation of a novel Clinical Decision Support System (CDSS) that integrates AI predictive modeling with medical knowledge bases. It utilizes the quantifiable information elements in lab…

Artificial Intelligence · Computer Science 2026-03-17 Muhammad Hammad Maqsood , Mubashir Sajid , Khubaib Ahmed , Muhammad Usamah Shahid , Muddassar Farooq

Identifying type 2 diabetes mellitus can be challenging, particularly for primary care physicians. Clinical decision support systems incorporating artificial intelligence (AI-CDSS) can assist medical professionals in diagnosing type 2…

Machine Learning · Computer Science 2026-02-13 Mujeeb Ur Rehman , Imran Rehan , Sohail Khalid

Artificial intelligence (AI) technology has been increasingly used in the implementation of advanced Clinical Decision Support Systems (CDSS). Research demonstrated the potential usefulness of AI-powered CDSS (AI-CDSS) in clinical decision…

Human-Computer Interaction · Computer Science 2021-01-14 Dakuo Wang , Liuping Wang , Zhan Zhang , Ding Wang , Haiyi Zhu , Yvonne Gao , Xiangmin Fan , Feng Tian

Artificial Intelligence (AI) has demonstrated potential in healthcare, particularly in enhancing diagnostic accuracy and decision-making through Clinical Decision Support Systems (CDSSs). However, the successful implementation of these…

Human-Computer Interaction · Computer Science 2025-01-29 Olya Rezaeian , Alparslan Emrah Bayrak , Onur Asan

Clinical decision support systems (CDSS) are widely used to assist with medical decision making. However, CDSS typically require manually curated rules and other data which are difficult to maintain and keep up-to-date. Recent systems…

Human-Computer Interaction · Computer Science 2020-11-20 Zhuochen Jin , Jingshun Yang , Shuyuan Cui , David Gotz , Jimeng Sun , Nan Cao

Mental health disorders are rising worldwide. However, the availability of trained clinicians has not scaled proportionally, leaving many people without adequate or timely support. To bridge this gap, recent studies have shown the promise…

Computation and Language · Computer Science 2025-08-19 Aishik Mandal , Prottay Kumar Adhikary , Hiba Arnaout , Iryna Gurevych , Tanmoy Chakraborty

This study reports the findings of qualitative interview sessions conducted with ICU clinicians for the co-design of a system user interface of an artificial intelligence (AI)-driven clinical decision support (CDS) system. This system…

Human-Computer Interaction · Computer Science 2025-03-13 Andrea E. Davidson , Jessica M. Ray , Ayush K. Patel , Yulia Strekalova Levites , Parisa Rashidi , Azra Bihorac

The COVID-19 crisis has brought about new clinical questions, new workflows, and accelerated distributed healthcare needs. While artificial intelligence (AI)-based clinical decision support seemed to have matured, the application of…

Computers and Society · Computer Science 2020-06-08 Mathias Unberath , Kimia Ghobadi , Scott Levin , Jeremiah Hinson , Gregory D Hager

As AI-based clinical decision support (AI-CDS) is introduced in more and more aspects of healthcare services, HCI research plays an increasingly important role in designing for complementarity between AI and clinicians. However, current…

Human-Computer Interaction · Computer Science 2025-04-11 Venkatesh Sivaraman , Katelyn Morrison , Will Epperson , Adam Perer

Artificial intelligence (AI) in healthcare has the potential to improve patient outcomes, but clinician acceptance remains a critical barrier. We developed a novel decision support interface that provides interpretable treatment…

Human-Computer Interaction · Computer Science 2023-02-02 Venkatesh Sivaraman , Leigh A. Bukowski , Joel Levin , Jeremy M. Kahn , Adam Perer

A Clinical Decision Support System (CDSS) is designed to enhance clinician decision-making by combining system-generated recommendations with medical expertise. Given the high costs, intensive labor, and time-sensitive nature of medical…

Computation and Language · Computer Science 2024-10-22 Pei-Hung Chung , Shuhan He , Norawit Kijpaisalratana , Abdel-badih el Ariss , Byung-Jun Yoon

Deep learning, an area of machine learning, is set to revolutionize patient care. But it is not yet part of standard of care, especially when it comes to individual patient care. In fact, it is unclear to what extent data-driven techniques…

Machine Learning · Computer Science 2019-06-07 Gal Levy-Fix , Gilad J. Kuperman , Noémie Elhadad

Artificial Intelligence (AI) is a broad field that is upturning mental health care in many ways, from addressing anxiety, depression, and stress to increasing access, personalization of treatment, and real-time monitoring that enhances…

Computers and Society · Computer Science 2025-01-22 Hari Mohan Pandey

Current clinical decision support systems (CDSSs) typically base their predictions on correlation, not causation. In recent years, causal machine learning (ML) has emerged as a promising way to improve decision-making with CDSSs by offering…

Human-Computer Interaction · Computer Science 2026-04-17 Domenique Zipperling , Lukas Schmidt , Benedikt Hahn , Niklas Kühl , Steven Kimbrough

AI-based decision support tools (ADS) are increasingly used to augment human decision-making in high-stakes, social contexts. As public sector agencies begin to adopt ADS, it is critical that we understand workers' experiences with these…

The COVID-19 pandemic has forced many people to limit their social activities, which has resulted in a rise in mental illnesses, particularly depression. To diagnose these illnesses with accuracy and speed, and prevent severe outcomes such…

Machine Learning · Computer Science 2023-11-14 Hossein Simchi , Samira Tajik
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