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Longitudinal and time-to-event data are often analyzed in biomarker research to study the association between the longitudinal biomarker measurements and the event-time outcome, in which the longitudinal information contributes to the…

Methodology · Statistics 2025-09-09 Minzee Kim , Joel A. Dubin

Knowledge of the time at which an HIV-infected individual seroconverts, when the immune system starts responding to HIV infection, plays a vital role in the design and implementation of interventions to reduce the impact of the HIV…

Applications · Statistics 2017-06-09 Loumpiana Koulai , Anne Presanis , Gary Murphy , Barbara Suligoi , Daniela De Angelis

This study investigates the relationship between longitudinal serum creatinine measurements and the risk of adverse kidney outcomes in paediatric patients with auto-immune disorders at Great Ormond Street Hospital for Children NHS…

Researchers are often faced with evaluating the effect of a policy or program that was simultaneously initiated across an entire population of units at a single point in time, and its effects over the targeted population can manifest at any…

Joint models for longitudinal biomarkers and time-to-event data are widely used in longitudinal studies. Many joint modeling approaches have been proposed to deal with different types of longitudinal biomarkers and survival outcomes.…

Methodology · Statistics 2016-09-27 Molei Liu , Jiehuan Sun , Jose D. Herazo-Maya , Naftali Kaminski , Hongyu Zhao

Causal inference in observational studies typically requires making comparisons between groups that are dissimilar. For instance, researchers investigating the role of a prolonged duration of breastfeeding on child outcomes may be forced to…

Applications · Statistics 2013-12-02 Jennifer Hill , Yu-Sung Su

Accurately predicting blood glucose (BG) levels of ICU patients is critical, as both hypoglycemia (BG < 70 mg/dL) and hyperglycemia (BG > 180 mg/dL) are associated with increased morbidity and mortality. This study presents a…

Machine Learning · Computer Science 2025-06-24 Hadi Mehdizavareh , Arijit Khan , Simon Lebech Cichosz

Major postoperative complications are devastating to surgical patients. Some of these complications are potentially preventable via early predictions based on intraoperative data. However, intraoperative data comprise long and fine-grained…

Machine Learning · Computer Science 2022-10-11 Dingwen Li , Bing Xue , Christopher King , Bradley Fritz , Michael Avidan , Joanna Abraham , Chenyang Lu

We develop a model using deep learning techniques and natural language processing on unstructured text from medical records to predict hospital-wide $30$-day unplanned readmission, with c-statistic $.70$. Our model is constructed to allow…

Machine Learning · Statistics 2017-12-21 Erin Craig , Carlos Arias , David Gillman

The adoption of deep learning in healthcare is hindered by their "black box" nature. In this paper, we explore the RETAIN architecture for the task of glusose forecasting for diabetic people. By using a two-level attention mechanism, the…

Machine Learning · Computer Science 2020-09-09 Maxime De Bois , Mounîm A. El Yacoubi , Mehdi Ammi

Joint models for longitudinal and survival data have become a popular framework for studying the association between repeatedly measured biomarkers and clinical events. Nevertheless, addressing complex survival data structures, especially…

Hospital readmissions following coronary artery bypass grafting (CABG) not only impose a substantial cost burden on healthcare systems but also serve as a potential indicator of the quality of medical care. Previous studies of gender…

Applications · Statistics 2025-08-21 Henan Xu , Yeying Zhu , Donna L. Coffman

Readmission after discharge from a hospital is disruptive and costly, regardless of the reason. However, it can be particularly problematic for psychiatric patients, so predicting which patients may be readmitted is critically important but…

Computation and Language · Computer Science 2018-09-18 Eben Holderness , Nicholas Miller , Philip Cawkwell , Kirsten Bolton , James Pustejovsky , Marie Meteer , Mei-Hua Hall

Prognostication for comatose post-cardiac arrest patients is a critical challenge that directly impacts clinical decision-making in the ICU. Clinical information that informs prognostication is collected serially over time. Shortly after…

Machine Learning · Computer Science 2025-08-11 Xiaobin Shen , Jonathan Elmer , George H. Chen

Predicting which patients are more likely to be readmitted to a hospital within 30 days after discharge is a valuable piece of information in clinical decision-making. Building a successful readmission risk classifier based on the content…

Recurrent binary outcomes within individuals, such as hospital readmissions, often reflect latent risk processes that evolve over time. Conventional methods like generalized linear mixed models and generalized estimating equations estimate…

Methodology · Statistics 2026-02-24 Niloofar Ramezani , Lori P. Selby , Pascal Nitiema , Jeffrey R. Wilson

Nonlinear mixed effects models represent a powerful tool to simultaneously analyze data from several individuals. In this study a compartmental model of leucine kinetics is examined and extended with a stochastic differential equation to…

Quantitative Methods · Quantitative Biology 2011-01-05 Martin Berglund , Mikael Sunnåker , Martin Adiels , Mats Jirstrand , Bernt Wennberg

In this article, we use multilevel multinomial logistic regression model to identify the risk factors of anemia in children of northeastern States of India. The data consisted of 10,136 children of age group 6-59 months. We considered the…

Applications · Statistics 2015-04-14 Sanku Dey , Enayetur Raheem

In a clinical trial of a treatment for alcoholism, a common response variable of interest is the number of alcoholic drinks consumed by each subject each day, or an ordinal version of this response, with levels corresponding to abstinence,…

Applications · Statistics 2010-10-08 Kenneth E. Shirley , Dylan S. Small , Kevin G. Lynch , Stephen A. Maisto , David W. Oslin

In healthcare, patient risk stratification models are often learned using time-series data extracted from electronic health records. When extracting data for a clinical prediction task, several formulations exist, depending on how one…

Machine Learning · Computer Science 2018-12-03 Eli Sherman , Hitinder Gurm , Ulysses Balis , Scott Owens , Jenna Wiens
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