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Summary: Raw nanopore signals can be analyzed while they are being generated, a process known as real-time analysis. Real-time analysis of raw signals is essential to utilize the unique features that nanopore sequencing provides, enabling…

Genomics · Quantitative Biology 2024-08-14 Can Firtina , Melina Soysal , Joël Lindegger , Onur Mutlu

Research on the localization of the genetic basis associated with diseases or traits has been widely conducted in the last a few decades. Scan methods have been developed for region-based analysis in whole-genome association studies,…

Methodology · Statistics 2024-10-31 Wei Zhang , Fan Wang , Fang Yao

Early detection of cancer is essential for timely diagnosis and improved patient outcomes. Among emerging technologies, intra-body nanoscale communication offers an innovative solution to identify molecular cues within the human…

Emerging Technologies · Computer Science 2026-03-12 Abdollah Rezagholi , Sergi Abadal , Filip Lemic , Eduard Alarcon , Ethungshan Shitiri

Optical sensing is one of the key-enablers of modern diagnostics. Especially label-free imaging modalities hold great promise as they eliminate labeling procedures prior to analysis. However, scattering signals of nanometric particles scale…

Optics · Physics 2021-02-03 Unai Ortiz-Orruño , Ala Jo , Hakho Lee , Niek F. van Hulst , Matz Liebel

Surface Plasmon Resonance sensors are a well-established class of sensors which includes a very large variety of materials and detection schemes. However, the development of portable devices is still challenging as due to the intrinsic…

Mixture - modeling of mass spectra is an approach with many potential applications including peak detection and quantification, smoothing, de-noising, feature extraction and spectral signal compression. However, existing algorithms do not…

Computation · Statistics 2015-08-04 Andrzej Polanski , Michal Marczyk , Monika Pietrowska , Piotr Widlak , Joanna Polanska

Proteins are sequences of amino acids that serve as the basic building blocks of living organisms. Despite rapidly growing databases documenting structural and functional information for various protein sequences, our understanding of…

Biomolecules · Quantitative Biology 2025-01-06 Weihang Dai

To prepare for identifying the composition of nanowire-fiber mixtures in Scanning Electron Microscope (SEM) images, we optimize the performance of image classification between nanowires, fibers and tips due to their geometric similarities.…

Materials Science · Physics 2021-03-24 C. H. Wong , S. M. Ng , C. W. Leung , A. F. Zatsepin

Superconducting nanowire single-photon detectors (SNSPDs) have been widely used to study the discrete nature of quantum states of light in the form of photon-counting experiments. We show that SNSPDs can also be used to study continuous…

Quantum Physics · Physics 2024-11-12 Maximilian Protte , Timon Schapeler , Jan Sperling , Tim J. Bartley

The knowledge regarding the function of proteins is necessary as it gives a clear picture of biological processes. Nevertheless, there are many protein sequences found and added to the databases but lacks functional annotation. The…

Quantitative Methods · Quantitative Biology 2018-09-13 Anu Vazhayil , Vinayakumar R , Soman KP

Fingerprints are widely recognized as one of the most unique and reliable characteristics of human identity. Most modern fingerprint authentication systems rely on contact-based fingerprints, which require the use of fingerprint scanners or…

Computer Vision and Pattern Recognition · Computer Science 2023-11-28 M. G. Sarwar Murshed , Syed Konain Abbas , Sandip Purnapatra , Daqing Hou , Faraz Hussain

The characterization of individual nanoparticles in a liquid constitutes a critical challenge for environmental, material, and biological sciences. To detect nanoparticles, electronic approaches are especially desirable owing to their…

Conventional colorimetric sensing methods typically rely on signal intensity at a single wavelength, often selected heuristically based on peak visual modulation. This approach overlooks the structured information embedded in full-spectrum…

Medical Physics · Physics 2026-04-16 Majid Aalizadeh , Chinmay Raut , Ali Tabartehfarahani , Xudong Fan

Temporary changes in electrical resistance of a nanopore sensor caused by translocating target analytes are recorded as a sequence of pulses on current traces. Prevalent algorithms for feature extraction in pulse-like signals lack…

Signal Processing · Electrical Eng. & Systems 2021-05-11 Dario Dematties , Chenyu Wen , Mauricio David Pérez , Dian Zhou , Shi-Li Zhang

Current optical detection schemes for single molecules require light absorption, either to produce fluorescence or direct absorption signals. This severely limits the range of molecules that can be detected, because most molecules are…

Chemical Physics · Physics 2012-07-06 Peter Zijlstra , Pedro M. R. Paulo , Michel Orrit

Unravelling protein distributions within individual cells is key to understanding their function and state and indispensable to developing new treatments. Here we present the Hybrid subCellular Protein Localiser (HCPL), which learns from…

Computer Vision and Pattern Recognition · Computer Science 2022-09-20 Syed Sameed Husain , Eng-Jon Ong , Dmitry Minskiy , Mikel Bober-Irizar , Amaia Irizar , Miroslaw Bober

Recently, deep convolutional neural networks have shown good results for image recognition. In this paper, we use convolutional neural networks with a finder module, which discovers the important region for recognition and extracts that…

Computer Vision and Pattern Recognition · Computer Science 2018-12-27 Yusei Miura , Tetsuya Sakurai , Claus Aranha , Toshiya Senda , Ryuichi Kato , Yusuke Yamada

Proteins are fundamental biological entities mediating key roles in cellular function and disease. This paper introduces a multi-scale graph construction of a protein -- HoloProt -- connecting surface to structure and sequence. The surface…

Machine Learning · Computer Science 2022-04-06 Vignesh Ram Somnath , Charlotte Bunne , Andreas Krause

We are now witnessing significant progress of deep learning methods in a variety of tasks (or datasets) of proteins. However, there is a lack of a standard benchmark to evaluate the performance of different methods, which hinders the…

Machine Learning · Computer Science 2022-09-20 Minghao Xu , Zuobai Zhang , Jiarui Lu , Zhaocheng Zhu , Yangtian Zhang , Chang Ma , Runcheng Liu , Jian Tang

Increasing attention is being paid to millimeter-wave (mmWave), 30 GHz to 300 GHz, and terahertz (THz), 300 GHz to 10 THz, sensing applications including security sensing, industrial packaging, medical imaging, and non-destructive testing.…

Signal Processing · Electrical Eng. & Systems 2023-06-28 Josiah Smith