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Tree ensembles are very popular machine learning models, known for their effectiveness in supervised classification and regression tasks. Their performance derives from aggregating predictions of multiple decision trees, which are renowned…

Optimization and Control · Mathematics 2025-01-14 Lorenzo Bonasera , Emilio Carrizosa

In this work, we introduce a new information-theoretic perspective on Multiple Instance Learning (MIL) for parameter estimation with i.i.d. data, and show that MIL can outperform single-instance learners in low-signal regimes. Prior work…

Machine Learning · Computer Science 2025-12-03 Atakan Azakli , Bernd Stelzer

Multiple instance learning (MIL) is the preferred approach for whole slide image classification. However, most MIL approaches do not exploit the interdependencies of tiles extracted from a whole slide image, which could provide valuable…

Computer Vision and Pattern Recognition · Computer Science 2021-08-26 Marvin Lerousseau , Maria Vakalopoulou , Eric Deutsch , Nikos Paragios

The interpretability of models has become a crucial issue in Machine Learning because of algorithmic decisions' growing impact on real-world applications. Tree ensemble methods, such as Random Forests or XgBoost, are powerful learning tools…

Optimization and Control · Mathematics 2024-01-19 Giulia Di Teodoro , Marta Monaci , Laura Palagi

Multiple instance learning (MIL) was a weakly supervised learning approach that sought to assign binary class labels to collections of instances known as bags. However, due to their weak supervision nature, the MIL methods were susceptible…

Computer Vision and Pattern Recognition · Computer Science 2024-05-27 Wenhui Zhu , Peijie Qiu , Xiwen Chen , Oana M. Dumitrascu , Yalin Wang

Multiple instance learning (MIL) aims to learn the mapping between a bag of instances and the bag-level label. In this paper, we propose a new end-to-end graph neural network (GNN) based algorithm for MIL: we treat each bag as a graph and…

Machine Learning · Computer Science 2019-06-13 Ming Tu , Jing Huang , Xiaodong He , Bowen Zhou

\textit{Multiple Instance Learning} (MIL) is concerned with learning from bags of instances, where only bag labels are given and instance labels are unknown. Existent approaches in this field were mainly designed for the bag-level label…

Machine Learning · Computer Science 2019-05-30 Minlong Peng , Qi Zhang

Multiple instance learning (MIL) is a robust paradigm for whole-slide pathological image (WSI) analysis, processing gigapixel-resolution images with slide-level labels. As pioneering efforts, attention-based MIL (ABMIL) and its variants are…

Computer Vision and Pattern Recognition · Computer Science 2024-04-02 Linghan Cai , Shenjin Huang , Ye Zhang , Jinpeng Lu , Yongbing Zhang

The use of machine learning algorithms in finance, medicine, and criminal justice can deeply impact human lives. As a consequence, research into interpretable machine learning has rapidly grown in an attempt to better control and fix…

Machine Learning · Computer Science 2021-02-02 Thibaut Vidal , Toni Pacheco , Maximilian Schiffer

The dynamic environment of laboratories and clinics, with streams of data arriving on a daily basis, requires regular updates of trained machine learning models for consistent performance. Continual learning is supposed to help train models…

Machine Learning · Computer Science 2025-08-12 Zahra Ebrahimi , Raheleh Salehi , Nassir Navab , Carsten Marr , Ario Sadafi

Multiple Instance Learning (MIL) plays a significant role in computational pathology, enabling weakly supervised analysis of Whole Slide Image (WSI) datasets. The field of WSI analysis is confronted with a severe long-tailed distribution…

Computer Vision and Pattern Recognition · Computer Science 2025-03-04 Xitong Ling , Yifeng Ping , Jiawen Li , Jing Peng , Yuxuan Chen , Minxi Ouyang , Yizhi Wang , Yonghong He , Tian Guan , Xiaoping Liu , Lianghui Zhu

The aim of multimodal neural networks is to combine diverse data sources, referred to as modalities, to achieve enhanced performance compared to relying on a single modality. However, training of multimodal networks is typically hindered by…

Machine Learning · Computer Science 2025-10-21 Alejandro Guerra-Manzanares , Farah E. Shamout

Multiple Instance Learning (MIL) is a cornerstone approach in computational pathology (CPath) for generating clinically meaningful slide-level embeddings from gigapixel tissue images. However, MIL often struggles with small, weakly…

Computer Vision and Pattern Recognition · Computer Science 2025-06-12 Daniel Shao , Richard J. Chen , Andrew H. Song , Joel Runevic , Ming Y. Lu , Tong Ding , Faisal Mahmood

Whole slide image (WSI) classification is a fundamental task for the diagnosis and treatment of diseases; but, curation of accurate labels is time-consuming and limits the application of fully-supervised methods. To address this, multiple…

Computer Vision and Pattern Recognition · Computer Science 2022-07-25 Philip Chikontwe , Soo Jeong Nam , Heounjeong Go , Meejeong Kim , Hyun Jung Sung , Sang Hyun Park

Multiple Instance Learning (MIL) has been widely used in weakly supervised whole slide image (WSI) classification. Typical MIL methods include a feature embedding part, which embeds the instances into features via a pre-trained feature…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Peijie Qiu , Pan Xiao , Wenhui Zhu , Yalin Wang , Aristeidis Sotiras

In this work, we propose a simple model that provides permutation invariant maximally predictive prototype generator from a given dataset, which leads to interpretability of the solution and concrete insights to the nature and the solution…

Machine Learning · Computer Science 2021-01-25 Mert Yuksekgonul , Ozgur Emre Sivrikaya , Mustafa Gokce Baydogan

One of the current challenges in machine learning is how to deal with data coming at increasing rates in data streams. New predictive learning strategies are needed to cope with the high throughput data and concept drift. One of the data…

Multiple Instance Learning (MIL) has demonstrated promise in Whole Slide Image (WSI) classification. However, a major challenge persists due to the high computational cost associated with processing these gigapixel images. Existing methods…

Computer Vision and Pattern Recognition · Computer Science 2023-12-05 Hongyi Wang , Luyang Luo , Fang Wang , Ruofeng Tong , Yen-Wei Chen , Hongjie Hu , Lanfen Lin , Hao Chen

Tree-based models are used in many high-stakes application domains such as finance and medicine, where robustness and interpretability are of utmost importance. Yet, methods for improving and certifying their robustness are severely…

Machine Learning · Computer Science 2022-11-16 Miklós Z. Horváth , Mark Niklas Müller , Marc Fischer , Martin Vechev

This paper examines the stability of learned explanations for black-box predictions via model distillation with decision trees. One approach to intelligibility in machine learning is to use an understandable `student' model to mimic the…

Machine Learning · Statistics 2018-08-24 Yichen Zhou , Zhengze Zhou , Giles Hooker
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