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Deep convolutional neural networks are powerful tools for learning visual representations from images. However, designing efficient deep architectures to analyse volumetric medical images remains challenging. This work investigates…

Computer Vision and Pattern Recognition · Computer Science 2017-07-10 Wenqi Li , Guotai Wang , Lucas Fidon , Sebastien Ourselin , M. Jorge Cardoso , Tom Vercauteren

For the past decade, convolutional networks have been used for 3D reconstruction of neurons from electron microscopic (EM) brain images. Recent years have seen great improvements in accuracy, as evidenced by submissions to the SNEMI3D…

Computer Vision and Pattern Recognition · Computer Science 2017-06-02 Kisuk Lee , Jonathan Zung , Peter Li , Viren Jain , H. Sebastian Seung

Segmenting both bone surface and the corresponding acoustic shadow are fundamental tasks in ultrasound (US) guided orthopedic procedures. However, these tasks are challenging due to minimal and blurred bone surface response in US images,…

Image and Video Processing · Electrical Eng. & Systems 2022-06-22 Aimon Rahman , Jeya Maria Jose Valanarasu , Ilker Hacihaliloglu , Vishal M Patel

Automation of brain tumor segmentation in 3D magnetic resonance images (MRIs) is key to assess the diagnostic and treatment of the disease. In recent years, convolutional neural networks (CNNs) have shown improved results in the task.…

Image and Video Processing · Electrical Eng. & Systems 2021-01-01 Laura Mora Ballestar , Veronica Vilaplana

Developing automated and semi-automated solutions for reconstructing wiring diagrams of the brain from electron micrographs is important for advancing the field of connectomics. While the ultimate goal is to generate a graph of neuron…

Computer Vision and Pattern Recognition · Computer Science 2016-08-09 William Gray Roncal , Colin Lea , Akira Baruah , Gregory D. Hager

Methods for resolving the 3D microstructure of the brain typically start by thinly slicing and staining the brain, and then imaging each individual section with visible light photons or electrons. In contrast, X-rays can be used to image…

Reconstructing a map of neuronal connectivity is a critical challenge in contemporary neuroscience. Recent advances in high-throughput serial section electron microscopy (EM) have produced massive 3D image volumes of nanoscale brain tissue…

Being able to adequately process and combine data arising from different sites is crucial in neuroimaging, but is difficult, owing to site, sequence and acquisition-parameter dependent biases. It is important therefore to design algorithms…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Pedro Borges , Richard Shaw , Thomas Varsavsky , Kerstin Klaser , David Thomas , Ivana Drobnjak , Sebastien Ourselin , M Jorge Cardoso

This paper explores the use of a soft ground-truth mask ("soft mask'') to train a Fully Convolutional Neural Network (FCNN) for segmentation of Multiple Sclerosis (MS) lesions. Detection and segmentation of MS lesions is a complex task…

Computer Vision and Pattern Recognition · Computer Science 2019-01-29 Eytan Kats , Jacob Goldberger , Hayit Greenspan

Mammalian whole-brain connectomes are a foundational ingredient for holistic understanding of brains. Indeed, imaging connectomes at sufficient resolution to densely reconstruct cellular morphology and synapses represents a longstanding…

Neurons and Cognition · Quantitative Biology 2025-02-03 Logan Thrasher Collins , Todd Huffman , Randal Koene

Convolutional Neural Networks (CNNs) and Vision Transformers (ViT) have been pivotal in biomedical image segmentation, yet their ability to manage long-range dependencies remains constrained by inherent locality and computational overhead.…

Image and Video Processing · Electrical Eng. & Systems 2024-07-03 Tianrun Chen , Chaotao Ding , Lanyun Zhu , Tao Xu , Deyi Ji , Yan Wang , Ying Zang , Zejian Li

Morphology of mitochondria plays critical roles in mediating their physiological functions. Accurate segmentation of mitochondria from 3D electron microscopy (EM) images is essential to quantitative characterization of their morphology at…

Computer Vision and Pattern Recognition · Computer Science 2022-06-16 Yunpeng Xiao , Youpeng Zhao , Ge Yang

Accurate segmentation of neural structures in Electron Microscopy (EM) images is paramount for neuroscience. However, this task is challenged by intricate morphologies, low signal-to-noise ratios, and scarce annotations, limiting the…

Computer Vision and Pattern Recognition · Computer Science 2025-11-18 Zhenghua Li , Hang Chen , Zihao Sun , Kai Li , Xiaolin Hu

There are multiple scales of abstraction from which we can describe the same image, depending on whether we are focusing on fine-grained details or a more global attribute of the image. In brain mapping, learning to automatically parse…

Identifying complex neural circuitry from electron microscopic (EM) images may help unlock the mysteries of the brain. However, identifying this circuitry requires time-consuming, manual tracing (proofreading) due to the size and intricacy…

Quantitative Methods · Quantitative Biology 2014-09-04 Stephen M. Plaza

Precise 3D segmentation of infant brain tissues is an essential step towards comprehensive volumetric studies and quantitative analysis of early brain developement. However, computing such segmentations is very challenging, especially for…

Computer Vision and Pattern Recognition · Computer Science 2017-12-20 Jose Dolz , Christian Desrosiers , Li Wang , Jing Yuan , Dinggang Shen , Ismail Ben Ayed

We show dense voxel embeddings learned via deep metric learning can be employed to produce a highly accurate segmentation of neurons from 3D electron microscopy images. A "metric graph" on a set of edges between voxels is constructed from…

Computer Vision and Pattern Recognition · Computer Science 2021-08-09 Kisuk Lee , Ran Lu , Kyle Luther , H. Sebastian Seung

The morbidity of brain stroke increased rapidly in the past few years. To help specialists in lesion measurements and treatment planning, automatic segmentation methods are critically required for clinical practices. Recently, approaches…

Image and Video Processing · Electrical Eng. & Systems 2020-01-01 Kehan Qi , Hao Yang , Cheng Li , Zaiyi Liu , Meiyun Wang , Qiegen Liu , Shanshan Wang

Deep learning models are increasingly used for radiographic analysis, but their reliability is challenged by the stochastic noise inherent in clinical imaging. A systematic, cross-task understanding of how different noise types impact these…

Image and Video Processing · Electrical Eng. & Systems 2025-10-15 Derek Jiu , Kiran Nijjer , Nishant Chinta , Ryan Bui , Kevin Zhu

Neuron reconstruction, one of the fundamental tasks in neuroscience, rebuilds neuronal morphology from 3D light microscope imaging data. It plays a critical role in analyzing the structure-function relationship of neurons in the nervous…

Computer Vision and Pattern Recognition · Computer Science 2024-05-07 Yik San Cheng , Runkai Zhao , Heng Wang , Hanchuan Peng , Weidong Cai