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Nuclei segmentation is a fundamental task that is critical for various computational pathology applications including nuclei morphology analysis, cell type classification, and cancer grading. Conventional vision-based methods for nuclei…

Computer Vision and Pattern Recognition · Computer Science 2018-10-23 Faisal Mahmood , Daniel Borders , Richard Chen , Gregory N. McKay , Kevan J. Salimian , Alexander Baras , Nicholas J. Durr

Segmentation of nuclei regions from histological images is an important task for automated computer-aided analysis of histological images, particularly in the presence of impermissible color variation in the color appearance of stained…

Image and Video Processing · Electrical Eng. & Systems 2025-06-10 Suman Mahapatra , Pradipta Maji

Self-supervised pretraining attempts to enhance model performance by obtaining effective features from unlabeled data, and has demonstrated its effectiveness in the field of histopathology images. Despite its success, few works concentrate…

Computer Vision and Pattern Recognition · Computer Science 2023-09-22 Zhiyun Song , Penghui Du , Junpeng Yan , Kailu Li , Jianzhong Shou , Maode Lai , Yubo Fan , Yan Xu

Histopathological images contain rich phenotypic information that can be used to monitor underlying mechanisms contributing to diseases progression and patient survival outcomes. Recently, deep learning has become the mainstream…

Image and Video Processing · Electrical Eng. & Systems 2020-10-28 Chetan L. Srinidhi , Ozan Ciga , Anne L. Martel

Nucleus segmentation is a challenging task due to the crowded distribution and blurry boundaries of nuclei. Recent approaches represent nuclei by means of polygons to differentiate between touching and overlapping nuclei and have…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Shengcong Chen , Changxing Ding , Minfeng Liu , Jun Cheng , Dacheng Tao

Nuclei detection is an important task in the histology domain as it is a main step toward further analysis such as cell counting, cell segmentation, study of cell connections, etc. This is a challenging task due to the complex texture of…

Computer Vision and Pattern Recognition · Computer Science 2018-08-28 Navid Alemi Koohababni , Mostafa Jahanifar , Ali Gooya , Nasir Rajpoot

Histopathological images are widely used for the analysis of diseased (tumor) tissues and patient treatment selection. While the majority of microscopy image processing was previously done manually by pathologists, recent advances in…

Image and Video Processing · Electrical Eng. & Systems 2024-07-12 Andrey Ignatov , Josephine Yates , Valentina Boeva

AI-assisted nuclei segmentation in histopathological images is a crucial task in the diagnosis and treatment of cancer diseases. It decreases the time required to manually screen microscopic tissue images and can resolve the conflict…

Image and Video Processing · Electrical Eng. & Systems 2023-11-21 Hesham Ali , Idriss Tondji , Mennatullah Siam

Histopathology image synthesis aims to address the data shortage issue in training deep learning approaches for accurate cancer detection. However, existing methods struggle to produce realistic images that have accurate nuclei boundaries…

Image and Video Processing · Electrical Eng. & Systems 2023-01-25 Sujata Butte , Haotian Wang , Aleksandar Vakanski , Min Xian

Despite the effectiveness of Convolutional Neural Networks (CNNs) for image classification, our understanding of the relationship between shape of convolution kernels and learned representations is limited. In this work, we explore and…

Computer Vision and Pattern Recognition · Computer Science 2016-11-30 Zhun Sun , Mete Ozay , Takayuki Okatani

Melanoma is the most lethal form of skin cancer, with an increasing incidence rate worldwide. Analyzing histological images of melanoma by localizing and classifying tissues and cell nuclei is considered the gold standard method for…

Computer Vision and Pattern Recognition · Computer Science 2025-09-03 Nima Torbati , Anastasia Meshcheryakova , Ramona Woitek , Sepideh Hatamikia , Diana Mechtcheriakova , Amirreza Mahbod

Cell nuclei detection is a challenging research topic because of limitations in cellular image quality and diversity of nuclear morphology, i.e. varying nuclei shapes, sizes, and overlaps between multiple cell nuclei. This has been a topic…

Image and Video Processing · Electrical Eng. & Systems 2019-01-23 Mohammad Tofighi , Tiantong Guo , Jairam K. P. Vanamala , Vishal Monga

We present a novel neural network architecture, US-Net, for robust nuclei instance segmentation in histopathology images. The proposed framework integrates the nuclei detection and segmentation networks by sharing their outputs through the…

Computer Vision and Pattern Recognition · Computer Science 2019-02-04 Zhaoyang Xu , Faranak Sobhani , Carlos Fernandez Moro , Qianni Zhang

Image segmentation is a fundamental and challenging problem in computer vision with applications spanning multiple areas, such as medical imaging, remote sensing, and autonomous vehicles. Recently, convolutional neural networks (CNNs) have…

Computer Vision and Pattern Recognition · Computer Science 2020-06-24 Ali Hatamizadeh

Histopathologic diagnosis relies on simultaneous integration of information from a broad range of scales, ranging from nuclear aberrations ($\approx \mathcal{O}(0.1{\mu m})$) through cellular structures ($\approx \mathcal{O}(10{\mu m})$) to…

Image and Video Processing · Electrical Eng. & Systems 2021-02-23 Rüdiger Schmitz , Frederic Madesta , Maximilian Nielsen , Jenny Krause , René Werner , Thomas Rösch

In the computer vision literature, many effective histogram-based features have been developed. These engineered features include local binary patterns and edge histogram descriptors among others and they have been shown to be informative…

Computer Vision and Pattern Recognition · Computer Science 2025-07-29 Joshua Peeples , Salim Al Kharsa , Luke Saleh , Alina Zare

Nuclei instance segmentation on histopathology images is of great clinical value for disease analysis. Generally, fully-supervised algorithms for this task require pixel-wise manual annotations, which is especially time-consuming and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-06 Yang Zhou , Yongjian Wu , Zihua Wang , Bingzheng Wei , Maode Lai , Jianzhong Shou , Yubo Fan , Yan Xu

Volumetric image segmentation with convolutional neural networks (CNNs) encounters several challenges, which are specific to medical images. Among these challenges are large volumes of interest, high class imbalances, and difficulties in…

Computer Vision and Pattern Recognition · Computer Science 2019-11-12 Fabian Balsiger , Yannick Soom , Olivier Scheidegger , Mauricio Reyes

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational…

Image and Video Processing · Electrical Eng. & Systems 2022-02-25 Satoshi Kondo , Satoshi Kasai

Nuclei classification is a critical step in computer-aided diagnosis with histopathology images. In the past, various methods have employed graph neural networks (GNN) to analyze cell graphs that model inter-cell relationships by…

Computer Vision and Pattern Recognition · Computer Science 2024-02-21 Wei Lou , Guanbin Li , Xiang Wan , Haofeng Li