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The search for complex organic molecules in the interstellar medium (ISM) has revealed species of ever greater complexity. This search relies on the progress made in the laboratory to characterize their rotational spectra. Our understanding…

Astrophysics of Galaxies · Physics 2020-10-14 Arnaud Belloche

Spectroscopic techniques are essential tools for determining the structure of molecules. Different spectroscopic techniques, such as Nuclear magnetic resonance (NMR), Infrared spectroscopy, and Mass Spectrometry, provide insight into the…

Chemical Physics · Physics 2024-10-30 Marvin Alberts , Oliver Schilter , Federico Zipoli , Nina Hartrampf , Teodoro Laino

Molecular assembly offers a promising path to detect life beyond Earth, while minimizing assumptions based on terrestrial life. As mass spectrometers will be central to upcoming Solar System missions, predicting molecular assembly from…

Machine Learning · Computer Science 2025-07-28 Lindsay A. Rutter , Abhishek Sharma , Ian Seet , David Obeh Alobo , An Goto , Leroy Cronin

A proof-of-concept framework for identifying molecules of unknown elemental composition and structure using experimental rotational data and probabilistic deep learning is presented. Using a minimal set of input data determined…

Chemical Physics · Physics 2020-07-01 Michael C. McCarthy , Kin Long Kelvin Lee

The calculation of the molecular column density from molecular spectral (rotational or ro-vibrational) transition measurements is one of the most basic quantities derived from molecular spectroscopy. Starting from first principles where we…

Instrumentation and Methods for Astrophysics · Physics 2017-04-10 Jeffrey G. Mangum , Yancy L. Shirley

The similarity of local atomic environments is an important concept in many machine-learning techniques which find applications in computational chemistry and material science. Here, we present and discuss a connection between the…

Chemical Physics · Physics 2026-03-03 Alexander Croy

The determination of chemical mixture components is vital to a multitude of scientific fields. Oftentimes spectroscopic methods are employed to decipher the composition of these mixtures. However, the sheer density of spectral features…

Astrophysics of Galaxies · Physics 2024-08-29 Zachary T. P. Fried , Brett A. McGuire

Metabolomics complements investigation of the genome, transcriptome, and proteome of an organism. Today, the vast majority of metabolites remain unknown, in particular for non-model organisms. Mass spectrometry is one of the predominant…

Quantitative Methods · Quantitative Biology 2013-07-31 Kai Dührkop , Marcus Ludwig , Marvin Meusel , Sebastian Böcker

Quantifying the evolution and complexity of materials is of importance in many areas of science and engineering, where a central open challenge is developing experimental complexity measurements to distinguish random structures from evolved…

Materials Science · Physics 2025-02-26 Keith Y Patarroyo , Abhishek Sharma , Ian Seet , Ignas Packmore , Sara I. Walker , Leroy Cronin

Self-assembly in natural and synthetic molecular systems can create complex aggregates or materials whose properties and functionality rises from their internal structure and molecular arrangement. The key microscopic features that control…

Soft Condensed Matter · Physics 2021-09-03 Alberto Scacchi , Maria Sammalkorpi , Tapio Ala-Nissila

Interpreting spectroscopy data is a critical bottleneck in automating chemical research and industrial characterization. Particularly within infrared (IR) spectroscopy, identifying compounds in complex, liquid-phase chemical mixtures…

Materials Science · Physics 2026-02-26 Yannah J. U. Melle , Thanh Nguyen , Jeffrey Lopez , Daniel Schwalbe-Koda

The coupling of an electron monochromator (EM) to a mass spectrometer (MS) has created a new analytical technique, EM-MS, for the investigation of electrophilic compounds. This method provides a powerful tool for molecular identification of…

We present a quantitative measure of physical complexity, based on the amount of information required to build a given physical structure through self-assembly. Our procedure can be adapted to any given geometry, and thus to any given type…

Statistical Mechanics · Physics 2010-09-02 S. E. Ahnert , I. G. Johnston , T. M. A. Fink , J. P. K. Doye , A. A. Louis

Accurately predicting infrared (IR) spectra in computational chemistry using ab initio methods remains a challenge. Current approaches often rely on an empirical approach or on tedious anharmonic calculations, mainly adapted to semi-rigid…

Chemical Physics · Physics 2024-09-05 Saleh Abdul Al , Abdul-Rahman Allouche

Water is the most important solvent in nature. It is a crucial issue to study interactions among water molecules. Nuclear magnetic resonance (NMR) spectroscopy is one of the most powerful tools to detect magnetic interactions for the…

Quantum Physics · Physics 2018-05-30 Xi Kong , Fazhan Shi , Zhiping Yang , Pengfei Wang , Nicole Raatz , Jan Meijer , Jiangfeng Du

The discovery and identification of molecules in biological and environmental samples is crucial for advancing biomedical and chemical sciences. Tandem mass spectrometry (MS/MS) is the leading technique for high-throughput elucidation of…

ALMA will be able to detect a broad spectrum of molecular lines in galaxies. Current aperture synthesis observations indicate that the molecular line emission from galaxies is remarkably variable, even on kpc scales. Imaging spectroscopy at…

Astrophysics · Physics 2009-06-23 Jean L. Turner , David S. Meier

In physics, it is sometimes desirable to compute the so-called \emph{Density Of States} (DOS), also known as the \emph{spectral density}, of a real symmetric matrix $A$. The spectral density can be viewed as a probability density…

Numerical Analysis · Mathematics 2014-10-07 Lin Lin , Yousef Saad , Chao Yang

Introduction: molecular geometry, the three-dimensional arrangement of atoms within a molecule, is fundamental to understanding chemical reactivity, physical properties, and biological activity. The prevailing models used to describe…

General Physics · Physics 2026-05-12 Sebastian Ali Sacasa-Cespedes

Astrochemistry aims at studying chemical processes in astronomical environments. This discipline -- located at the crossroad between astrophysics and chemistry -- is rapidly evolving and explores the issue of the formation of molecules of…

Astrophysics of Galaxies · Physics 2013-05-28 M. De Becker
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