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Artificial intelligence (AI) systems utilizing deep neural networks (DNNs) and machine learning (ML) algorithms are widely used for solving important problems in bioinformatics, biomedical informatics, and precision medicine. However,…

Quantitative Methods · Quantitative Biology 2023-02-24 Md. Rezaul Karim , Tanhim Islam , Oya Beyan , Christoph Lange , Michael Cochez , Dietrich Rebholz-Schuhmann , Stefan Decker

Large Language Models (LLMs) have played a pivotal role in advancing Artificial Intelligence (AI). However, despite their achievements, LLMs often struggle to explain their decision-making processes, making them a 'black box' and presenting…

Computation and Language · Computer Science 2025-06-30 Avash Palikhe , Zhenyu Yu , Zichong Wang , Wenbin Zhang

The integration of artificial intelligence (AI) into medicine is remarkable, offering advanced diagnostic and therapeutic possibilities. However, the inherent opacity of complex AI models presents significant challenges to their clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Binbin Wen , Yihang Wu , Tareef Daqqaq , Ahmad Chaddad

Deep Learning has already been successfully applied to analyze industrial sensor data in a variety of relevant use cases. However, the opaque nature of many well-performing methods poses a major obstacle for real-world deployment.…

Machine Learning · Computer Science 2023-10-20 Thomas Decker , Michael Lebacher , Volker Tresp

Recent advancements in machine learning and signal processing domains have resulted in an extensive surge of interest in Deep Neural Networks (DNNs) due to their unprecedented performance and high accuracy for different and challenging…

Machine Learning · Computer Science 2021-02-04 Atefeh Shahroudnejad

The diffusion of artificial intelligence (AI) applications in organizations and society has fueled research on explaining AI decisions. The explainable AI (xAI) field is rapidly expanding with numerous ways of extracting information and…

Human-Computer Interaction · Computer Science 2021-01-27 Julie Gerlings , Arisa Shollo , Ioanna Constantiou

As the use of deep learning techniques has grown across various fields over the past decade, complaints about the opaqueness of the black-box models have increased, resulting in an increased focus on transparency in deep learning models.…

Computation and Language · Computer Science 2024-03-19 Siwen Luo , Hamish Ivison , Caren Han , Josiah Poon

Explainable AI (XAI) techniques are increasingly important for the validation and responsible use of modern deep learning models, but are difficult to evaluate due to the lack of good ground-truth to compare against. We propose a framework…

Artificial Intelligence · Computer Science 2026-05-19 Amritpal Singh , Andrey Barsky , Mohamed Ali Souibgui , Ernest Valveny , Dimosthenis Karatzas

Many Machine Learning algorithms, such as deep neural networks, have long been criticized for being "black-boxes"-a kind of models unable to provide how it arrive at a decision without further efforts to interpret. This problem has raised…

Machine Learning · Statistics 2019-07-04 Yihuang Kang , I-Ling Cheng , Wenjui Mao , Bowen Kuo , Pei-Ju Lee

Last years have been characterized by an upsurge of opaque automatic decision support systems, such as Deep Neural Networks (DNNs). Although they have great generalization and prediction skills, their functioning does not allow obtaining…

Spectral-based machine learning models have been increasingly deployed in chemometrics and spectroscopy, where predictive accuracy is as important as explainability. Current employed eXplainable Artificial Intelligence (XAI) methods are…

Machine Learning · Computer Science 2026-05-05 Jose Vinicius Ribeiro , Rafael Figueira Goncalves , Fabio Luiz Melquiades , Sylvio Barbon Junior

Ensuring transparency and trust in artificial intelligence (AI) models is essential as they are increasingly deployed in safety-critical and high-stakes domains. Explainable AI (XAI) has emerged as a promising approach to address this…

Computer Vision and Pattern Recognition · Computer Science 2025-11-05 Reem Hammoud , Abdul Karim Gizzini , Ali J. Ghandour

LangXAI is a framework that integrates Explainable Artificial Intelligence (XAI) with advanced vision models to generate textual explanations for visual recognition tasks. Despite XAI advancements, an understanding gap persists for…

Computer Vision and Pattern Recognition · Computer Science 2024-02-21 Truong Thanh Hung Nguyen , Tobias Clement , Phuc Truong Loc Nguyen , Nils Kemmerzell , Van Binh Truong , Vo Thanh Khang Nguyen , Mohamed Abdelaal , Hung Cao

Language Models (LMs) have significantly advanced natural language processing and enabled remarkable progress across diverse domains, yet their black-box nature raises critical concerns about the interpretability of their internal…

Computation and Language · Computer Science 2025-09-29 Avash Palikhe , Zichong Wang , Zhipeng Yin , Rui Guo , Qiang Duan , Jie Yang , Wenbin Zhang

This chapter discusses the opportunities of eXplainable Artificial Intelligence (XAI) within the realm of spatial analysis. A key objective in spatial analysis is to model spatial relationships and infer spatial processes to generate…

Machine Learning · Computer Science 2025-05-02 Ziqi Li

Although modern machine learning and deep learning methods allow for complex and in-depth data analytics, the predictive models generated by these methods are often highly complex, and lack transparency. Explainable AI (XAI) methods are…

Machine Learning · Computer Science 2021-06-17 Mythreyi Velmurugan , Chun Ouyang , Catarina Moreira , Renuka Sindhgatta

The black box nature of deep neural networks poses a significant challenge for the deployment of transparent and trustworthy artificial intelligence (AI) systems. With the growing presence of AI in society, it becomes increasingly important…

Machine Learning · Computer Science 2025-11-25 Bianka Kowalska , Halina Kwaśnicka

In recent years, machine learning (ML) has become a key enabling technology for the sciences and industry. Especially through improvements in methodology, the availability of large databases and increased computational power, today's ML…

Artificial Intelligence · Computer Science 2019-09-27 Wojciech Samek , Klaus-Robert Müller

Artificial intelligence has become pervasive across disciplines and fields, and biomedical image and signal processing is no exception. The growing and widespread interest on the topic has triggered a vast research activity that is…

Machine Learning · Computer Science 2022-07-12 Guang Yang , Arvind Rao , Christine Fernandez-Maloigne , Vince Calhoun , Gloria Menegaz