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Artificial intelligence (AI) systems utilizing deep neural networks (DNNs) and machine learning (ML) algorithms are widely used for solving important problems in bioinformatics, biomedical informatics, and precision medicine. However,…

Quantitative Methods · Quantitative Biology 2023-02-24 Md. Rezaul Karim , Tanhim Islam , Oya Beyan , Christoph Lange , Michael Cochez , Dietrich Rebholz-Schuhmann , Stefan Decker

Explainable Artificial Intelligence (XAI) has emerged as a pillar of Trustworthy AI and aims to bring transparency in complex models that are opaque by nature. Despite the benefits of incorporating explanations in models, an urgent need is…

Artificial Intelligence · Computer Science 2025-12-04 Sonal Allana , Mohan Kankanhalli , Rozita Dara

Explainable AI (XAI) is widely used to analyze AI systems' decision-making, such as providing counterfactual explanations for recourse. When unexpected explanations occur, users may want to understand the training data properties shaping…

Machine Learning · Computer Science 2025-03-26 André Artelt , Barbara Hammer

As the adoption of explainable AI (XAI) continues to expand, the urgency to address its privacy implications intensifies. Despite a growing corpus of research in AI privacy and explainability, there is little attention on privacy-preserving…

Cryptography and Security · Computer Science 2024-06-27 Thanh Tam Nguyen , Thanh Trung Huynh , Zhao Ren , Thanh Toan Nguyen , Phi Le Nguyen , Hongzhi Yin , Quoc Viet Hung Nguyen

Explainable machine learning (ML) enables human learning from ML, human appeal of automated model decisions, regulatory compliance, and security audits of ML models. Explainable ML (i.e. explainable artificial intelligence or XAI) has been…

Machine Learning · Statistics 2019-12-03 Patrick Hall , Navdeep Gill , Nicholas Schmidt

Last years have been characterized by an upsurge of opaque automatic decision support systems, such as Deep Neural Networks (DNNs). Although they have great generalization and prediction skills, their functioning does not allow obtaining…

Nowadays, deep neural networks are widely used in mission critical systems such as healthcare, self-driving vehicles, and military which have direct impact on human lives. However, the black-box nature of deep neural networks challenges its…

Computer Vision and Pattern Recognition · Computer Science 2020-06-24 Arun Das , Paul Rad

There are concerns about the reliability and safety of artificial intelligence (AI) based on sub-symbolic neural networks because its decisions cannot be explained explicitly. This is the black box problem of modern AI. At the same time,…

Artificial Intelligence · Computer Science 2024-05-21 V. L. Kalmykov , L. V. Kalmykov

In the past few years, artificial intelligence (AI) techniques have been implemented in almost all verticals of human life. However, the results generated from the AI models often lag explainability. AI models often appear as a blackbox…

Given the sheer volume of surgical procedures and the significant rate of postoperative fatalities, assessing and managing surgical complications has become a critical public health concern. Existing artificial intelligence (AI) tools for…

Language Models (LMs) have significantly advanced natural language processing and enabled remarkable progress across diverse domains, yet their black-box nature raises critical concerns about the interpretability of their internal…

Computation and Language · Computer Science 2025-09-29 Avash Palikhe , Zichong Wang , Zhipeng Yin , Rui Guo , Qiang Duan , Jie Yang , Wenbin Zhang

Explainable AI (XAI) techniques are necessary to help clinicians make sense of AI predictions and integrate predictions into their decision-making workflow. In this work, we conduct a survey study to understand clinician preference among…

Computation and Language · Computer Science 2025-08-28 Jun Hou , Lucy Lu Wang

The field of "explainable artificial intelligence" (XAI) seemingly addresses the desire that decisions of machine learning systems should be human-understandable. However, in its current state, XAI itself needs scrutiny. Popular methods…

Machine Learning · Computer Science 2026-04-09 Stefan Haufe , Rick Wilming , Benedict Clark , Rustam Zhumagambetov , Ahcène Boubekki , Jörg Martin , Danny Panknin

Recent work has investigated the concept of adversarial attacks on explainable AI (XAI) in the NLP domain with a focus on examining the vulnerability of local surrogate methods such as Lime to adversarial perturbations or small changes on…

Machine Learning · Computer Science 2025-01-07 Christopher Burger , Charles Walter , Thai Le , Lingwei Chen

XAI refers to the techniques and methods for building AI applications which assist end users to interpret output and predictions of AI models. Black box AI applications in high-stakes decision-making situations, such as medical domain have…

Given the complexity and lack of transparency in deep neural networks (DNNs), extensive efforts have been made to make these systems more interpretable or explain their behaviors in accessible terms. Unlike most reviews, which focus on…

Artificial Intelligence · Computer Science 2024-01-17 Haoyi Xiong , Xuhong Li , Xiaofei Zhang , Jiamin Chen , Xinhao Sun , Yuchen Li , Zeyi Sun , Mengnan Du

Recent developments in Artificial Intelligence (AI) and their applications in critical industries such as healthcare, fin-tech and cybersecurity have led to a surge in research in explainability in AI. Innovative research methods are being…

Artificial Intelligence · Computer Science 2025-08-26 Aoun E Muhammad , Kin-Choong Yow , Nebojsa Bacanin-Dzakula , Muhammad Attique Khan

Explainable AI (XAI) aims to improve user understanding and decisions when using AI models. However, despite innovations in XAI, recent user evaluations reveal that this goal remains elusive. Understanding human cognition can help explain…

Artificial Intelligence · Computer Science 2026-05-01 Louth Bin Rawshan , Zhuoyu Wang , Brian Y. Lim

Explainable Artificial Intelligence (XAI) plays a crucial role in fostering transparency and trust in AI systems, where traditional XAI approaches typically offer one level of abstraction for explanations, often in the form of heatmaps…

Complex systems are increasingly explored through simulation-driven engineering workflows that combine physics-based and empirical models with optimization and analytics. Despite their power, these workflows face two central obstacles: (1)…