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Training recurrent neuronal networks consisting of excitatory (E) and inhibitory (I) units with additive noise for working memory computation slows and diversifies inhibitory timescales, leading to improved task performance that is…

Neurons and Cognition · Quantitative Biology 2025-12-19 Thiparat Chotibut , Oleg Evnin , Weerawit Horinouchi

In this work we consider the Allen--Cahn equation, a prototypical model problem in nonlinear dynamics that exhibits bifurcations corresponding to variations of a deterministic bifurcation parameter. Going beyond the state-of-the-art, we…

Numerical Analysis · Mathematics 2024-08-14 Christian Kuehn , Chiara Piazzola , Elisabeth Ullmann

Deep neural networks are known to suffer from exploding or vanishing gradients as depth increases, a phenomenon closely tied to the spectral behavior of the input-output Jacobian. Prior work has identified critical initialization schemes…

Machine Learning · Computer Science 2025-11-25 Benjamin Dadoun , Soufiane Hayou , Hanan Salam , Mohamed El Amine Seddik , Pierre Youssef

Motivated by investigating multistationarity in biochemical systems, we address saddle-node bifurcations for chemical reaction networks endowed with general kinetics. At positive equilibria, we identify structural network conditions that…

Dynamical Systems · Mathematics 2023-07-24 Nicola Vassena

Deep neural networks are notorious for defying theoretical treatment. However, when the number of parameters in each layer tends to infinity, the network function is a Gaussian process (GP) and quantitatively predictive description is…

Machine Learning · Computer Science 2023-10-09 Darshil Doshi , Tianyu He , Andrey Gromov

An efficient structural identifiability analysis algorithm is developed in this study for a broad range of network structures. The proposed method adopts the Wright's path coefficient method to generate identifiability equations in forms of…

Molecular Networks · Quantitative Biology 2017-08-25 Yulin Wang , Na Lu , Hongyu Miao

The presence of slow-fast Hopf (or singular Hopf) points in slow-fast systems in the plane is often deduced from the shape of a vector field brought into normal form. It can however be quite cumbersome to put a system in normal form. In the…

Dynamical Systems · Mathematics 2021-11-10 Peter De Maesschalck , Thai Son Doan , Jeroen Wynen

Chemical reaction network theory is a powerful framework to describe and analyze chemical systems. While much about the concentration profile in an equilibrium state can be determined in terms of the graph structure, the overall reaction's…

Molecular Networks · Quantitative Biology 2024-02-29 Tomoharu Suda

Chemical reaction network theory is a field of applied mathematics concerned with modeling chemical systems, and can be used in other contexts such as in systems biology to study cellular signaling pathways or epidemiology to study the…

Algebraic Geometry · Mathematics 2024-06-17 Maize Curiel , Elise Farr , Galileo Fries , Luis David García Puente , Julian Hutchins , Vuong Nguyen Hoang

To make predictions or design control, information on local sensitivity of initial conditions and state-space contraction is both central, and often instrumental. However, it is not always simple to reliably determine instability fields or…

We study the Jacobian conjecture for Keller maps $f:X_0:=\mathbf{A}^n\rightarrow Y_0:=\mathbf{A}^n$ in characteristic $0$ and attempt to prove it. We are quite aware of the fact that many people have tried to prove the Jacobian conjecture…

Algebraic Geometry · Mathematics 2016-08-19 Louis Hugo Brewis

Feedback circuits in biochemical networks which underly cellular signaling pathways are important elements in creating complex behavior. A specific aspect thereof is how stability of equilibrium points depends on model parameters. For…

Molecular Networks · Quantitative Biology 2007-11-20 Steffen Waldherr , Frank Allgower

Symbolic models have recently spurred the interest of the research community because they offer a correct-by-design approach to the control of embedded and cyber-physical systems. In this paper we address construction of symbolic models for…

Optimization and Control · Mathematics 2014-08-15 Giordano Pola , Pierdomenico Pepe , Maria Domenica Di Benedetto

We present a symbolic algorithmic approach that allows to compute invariant manifolds and corresponding reduced systems for differential equations modeling biological networks which comprise chemical reaction networks for cellular…

Molecular Networks · Quantitative Biology 2021-03-03 Niclas Kruff , Christoph Lüders , Ovidiu Radulescu , Thomas Sturm , Sebastian Walcher

Learning expressive probabilistic models correctly describing the data is a ubiquitous problem in machine learning. A popular approach for solving it is mapping the observations into a representation space with a simple joint distribution,…

Machine Learning · Statistics 2020-10-28 Luigi Gresele , Giancarlo Fissore , Adrián Javaloy , Bernhard Schölkopf , Aapo Hyvärinen

Networks are abundant in biological systems. Small sized over-represented network motifs have been discovered, and it has been suggested that these constitute functional building blocks. We ask whether larger dynamical network motifs exist…

Neural and Evolutionary Computing · Computer Science 2018-09-25 C. H. Huck Yang , Rise Ooi , Tom Hiscock , Victor Eguiluz , Jesper Tegnér

In this work, we conduct a rigorous analysis on the dynamics of a predator-prey model with cooperative predation. From the root classification of an algebraic equation, we derive existence criteria of the positive equilibria. By Jacobian…

Classical Analysis and ODEs · Mathematics 2021-08-24 Srijana Ghimire , Xiang-Sheng Wang

We consider linear elimination of variables in steady state equations of a chemical reaction network. Particular subsets of variables corresponding to sets of so-called reactant-noninteracting species, are introduced. The steady state…

Molecular Networks · Quantitative Biology 2018-07-03 Meritxell Sáez , Carsten Wiuf , Elisenda Feliu

We examine the geometry of neural network training using the Jacobian of trained network parameters with respect to their initial values. Our analysis reveals low-dimensional structure in the training process which is dependent on the input…

Machine Learning · Computer Science 2024-12-12 Nora Belrose , Adam Scherlis

Bifurcations leading to complex dynamical behaviour of non-linear systems are often encountered when the characteristics of feedback circuits in the system are varied. In systems with many unknown or varying parameters, it is an…

Molecular Networks · Quantitative Biology 2010-09-23 Steffen Waldherr , Frank Allgöwer