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Electronic Health Records (EHRs) are rich sources of patient-level data, offering valuable resources for medical data analysis. However, privacy concerns often restrict access to EHRs, hindering downstream analysis. Current EHR…

Machine Learning · Computer Science 2024-12-03 Muhang Tian , Bernie Chen , Allan Guo , Shiyi Jiang , Anru R. Zhang

Electronic health records (EHRs) are a pivotal data source that enables numerous applications in computational medicine, e.g., disease progression prediction, clinical trial design, and health economics and outcomes research. Despite wide…

Machine Learning · Computer Science 2024-06-18 Jun Han , Zixiang Chen , Yongqian Li , Yiwen Kou , Eran Halperin , Robert E. Tillman , Quanquan Gu

Electronic health records (EHR) contain a wealth of biomedical information, serving as valuable resources for the development of precision medicine systems. However, privacy concerns have resulted in limited access to high-quality and…

Machine Learning · Computer Science 2024-03-26 Hongyi Yuan , Songchi Zhou , Sheng Yu

This paper presents a novel approach to simulating electronic health records (EHRs) using diffusion probabilistic models (DPMs). Specifically, we demonstrate the effectiveness of DPMs in synthesising longitudinal EHRs that capture…

Machine Learning · Computer Science 2023-03-23 Nicholas I-Hsien Kuo , Louisa Jorm , Sebastiano Barbieri

Due to patient privacy protection concerns, machine learning research in healthcare has been undeniably slower and limited than in other application domains. High-quality, realistic, synthetic electronic health records (EHRs) can be…

Machine Learning · Computer Science 2023-02-10 Huan He , Shifan Zhao , Yuanzhe Xi , Joyce C Ho

Synthesizing electronic health records (EHR) data has become a preferred strategy to address data scarcity, improve data quality, and model fairness in healthcare. However, existing approaches for EHR data generation predominantly rely on…

Machine Learning · Computer Science 2024-06-21 Yuan Zhong , Xiaochen Wang , Jiaqi Wang , Xiaokun Zhang , Yaqing Wang , Mengdi Huai , Cao Xiao , Fenglong Ma

Electronic health records (EHRs) are invaluable for clinical research, yet privacy concerns severely restrict data sharing. Synthetic data generation offers a promising solution, but EHRs present unique challenges: they contain both…

Machine Learning · Computer Science 2026-03-26 Shaonan Liu , Yuichiro Iwashita , Soichiro Nakako , Masakazu Iwamura , Koichi Kise

Sharing electronic health records (EHRs) on a large scale may lead to privacy intrusions. Recent research has shown that risks may be mitigated by simulating EHRs through generative adversarial network (GAN) frameworks. Yet the methods…

Machine Learning · Computer Science 2020-03-25 Chao Yan , Ziqi Zhang , Steve Nyemba , Bradley A. Malin

Machine Learning (ML) is accelerating progress across fields and industries, but relies on accessible and high-quality training data. Some of the most important datasets are found in biomedical and financial domains in the form of…

Machine Learning · Computer Science 2023-08-30 Gianluca Truda

The recent availability of electronic health records (EHRs) have provided enormous opportunities to develop artificial intelligence (AI) algorithms. However, patient privacy has become a major concern that limits data sharing across…

Machine Learning · Computer Science 2023-02-01 Jin Li , Benjamin J. Cairns , Jingsong Li , Tingting Zhu

Realistic synthetic tabular data generation encounters significant challenges in preserving privacy, especially when dealing with sensitive information in domains like finance and healthcare. In this paper, we introduce \textit{Federated…

Machine Learning · Computer Science 2024-01-15 Timur Sattarov , Marco Schreyer , Damian Borth

Synthetic health data have the potential to mitigate privacy concerns when sharing data to support biomedical research and the development of innovative healthcare applications. Modern approaches for data generation based on machine…

Machine Learning · Computer Science 2023-01-11 Chao Yan , Yao Yan , Zhiyu Wan , Ziqi Zhang , Larsson Omberg , Justin Guinney , Sean D. Mooney , Bradley A. Malin

This study investigates the privacy risks associated with diffusion-based synthetic tabular data generation methods, focusing on their susceptibility to Membership Inference Attacks (MIAs). We examine two recent models, TabDDPM and TabSyn,…

Cryptography and Security · Computer Science 2025-10-21 Peini Cheng , Amir Bahmani

Electronic Health Records (EHRs) are a valuable asset to facilitate clinical research and point of care applications; however, many challenges such as data privacy concerns impede its optimal utilization. Deep generative models,…

Machine Learning · Computer Science 2024-01-12 Ghadeer Ghosheh , Jin Li , Tingting Zhu

Deep learning in cardiac MRI (CMR) is fundamentally constrained by both data scarcity and privacy regulations. This study systematically benchmarks three generative architectures: Denoising Diffusion Probabilistic Models (DDPM), Latent…

Computer Vision and Pattern Recognition · Computer Science 2026-03-05 Madhura Edirisooriya , Dasuni Kawya , Ishan Kumarasinghe , Isuri Devindi , Mary M. Maleckar , Roshan Ragel , Isuru Nawinne , Vajira Thambawita

Synthetic data from generative models emerges as the privacy-preserving data sharing solution. Such a synthetic data set shall resemble the original data without revealing identifiable private information. Till date, the prior focus on…

Machine Learning · Computer Science 2025-07-23 Chaoyi Zhu , Jiayi Tang , Juan F. Pérez , Marten van Dijk , Lydia Y. Chen

Access to electronic health record (EHR) data has motivated computational advances in medical research. However, various concerns, particularly over privacy, can limit access to and collaborative use of EHR data. Sharing synthetic EHR data…

Machine Learning · Computer Science 2018-01-15 Edward Choi , Siddharth Biswal , Bradley Malin , Jon Duke , Walter F. Stewart , Jimeng Sun

Denoising diffusion probabilistic models are currently becoming the leading paradigm of generative modeling for many important data modalities. Being the most prevalent in the computer vision community, diffusion models have also recently…

Machine Learning · Computer Science 2024-10-08 Akim Kotelnikov , Dmitry Baranchuk , Ivan Rubachev , Artem Babenko

Tabular data is one of the most prevalent and important data formats in real-world applications such as healthcare, finance, and education. However, its effective use in machine learning is often constrained by data scarcity, privacy…

Machine Learning · Computer Science 2025-07-18 Ruxue Shi , Yili Wang , Mengnan Du , Xu Shen , Yi Chang , Xin Wang

Generative models have been found effective for data synthesis due to their ability to capture complex underlying data distributions. The quality of generated data from these models is commonly evaluated by visual inspection for image…

Machine Learning · Computer Science 2022-10-18 Emily Muller , Xu Zheng , Jer Hayes
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