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A diffusion probabilistic model (DPM), which constructs a forward diffusion process by gradually adding noise to data points and learns the reverse denoising process to generate new samples, has been shown to handle complex data…

Computer Vision and Pattern Recognition · Computer Science 2023-10-16 Zhengxiong Luo , Dayou Chen , Yingya Zhang , Yan Huang , Liang Wang , Yujun Shen , Deli Zhao , Jingren Zhou , Tieniu Tan

Recent advances in imaging and high-performance computing have made it possible to image the entire human brain at the cellular level. This is the basis to study the multi-scale architecture of the brain regarding its subdivision into brain…

Image and Video Processing · Electrical Eng. & Systems 2023-11-29 Jan-Oliver Kropp , Christian Schiffer , Katrin Amunts , Timo Dickscheid

Denoising Probabilistic Models (DPMs) represent an emerging domain of generative models that excel in generating diverse and high-quality images. However, most current training methods for DPMs often neglect the correlation between…

Computer Vision and Pattern Recognition · Computer Science 2024-02-01 Viet Nguyen , Giang Vu , Tung Nguyen Thanh , Khoat Than , Toan Tran

In this work, we address two major issues in recent Denoising Diffusion Probabilistic Models (DDPM): {\bf 1)} geometric key feature extraction and {\bf 2)} network equivariance. Since the DDPM prediction network relies on the U-net…

Computer Vision and Pattern Recognition · Computer Science 2026-02-12 El Hadji S. Diop , Thierno Fall , Mohamed Daoudi

SDE-based methods such as denoising diffusion probabilistic models (DDPMs) have shown remarkable success in real-world sample generation tasks. Prior analyses of DDPMs have been focused on the exponential Euler discretization, showing…

Machine Learning · Computer Science 2025-11-10 Matthew S. Zhang , Stephen Huan , Jerry Huang , Nicholas M. Boffi , Sitan Chen , Sinho Chewi

Denoising diffusion probabilistic models (DDPMs) have achieved unprecedented success in computer vision. However, they remain underutilized in medical imaging, a field crucial for disease diagnosis and treatment planning. This is primarily…

Image and Video Processing · Electrical Eng. & Systems 2025-08-22 Hongxu Jiang , Muhammad Imran , Teng Zhang , Yuyin Zhou , Muxuan Liang , Kuang Gong , Wei Shao

Bayesian models based on Gaussian processes (GPs) offer a flexible framework to predict spatially distributed variables with uncertainty. But the use of nonstationary priors, often necessary for capturing complex spatial patterns, makes…

Machine Learning · Statistics 2025-06-02 Gabriel V Cardoso , Mike Pereira

The performance of pre-trained masked diffusion models is often constrained by their sampling procedure, which makes decisions irreversible and struggles in low-step generation regimes. We introduce a novel sampling algorithm that works…

We show that a Denoising Diffusion Probabalistic Model (DDPM), a class of score-based generative model, can be used to produce realistic mock images that mimic observations of galaxies. Our method is tested with Dark Energy Spectroscopic…

Instrumentation and Methods for Astrophysics · Physics 2022-02-01 Michael J. Smith , James E. Geach , Ryan A. Jackson , Nikhil Arora , Connor Stone , Stéphane Courteau

This paper investigates score-based diffusion models when the underlying target distribution is concentrated on or near low-dimensional manifolds within the higher-dimensional space in which they formally reside, a common characteristic of…

Machine Learning · Computer Science 2025-01-03 Gen Li , Yuling Yan

Denoising diffusion models are a popular class of generative models providing state-of-the-art results in many domains. One adds gradually noise to data using a diffusion to transform the data distribution into a Gaussian distribution.…

Machine Learning · Computer Science 2023-08-21 Francisco Vargas , Will Grathwohl , Arnaud Doucet

Advances in microscopy imaging enable researchers to visualize structures at the nanoscale level thereby unraveling intricate details of biological organization. However, challenges such as image noise, photobleaching of fluorophores, and…

Image and Video Processing · Electrical Eng. & Systems 2024-09-19 Pamela Osuna-Vargas , Maren H. Wehrheim , Lucas Zinz , Johanna Rahm , Ashwin Balakrishnan , Alexandra Kaminer , Mike Heilemann , Matthias Kaschube

This paper studies the original discrete-time denoising diffusion probabilistic model (DDPM) from a probabilistic point of view. We present three main theoretical results. First, we show that the time-dependent score function associated…

Probability · Mathematics 2026-01-13 Yumiharu Nakano

Denoising diffusion probabilistic models (DDPMs) are a recent family of generative models that achieve state-of-the-art results. In order to obtain class-conditional generation, it was suggested to guide the diffusion process by gradients…

Computer Vision and Pattern Recognition · Computer Science 2023-03-17 Bahjat Kawar , Roy Ganz , Michael Elad

We study Diffusion Schr\"odinger Bridge (DSB) models in the context of dynamical astrophysical systems, specifically tackling observational inverse prediction tasks within Giant Molecular Clouds (GMCs) for star formation. We introduce the…

Instrumentation and Methods for Astrophysics · Physics 2025-11-13 Ye Zhu , Duo Xu , Zhiwei Deng , Jonathan C. Tan , Olga Russakovsky

Diffusion models produce high-quality synthetic data but suffer from slow inference. We propose 3D Variable-Step Denoising Diffusion Probabilistic Model (VS-DDPM) a framework engineered to maintain generative quality while accelerating…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Nikoo Moradi , Gijs Luijten , Behrus Hinrichs-Puladi , Jens Kleesiek , Victor Alves , Jan Egger , André Ferreira

Deep generative models are key-enabling technology to computer vision, text generation, and large language models. Denoising diffusion probabilistic models (DDPMs) have recently gained much attention due to their ability to generate diverse…

Quantum Physics · Physics 2026-02-02 Bingzhi Zhang , Peng Xu , Xiaohui Chen , Quntao Zhuang

Diffusion Probabilistic Models (DPMs) are powerful generative models that have achieved unparalleled success in a number of generative tasks. In this work, we aim to build inductive biases into the training and sampling of diffusion models…

Machine Learning · Computer Science 2025-03-14 Thomas Jiralerspong , Berton Earnshaw , Jason Hartford , Yoshua Bengio , Luca Scimeca

Despite the proliferation of generative models, achieving fast sampling during inference without compromising sample diversity and quality remains challenging. Existing models such as Denoising Diffusion Probabilistic Models (DDPM) deliver…

Machine Learning · Computer Science 2023-10-12 Yanwu Xu , Mingming Gong , Shaoan Xie , Wei Wei , Matthias Grundmann , Kayhan Batmanghelich , Tingbo Hou

Denoising Diffusion Probabilistic Models (DDPMs) can generate high-quality samples such as image and audio samples. However, DDPMs require hundreds to thousands of iterations to produce final samples. Several prior works have successfully…

Computer Vision and Pattern Recognition · Computer Science 2022-11-01 Luping Liu , Yi Ren , Zhijie Lin , Zhou Zhao