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The autoencoder is an unsupervised learning paradigm that aims to create a compact latent representation of data by minimizing the reconstruction loss. However, it tends to overlook the fact that most data (images) are embedded in a…

Machine Learning · Computer Science 2023-10-26 Alokendu Mazumder , Tirthajit Baruah , Bhartendu Kumar , Rishab Sharma , Vishwajeet Pattanaik , Punit Rathore

The manifold hypothesis states that high-dimensional data can be modeled as lying on or near a low-dimensional, nonlinear manifold. Variational Autoencoders (VAEs) approximate this manifold by learning mappings from low-dimensional latent…

Machine Learning · Statistics 2021-03-03 Marissa C. Connor , Gregory H. Canal , Christopher J. Rozell

In this paper, we demonstrate a computationally efficient new approach based on deep learning (DL) techniques for analysis, design, and optimization of electromagnetic (EM) nanostructures. We use the strong correlation among features of a…

Machine Learning · Computer Science 2020-02-13 Yashar Kiarashinejad , Sajjad Abdollahramezani , Ali Adibi

In the present work, a generative deep learning framework combining a Co-optimized Variational Autoencoder (Co-VAE) architecture with quantitative structure-property relationship (QSPR) techniques is developed to enable accelerated inverse…

Machine Learning · Computer Science 2025-10-15 Kiran K. Yalamanchi , Pinaki Pal , Balaji Mohan , Abdullah S. AlRamadan , Jihad A. Badra , Yuanjiang Pei

Autoencoders exhibit impressive abilities to embed the data manifold into a low-dimensional latent space, making them a staple of representation learning methods. However, without explicit supervision, which is often unavailable, the…

Machine Learning · Computer Science 2023-01-12 Felix Leeb , Stefan Bauer , Michel Besserve , Bernhard Schölkopf

The advent of neural-network-based deep learning techniques has led to the emergence of increasingly sophisticated numerical interatomic potentials, including graph neural networks and large language-motivated foundation models.…

Chemical Physics · Physics 2026-03-09 Susan R. Atlas

Sparse autoencoders have become a standard tool for uncovering interpretable latent representations in neural networks. Yet salient concepts often span manifolds that current linear methods cannot capture without post hoc analysis. This…

Machine Learning · Computer Science 2026-05-12 Thomas Dooms , Ward Gauderis , Geraint Wiggins , Jose Oramas

Designing complex physical systems, including photonic structures, is typically a tedious trial-and-error process that requires extensive simulations with iterative sweeps in multi-dimensional parameter space. To circumvent this…

Optics · Physics 2019-02-08 Zhaocheng Liu , Lakshmi Raju , Dayu Zhu , Wenshan Cai

Detectors in next-generation high-energy physics experiments face several daunting requirements, such as high data rates, damaging radiation exposure, and stringent constraints on power, space, and latency. To address these challenges,…

Data Analysis, Statistics and Probability · Physics 2025-08-18 Alexander Yue , Haoyi Jia , Julia Gonski

Novelty detection is the task of recognizing samples that do not belong to the distribution of the target class. During training, the novelty class is absent, preventing the use of traditional classification approaches. Deep autoencoders…

Computer Vision and Pattern Recognition · Computer Science 2021-11-11 John Taylor Jewell , Vahid Reza Khazaie , Yalda Mohsenzadeh

Structure-based drug discovery faces the dual challenge of accurately capturing 3D protein-ligand interactions while navigating ultra-large chemical spaces to identify synthetically accessible candidates. In this work, we present a unified…

Machine Learning · Computer Science 2026-04-22 Carles Navarro , Philipp Tholke , Gianni de Fabritiis

This article proposes a data-driven methodology to achieve a fast design support, in order to generate or develop novel designs covering multiple object categories. This methodology implements two state-of-the-art Variational Autoencoder…

Computer Vision and Pattern Recognition · Computer Science 2018-08-07 Zhangsihao Yang , Haoliang Jiang , Zou Lan

In this paper, we introduce a novel 3D mesh convolution-based autoencoder for geometry compression, able to deal with irregular mesh data without requiring neither preprocessing nor manifold/watertightness conditions. The proposed approach…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Germain Bregeon , Marius Preda , Radu Ispas , Titus Zaharia

Comprehensive and unambiguous identification of small molecules in complex samples will revolutionize our understanding of the role of metabolites in biological systems. Existing and emerging technologies have enabled measurement of…

Biomolecules · Quantitative Biology 2019-05-22 Sean M. Colby , Jamie R. Nuñez , Nathan O. Hodas , Courtney D. Corley , Ryan R. Renslow

In audio processing applications, the generation of expressive sounds based on high-level representations demonstrates a high demand. These representations can be used to manipulate the timbre and influence the synthesis of creative…

Sound · Computer Science 2023-01-19 Anastasia Natsiou , Luca Longo , Sean O'Leary

The discovery of new materials has been the essential force which brings a discontinuous improvement to industrial products' performance. However, the extra-vast combinatorial design space of material structures exceeds human experts'…

Enhanced modeling of microlensing variations in light curves of strongly lensed quasars improves measurements of cosmological time delays, the Hubble Constant, and quasar structure. Traditional methods for modeling extra-galactic…

Instrumentation and Methods for Astrophysics · Physics 2025-01-03 Somayeh Khakpash , Federica Bianco , Georgios Vernardos , Gregory Dobler , Charles Keeton

Deep learning (DL) has revolutionized many fields such as materials design and protein folding. Recent studies have demonstrated the advantages of DL in the inverse design of structural colors, by effectively learning the complex nonlinear…

Optics · Physics 2026-05-22 Sichao Shan , Han Ye , Zhengmei Yang , Junpeng Hou , Zhitong Li

This work presents a data-driven framework for fast forward and inverse analysis in topology optimization (TO) by combining Rank Reduction Autoencoders (RRAEs) with neural latent-space mappings. The methodology targets the efficient…

Model reduction of high-dimensional dynamical systems alleviates computational burdens faced in various tasks from design optimization to model predictive control. One popular model reduction approach is based on projecting the governing…

Dynamical Systems · Mathematics 2018-08-24 Francisco J. Gonzalez , Maciej Balajewicz