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For the investigation of chemical reaction networks, the efficient and accurate determination of all relevant intermediates and elementary reactions is mandatory. The complexity of such a network may grow rapidly, in particular if reactive…

Chemical Physics · Physics 2016-01-08 Maike Bergeler , Gregor N. Simm , Jonny Proppe , Markus Reiher

Exact results for product-form stationary distributions of Markov chains are of interest in different fields. In stochastic reaction networks (CRNs), stationary distributions are mostly known in special cases where they are of product-form.…

Probability · Mathematics 2021-12-07 Beatriz Pascual-Escudero , Linard Hoessly

We present a framework for differentiable quantum transforms. Such transforms are metaprograms capable of manipulating quantum programs in a way that preserves their differentiability. We highlight their potential with a set of relevant…

Cognitive radio networks (CRNs) are networks of nodes equipped with cognitive radios that can optimize performance by adapting to network conditions. While cognitive radio networks (CRN) are envisioned as intelligent networks, relatively…

Networking and Internet Architecture · Computer Science 2015-11-06 Junaid Qadir

Simulations of complex physical systems are typically realized by discretizing partial differential equations (PDEs) on unstructured meshes. While neural networks have recently been explored for surrogate and reduced order modeling of PDE…

Machine Learning · Computer Science 2021-10-27 Jiayang Xu , Aniruddhe Pradhan , Karthik Duraisamy

This paper presents a unified mixed-integer programming framework for training sparse and interpretable neural networks. We develop exact formulations for both fully connected and convolutional architectures by modeling nonlinearities such…

Artificial Intelligence · Computer Science 2025-04-22 Masoud Ataei , Edrin Hasaj , Jacob Gipp , Sepideh Forouzi

Neural network pruning is a key technique towards engineering large yet scalable, interpretable, and generalizable models. Prior work on the subject has developed largely along two orthogonal directions: (1) differentiable pruning for…

Machine Learning · Computer Science 2025-02-12 Taisuke Yasuda , Kyriakos Axiotis , Gang Fu , MohammadHossein Bateni , Vahab Mirrokni

This paper investigates efficient deep neural networks (DNNs) to replace dense unstructured weight matrices with structured ones that possess desired properties. The challenge arises because the optimal weight matrix structure in popular…

Machine Learning · Computer Science 2024-03-11 Changwoo Lee , Hun-Seok Kim

Chemically reacting flows are common in engineering, such as hypersonic flow, combustion, explosions, manufacturing processes and environmental assessments. For combustion, the number of reactions can be significant (over 100) and due to…

Machine Learning · Computer Science 2021-04-06 Thomas S. Brown , Harbir Antil , Rainald Löhner , Fumiya Togashi , Deepanshu Verma

Machine learning methods have found many applications in Raman spectroscopy, especially for the identification of chemical species. However, almost all of these methods require non-trivial preprocessing such as baseline correction and/or…

Machine Learning · Computer Science 2018-02-07 Jinchao Liu , Margarita Osadchy , Lorna Ashton , Michael Foster , Christopher J. Solomon , Stuart J. Gibson

In the field of molecular computation based on chemical reaction networks (CRNs), leveraging parallelism to enable coupled mass-action systems (MASs) to retain predefined computational functionality has been a research focus. MASs…

Dynamical Systems · Mathematics 2025-10-16 Renlei Jiang , Chuanhou Gao , Denis Dochain

Many biological systems can be modeled as a chemical reaction network with unknown parameters. Data available to identify these parameters are often in the form of a stationary distribution, such as that obtained from measurements of a cell…

Systems and Control · Electrical Eng. & Systems 2023-09-14 Theodore W. Grunberg , Domitilla Del Vecchio

Artificial intelligence has recently experienced remarkable advances, fueled by large models, vast datasets, accelerated hardware, and, last but not least, the transformative power of differentiable programming. This new programming…

Machine Learning · Computer Science 2025-06-25 Mathieu Blondel , Vincent Roulet

Chemical reaction networks (CRNs) exhibit complex dynamics governed by their underlying network structure. In this paper, we propose a novel approach to study the dynamics of CRNs by representing them on species graphs (S-graphs). By…

Molecular Networks · Quantitative Biology 2024-04-24 Keisuke Sugie , Dimitri Loutchko , Tetsuya J. Kobayashi

Ordinary differential equations are widely-used in the field of systems biology and chemical engineering to model chemical reaction networks. Numerous techniques have been developed to estimate parameters like rate constants, initial…

Molecular Networks · Quantitative Biology 2012-07-06 Daniel Kaschek , Jens Timmer

Solving for detailed chemical kinetics remains one of the major bottlenecks for computational fluid dynamics simulations of reacting flows using a finite-rate-chemistry approach. This has motivated the use of fully connected artificial…

Computational Engineering, Finance, and Science · Computer Science 2021-10-11 Opeoluwa Owoyele , Pinaki Pal

Exploring large chemical reaction networks with automated exploration approaches and accurate quantum chemical methods can require prohibitively large computational resources. Here, we present an automated exploration approach that focuses…

Chemical Physics · Physics 2024-06-12 Moritz Bensberg , Markus Reiher

Deterministic reaction networks (RNs) are tools to model diverse biological phenomena characterized by particle systems, when there are abundant number of particles. Examples include but are not limited to biochemistry, molecular biology,…

Molecular Networks · Quantitative Biology 2021-07-22 Carsten Wiuf , Chuang Xu

The differentiable programming paradigm is a cornerstone of modern scientific computing. It refers to numerical methods for computing the gradient of a numerical model's output. Many scientific models are based on differential equations,…

Deep neural networks (DNNs) have shown remarkable performance improvements on vision-related tasks such as object detection or image segmentation. Despite their success, they generally lack the understanding of 3D objects which form the…

Computer Vision and Pattern Recognition · Computer Science 2020-08-03 Hiroharu Kato , Deniz Beker , Mihai Morariu , Takahiro Ando , Toru Matsuoka , Wadim Kehl , Adrien Gaidon