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We present an autoencoder that leverages learned representations to better measure similarities in data space. By combining a variational autoencoder with a generative adversarial network we can use learned feature representations in the…

Machine Learning · Computer Science 2016-02-12 Anders Boesen Lindbo Larsen , Søren Kaae Sønderby , Hugo Larochelle , Ole Winther

Protein function is inherently linked to its localization within the cell, and fluorescent microscopy data is an indispensable resource for learning representations of proteins. Despite major developments in molecular representation…

Quantitative Methods · Quantitative Biology 2022-05-25 Anastasia Razdaibiedina , Alexander Brechalov

Anomaly detection using dimensionality reduction has been an essential technique for monitoring multidimensional data. Although deep learning-based methods have been well studied for their remarkable detection performance, their…

Machine Learning · Statistics 2018-12-24 Yasuhiro Ikeda , Kengo Tajiri , Yuusuke Nakano , Keishiro Watanabe , Keisuke Ishibashi

We present a novel method for characterizing the microstructure of a material from volumetric datasets such as 3D image data from computed tomography (CT). The method is based on a new statistical model for the distribution of voxel…

Materials Science · Physics 2021-01-06 Elise Otterlei Brenne , Vedrana Andersen Dahl , Peter Stanley Jørgensen

We introduce physics-informed multimodal autoencoders (PIMA) - a variational inference framework for discovering shared information in multimodal scientific datasets representative of high-throughput testing. Individual modalities are…

Machine Learning · Computer Science 2022-02-08 Nathaniel Trask , Carianne Martinez , Kookjin Lee , Brad Boyce

The manifold hypothesis states that high-dimensional data can be modeled as lying on or near a low-dimensional, nonlinear manifold. Variational Autoencoders (VAEs) approximate this manifold by learning mappings from low-dimensional latent…

Machine Learning · Statistics 2021-03-03 Marissa C. Connor , Gregory H. Canal , Christopher J. Rozell

Accelerated MRI protocols routinely involve a predefined sampling pattern that undersamples the k-space. Finding an optimal pattern can enhance the reconstruction quality, however this optimization is a challenging task. To address this…

Image and Video Processing · Electrical Eng. & Systems 2024-08-30 Cagan Alkan , Morteza Mardani , Congyu Liao , Zhitao Li , Shreyas S. Vasanawala , John M. Pauly

Sampling complex free energy surfaces is one of the main challenges of modern atomistic simulation methods. The presence of kinetic bottlenecks in such surfaces often renders a direct approach useless. A popular strategy is to identify a…

Computational Physics · Physics 2019-09-25 Luigi Bonati , Yue-Yu Zhang , Michele Parrinello

Autoencoders have found widespread application in both their original deterministic form and in their variational formulation (VAEs). In scientific applications and in image processing it is often of interest to consider data that are…

Machine Learning · Statistics 2025-09-09 Justin Bunker , Mark Girolami , Hefin Lambley , Andrew M. Stuart , T. J. Sullivan

Representation learning seeks to expose certain aspects of observed data in a learned representation that's amenable to downstream tasks like classification. For instance, a good representation for 2D images might be one that describes only…

Machine Learning · Computer Science 2017-03-07 Xi Chen , Diederik P. Kingma , Tim Salimans , Yan Duan , Prafulla Dhariwal , John Schulman , Ilya Sutskever , Pieter Abbeel

Real world datasets often contain entries with missing elements e.g. in a medical dataset, a patient is unlikely to have taken all possible diagnostic tests. Variational Autoencoders (VAEs) are popular generative models often used for…

Machine Learning · Computer Science 2021-03-23 Mark Collier , Alfredo Nazabal , Christopher K. I. Williams

In situ scanning transmission electron microscopy enables observation of the domain dynamics in ferroelectric materials as a function of externally applied bias and temperature. The resultant data sets contain a wealth of information on…

Harnessing the power of pre-training on large-scale datasets like ImageNet forms a fundamental building block for the progress of representation learning-driven solutions in computer vision. Medical images are inherently different from…

Computer Vision and Pattern Recognition · Computer Science 2023-08-01 Jeya Maria Jose Valanarasu , Yucheng Tang , Dong Yang , Ziyue Xu , Can Zhao , Wenqi Li , Vishal M. Patel , Bennett Landman , Daguang Xu , Yufan He , Vishwesh Nath

Variational Auto-Encoders have often been used for unsupervised pretraining, feature extraction and out-of-distribution and anomaly detection in the medical field. However, VAEs often lack the ability to produce sharp images and learn…

Machine Learning · Computer Science 2019-11-28 David Zimmerer , Jens Petersen , Klaus Maier-Hein

Error-bounded lossy compression is becoming an indispensable technique for the success of today's scientific projects with vast volumes of data produced during simulations or instrument data acquisitions. Not only can it significantly…

Machine Learning · Computer Science 2023-10-24 Jinyang Liu , Sheng Di , Kai Zhao , Sian Jin , Dingwen Tao , Xin Liang , Zizhong Chen , Franck Cappello

This work develops problem statements related to encoders and autoencoders with the goal of elucidating variational formulations and establishing clear connections to information-theoretic concepts. Specifically, four problems with varying…

Information Theory · Computer Science 2021-07-15 Karthik Duraisamy

Autoencoders are commonly trained using element-wise loss. However, element-wise loss disregards high-level structures in the image which can lead to embeddings that disregard them as well. A recent improvement to autoencoders that helps…

Computer Vision and Pattern Recognition · Computer Science 2020-04-06 Gustav Grund Pihlgren , Fredrik Sandin , Marcus Liwicki

Scientific archives now contain hundreds of petabytes of data across genomics, ecology, climate, and molecular biology that could reveal undiscovered patterns if systematically analyzed at scale. Large-scale, weakly-supervised datasets in…

Computer Vision and Pattern Recognition · Computer Science 2025-11-25 Samuel Stevens , Jacob Beattie , Tanya Berger-Wolf , Yu Su

A disentangled representation of a data set should be capable of recovering the underlying factors that generated it. One question that arises is whether using Euclidean space for latent variable models can produce a disentangled…

Machine Learning · Computer Science 2020-03-23 Luis A. Pérez Rey

Deep learning has made significant strides in medical imaging, leveraging the use of large datasets to improve diagnostics and prognostics. However, large datasets often come with inherent errors through subject selection and acquisition.…