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The limited extrapolative power of structure-based machine learning (ML) models is a critical bottleneck in chemical discovery, particularly for industrial R&D, where navigating uncharted chemical space to find next-generation materials or…

Coarse-grained modeling in molecular simulations serves not only to extend accessible time and length scales beyond atomistic limits, but also to reduce high-dimensional chemical data to low-dimensional representations that expose the…

Chemical Physics · Physics 2026-05-19 Michael N. Sakano , Alejandro Strachan

We propose an efficient approach for simultaneous prediction of thermal and electronic transport properties in complex materials. Firstly, a highly efficient machine-learned neuroevolution potential is trained using reference data from…

Materials Science · Physics 2024-04-08 Zheyong Fan , Yang Xiao , Yanzhou Wang , Penghua Ying , Shunda Chen , Haikuan Dong

Machine learning force fields show great promise in enabling more accurate molecular dynamics simulations compared to manually derived ones. Much of the progress in recent years was driven by exploiting prior knowledge about physical…

Machine Learning · Computer Science 2025-09-11 Andreas Burger , Luca Thiede , Alán Aspuru-Guzik , Nandita Vijaykumar

We investigate the problem of how to obtain the force field between atoms of an experimentally determined structure. We show how this problem can be efficiently solved, even at finite temperature, where the position of the atoms differs…

Condensed Matter · Physics 2009-10-28 J. M. Deutsch , Tanya Kurosky

Sampling complex free energy surfaces is one of the main challenges of modern atomistic simulation methods. The presence of kinetic bottlenecks in such surfaces often renders a direct approach useless. A popular strategy is to identify a…

Computational Physics · Physics 2019-09-25 Luigi Bonati , Yue-Yu Zhang , Michele Parrinello

We have developed a neural network potential energy function for use in drug discovery, with chemical element support extended from 41% to 94% of druglike molecules based on ChEMBL. We expand on the work of Smith et al., with their highly…

Buildings sector is one of the major consumers of energy in the United States. The buildings HVAC (Heating, Ventilation, and Air Conditioning) systems, whose functionality is to maintain thermal comfort and indoor air quality (IAQ), account…

Systems and Control · Electrical Eng. & Systems 2021-03-24 Chi Zhang , Sanmukh R. Kuppannagari , Rajgopal Kannan , Viktor K. Prasanna

Determining thermal and physical quantities across a broad temperature domain, especially up to the ultra-high temperature region, is a formidable theoretical and experimental challenge. At the same time it is essential for understanding…

Materials Science · Physics 2019-11-11 Yanhui Zhang , Alessandro Lunghi , Stefano Sanvito

Chemically reacting flows are common in engineering, such as hypersonic flow, combustion, explosions, manufacturing processes and environmental assessments. For combustion, the number of reactions can be significant (over 100) and due to…

Machine Learning · Computer Science 2021-04-06 Thomas S. Brown , Harbir Antil , Rainald Löhner , Fumiya Togashi , Deepanshu Verma

A novel approach is presented for the solution of instantaneous chemical equilibrium problems. The chemical equilibrium can be considered, due to its intrinsically local character, as a mapping of the three-dimensional parameter space…

Astrophysics · Physics 2009-11-11 A. Asensio Ramos , H. Socas-Navarro

Dynamic analysis of structures subjected to earthquake excitation is a time-consuming process, particularly in the case of extremely small time step required, or in the presence of high geometric and material nonlinearity. Performing…

Machine Learning · Computer Science 2021-11-30 Xiao Pan , Zhizhao Wen , T. Y. Yang

Reaction mechanism search tools have demonstrated the ability to provide insights into likely products and rate-limiting steps of reacting systems. However, reactions involving several concerted bond changes - as can be found in many key…

Machine Learning · Computer Science 2025-10-15 Nicholas Casetti , Dylan Anstine , Olexandr Isayev , Connor W. Coley

Machine learning techniques are essential tools to compute efficient, yet accurate, force fields for atomistic simulations. This approach has recently been extended to incorporate quantum computational methods, making use of variational…

Fast and accurate structural dynamics analysis is important for structural design and damage assessment. Structural dynamics analysis leveraging machine learning techniques has become a popular research focus in recent years. Although the…

Geophysics · Physics 2020-12-29 Yuan Feng , Hexiang Wang , Han Yang , Fangbo Wang

Estimating accurate forward and inverse dynamics models is a crucial component of model-based control for sophisticated robots such as robots driven by hydraulics, artificial muscles, or robots dealing with different contact situations.…

Deep learning has led to a paradigm shift in artificial intelligence, including web, text and image search, speech recognition, as well as bioinformatics, with growing impact in chemical physics. Machine learning in general and deep…

Accurately measuring magnetic fields is essential for magnetic-field sensitive experiments in fields like atomic, molecular, and optical physics, condensed matter experiments, and other areas. However, since many experiments are conducted…

Instrumentation and Detectors · Physics 2023-05-31 Ziting Chen , Kin To Wong , Bojeong Seo , Mingchen Huang , Mithilesh K. Parit , Haoting Zhen , Jensen Li , Gyu-Boong Jo

The discovery of very large piezo- and pyroelectric effects in ZrO2 and HfO2-based thin films opens up new opportunities to develop silicon-compatible sensor and actor devices. The effects are amplified close to the polar-orthorhombic to…

Materials Science · Physics 2022-06-02 Richard Ganser , Simon Bongarz , Alexander von Mach , Luis Azevedo Antunes , Alfred Kersch

The increased energy and power density required in modern electronics poses a challenge for designing new dielectric polymer materials with high energy density while maintaining low loss at high applied electric fields. Recently, an…

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