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Localization microscopy is an imaging technique in which the positions of individual nanoscale point emitters (e.g. fluorescent molecules) are determined at high precision from their images. This is the key ingredient in…

Image and Video Processing · Electrical Eng. & Systems 2020-10-01 Elias Nehme , Daniel Freedman , Racheli Gordon , Boris Ferdman , Lucien E. Weiss , Onit Alalouf , Reut Orange , Tomer Michaeli , Yoav Shechtman

A critical challenge in single-cell RNA sequencing (scRNA-seq) integration is resolving the tension between eliminating batch effects and maintaining biological fidelity. While recent evidence indicates that batch effects manifest…

Machine Learning · Computer Science 2026-05-19 Xichen Yan , Zelin Zang , Changxi Chi , Jingbo Zhou , Chang Yu , Jinlin Wu , Shenghui Cheng , Fuji Yang , Jiebo Luo , Zhen Lei , Stan Z. Li

Nanoscale secondary ion mass spectrometry (nanoSIMS) and fluorescence in situ hybridization (FISH) microscopy provide high-resolution, multimodal image representations of the identity and cell activity respectively of targeted microbial…

Computer Vision and Pattern Recognition · Computer Science 2022-04-07 Xiaojia He , Christof Meile , Suchendra M. Bhandarkar

Food images present unique challenges for few-shot learning models due to their visual complexity and variability. For instance, a pasta dish might appear with various garnishes on different plates and in diverse lighting conditions and…

Computer Vision and Pattern Recognition · Computer Science 2025-08-15 Javier Rodenas , Eduardo Aguilar , Petia Radeva

Neural representations have shown the potential to accelerate ray casting in a conventional ray-tracing-based rendering pipeline. We introduce a novel approach called Locally-Subdivided Neural Intersection Function (LSNIF) that replaces…

Graphics · Computer Science 2025-05-01 Shin Fujieda , Chih-Chen Kao , Takahiro Harada

MINFLUX (Minimal Photon Flux) is a single-molecule imaging technique capable of resolving fluorophores at a precision of <5 nm. Interpretation of the point patterns generated by this technique presents challenges due to variable emitter…

Applications · Statistics 2026-02-24 Jack Peyton , Benjamin Davis , Emily Gribbin , Daniel Rolfe , Hannah Mitchell

Single-molecule localization fluorescence microscopy constructs super-resolution images by sequential imaging and computational localization of sparsely activated fluorophores. Accurate and efficient fluorophore localization algorithms are…

Image and Video Processing · Electrical Eng. & Systems 2020-07-21 Artur Speiser , Lucas-Raphael Müller , Ulf Matti , Christopher J. Obara , Wesley R. Legant , Jonas Ries , Jakob H. Macke , Srinivas C. Turaga

Single-cell RNA sequencing (scRNA-seq) reveals cell heterogeneity, with cell clustering playing a key role in identifying cell types and marker genes. Recent advances, especially graph neural networks (GNNs)-based methods, have…

Genomics · Quantitative Biology 2025-10-03 Ping Xu , Zhiyuan Ning , Pengjiang Li , Wenhao Liu , Pengyang Wang , Jiaxu Cui , Yuanchun Zhou , Pengfei Wang

Volumetric image segmentation with convolutional neural networks (CNNs) encounters several challenges, which are specific to medical images. Among these challenges are large volumes of interest, high class imbalances, and difficulties in…

Computer Vision and Pattern Recognition · Computer Science 2019-11-12 Fabian Balsiger , Yannick Soom , Olivier Scheidegger , Mauricio Reyes

Predicting the secondary structure of RNA is a core challenge in computational biology, essential for understanding molecular function and designing novel therapeutics. The field has evolved from foundational but accuracy-limited…

Biomolecules · Quantitative Biology 2026-05-20 Giuseppe Sacco , Giovanni Bussi , Guido Sanguinetti

The increased availability of massive point clouds coupled with their utility in a wide variety of applications such as robotics, shape synthesis, and self-driving cars has attracted increased attention from both industry and academia.…

Machine Learning · Computer Science 2020-09-30 Charu Sharma , Manohar Kaul

3D point cloud semantic segmentation aims to group all points into different semantic categories, which benefits important applications such as point cloud scene reconstruction and understanding. Existing supervised point cloud semantic…

Computer Vision and Pattern Recognition · Computer Science 2023-03-29 Canyu Zhang , Zhenyao Wu , Xinyi Wu , Ziyu Zhao , Song Wang

Single-cell RNA sequencing (scRNA-seq), especially temporally resolved datasets, enables genome-wide profiling of gene expression dynamics at single-cell resolution across discrete time points. However, current technologies provide only…

Genomics · Quantitative Biology 2025-11-19 Yue Ling , Peiqi Zhang , Zhenyi Zhang , Peijie Zhou

Advances in cellular imaging technologies, especially those based on fluorescence in situ hybridization (FISH) now allow detailed visualization of the spatial organization of human or bacterial cells. Quantifying this spatial organization…

This paper describes a micro fluorescence in situ hybridization ({\mu}FISH)-based rapid detection of cytogenetic biomarkers on formalin-fixed paraffin embedded (FFPE) tissue sections. We demonstrated this method in the context of detecting…

Tissues and Organs · Quantitative Biology 2018-06-19 Deborah Huber , Govind V. Kaigala

In recent years, the advances in single-cell RNA-seq techniques have enabled us to perform large-scale transcriptomic profiling at single-cell resolution in a high-throughput manner. Unsupervised learning such as data clustering has become…

Genomics · Quantitative Biology 2020-01-07 Shixiong Zhang , Xiangtao Li , Qiuzhen Lin , Ka-Chun Wong

Super-resolution microscopy has catalyzed valuable insights into the sub-cellular, mechanistic details of many different biological processes across a wide range of cell types. Fluorescence polarization spectroscopy tools have also enabled…

Biological Physics · Physics 2023-01-25 Jack W Shepherd , Alex L Payne-Dwyer , Ji-Eun Lee , Aisha Syeda , Mark C Leake

Karyotyping is a process in which chromosomes in a dividing cell are properly stained, identified and displayed in a standard format, which helps geneticist to study and diagnose genetic factors behind various genetic diseases and for…

Computer Vision and Pattern Recognition · Computer Science 2012-05-10 K. S. Sreejini , A. Lijiya , V. K. Govindan

Recent years have witnessed the surge of learned representations that directly build upon point clouds. Though becoming increasingly expressive, most existing representations still struggle to generate ordered point sets. Inspired by…

Computer Vision and Pattern Recognition · Computer Science 2023-02-06 Jiaxin Wei , Lige Liu , Ran Cheng , Wenqing Jiang , Minghao Xu , Xinyu Jiang , Tao Sun , Soren Schwertfeger , Laurent Kneip

Semantic segmentation is an important and well-known task in the field of computer vision, in which we attempt to assign a corresponding semantic class to each input element. When it comes to semantic segmentation of 2D images, the input…

Computer Vision and Pattern Recognition · Computer Science 2023-05-02 Ivan Martinović