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Presented with sensory challenges, living cells employ extensive noisy, fluctuating signalling and communication among themselves to compute a physiologically proper response which often results in symmetry breaking. We propose, based on…

Biological Physics · Physics 2022-06-17 Dean Korošak , Andraž Stožer , Marjan Slak Rupnik

We study the problem of controlling oscillations in closed loop by combining positive and negative feedback in a mixed configuration. We develop a complete design procedure to set the relative strength of the two feedback loops to achieve…

Systems and Control · Electrical Eng. & Systems 2021-09-08 W. Che , F. Forni

The exponential growth of the power of modern digital computers is based upon the miniaturisation of vast nanoscale arrays of electronic switches, but this will be eventually constrained by fabrication limits and power dissipation. Chemical…

Emerging Technologies · Computer Science 2022-04-29 Abhishek Sharma , Marcus Tze-Kiat Ng , Juan Manuel Parrilla Gutierrez , Yibin Jiang , Leroy Cronin

Biological cells encode information about their environment through biochemical signaling networks that control their internal state and response. This information is often encoded in the dynamical patterns of the signaling molecules,…

Molecular Networks · Quantitative Biology 2023-04-24 Lauritz Hahn , Aleksandra M. Walczak , Thierry Mora

Quantum optimal control is a technique for controlling the evolution of a quantum system and has been applied to a wide range of problems in quantum physics. We study a binary quantum control optimization problem, where control decisions…

Quantum Physics · Physics 2024-10-15 Xinyu Fei , Lucas T. Brady , Jeffrey Larson , Sven Leyffer , Siqian Shen

Clock synchronization is a widely discussed topic in the engineering literature. Ensuring that individual clocks are closely aligned is important in network systems, since the correct timing of various events in a network is usually…

Systems and Control · Computer Science 2017-04-25 Timothy Anglea , Yongqiang Wang

On a chassis of gear model, we have offered a quantitative description for our method to synthesize a chemical clock signal with various duty cycles in Part I. As Part II of the study, this paper devotes itself in proposing a design…

Molecular Networks · Quantitative Biology 2018-02-23 Chuan Zhang , Lulu Ge , Xiaohu You

Building oscillator based computing systems with emerging nano-device technologies has become a promising solution for unconventional computing tasks like computer vision and pattern recognition. However, simulation and analysis of these…

Emerging Technologies · Computer Science 2016-11-15 Yan Fang , Victor V. Yashin , Donald M. Chiarulli , Steven P. Levitan

In this work we address the question of how oscillations are arrested in the mouse somitogenesis clock when the determination front reaches presomitic cells. Based upon available experimental evidence we hypothesize that the mechanism…

Cell Behavior · Quantitative Biology 2015-03-13 Eder Zavala-López , Moisés Santillán

Biological oscillators coordinate individual cellular components so that they function coherently and collectively. They are typically composed of multiple feedback loops, and period mismatch is unavoidable in biological implementations. We…

Biological Physics · Physics 2013-05-06 Yoshihiko Hasegawa , Masanori Arita

Synthetic biology sets out to implement new functions in cells, and to develop a deeper understanding of biological design principles. In 2000, Elowitz and Leibler showed that by rational design of the reaction network, and using existing…

Biological Physics · Physics 2017-05-17 Joris Paijmans , David K Lubensky , Pieter Rein ten Wolde

Biochemical clocks are essential for virtually all living systems. A biochemical clock that is isolated from an external periodic signal and subjected to fluctuations can oscillate coherently only for a finite number of oscillations.…

Statistical Mechanics · Physics 2022-10-03 Lukas Oberreiter , Udo Seifert , Andre C. Barato

Limit cycles are self-sustained, closed trajectories in phase space representing (un)-stable, periodic behavior in nonlinear dynamical systems. They underpin diverse natural phenomena, from neuronal firing patterns to engineering…

Adaptation and Self-Organizing Systems · Physics 2025-08-15 Sandip Saha , Suvam Pal , Dibakar Ghosh

A fundamental problem in experiments with open quantum systems is to ensure steady-state convergence within a given operational time window. Here, we devise a general state preparation recipe to control relaxation timescales and achieve…

Quantum Physics · Physics 2026-03-02 Nicolò Beato , Gianluca Teza

In this paper we review recent work on novel computing paradigms using coupled oscillatory dynamical systems. We explore systems of relaxation oscillators based on linear state transitioning devices, which switch between two discrete states…

Emerging Technologies · Computer Science 2016-08-22 Abhinav Parihar , Nikhil Shukla , Matthew Jerry , Suman Datta , Arijit Raychowdhury

We describe the use of quasiperiodic oscillators for computation and control of robots. We also describe their relationship to central pattern generators in simple organisms and develop a group theory for describing the dynamics of these…

Robotics · Computer Science 2007-05-23 E. A. Rietman , R. W. Hillis

Molecular and lattice vibrations are able to couple to the spin of electrons and lead to their relaxation and decoherence. Ab initio simulations have played a fundamental role in shaping our understanding of this process but further…

Materials Science · Physics 2024-10-14 Valerio Briganti , Alessandro Lunghi

Optomechanical oscillators stand out as high-performance and versatile candidates for serving as reference clocks in sequential photonic integrated circuits. Indeed, they have the unique capability of simultaneously generating mechanical…

Cluster synchronization is a fundamental phenomenon in systems of coupled oscillators. Here, we investigate clustering patterns that emerge in a unidirectional ring of four delay-coupled electrochemical oscillators. A voltage parameter in…

Dynamical Systems · Mathematics 2023-06-28 Andrew Keane , Alannah Neff , Karen Blaha , Andreas Amann , Philipp Hövel

Being able to measure time, whether directly or indirectly, is a significant advantage for an organism. It allows for the timely reaction to regular or predicted events, reducing the pressure for fast processing of sensory input. Thus,…

Other Quantitative Biology · Quantitative Biology 2019-06-19 Andrei D. Robu , Christoph Salge , Chrystopher L. Nehaniv , Daniel Polani