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This paper presents an approach to estimating the health effects of an environmental hazard. The approach is general in nature, but is applied here to the case of air pollution. It uses a computer model involving ambient pollution and…

Applications · Statistics 2007-11-01 Gavin Shaddick , Duncan Lee , James V. Zidek , Ruth Salway

The health effects of environmental exposures have been studied for decades, typically using standard regression models to assess exposure-outcome associations found in observational non-experimental data. We propose and illustrate a…

Applications · Statistics 2017-09-20 Marie-Abele C. Bind , Donald B. Rubin

A wealth of epidemiological data suggests an association between mortality/morbidity from pulmonary and cardiovascular adverse events and air pollution, but uncertainty remains as to the extent implied by those associations although the…

Applications · Statistics 2008-06-16 Massimo Bilancia , Girolamo Stea

We develop new methodology to improve our understanding of the causal effects of multivariate air pollution exposures on public health. Typically, exposure to air pollution for an individual is measured at their home geographic region,…

Methodology · Statistics 2025-11-18 Heejun Shin , Danielle Braun , Kezia Irene , Michelle Audirac , Joseph Antonelli

This paper introduces a novel spatial scalar-on-function quantile regression model that extends classical scalar-on-function models to account for spatial dependence and heterogeneous conditional distributions. The proposed model…

Methodology · Statistics 2025-10-21 Muge Mutis , Ufuk Beyaztas , Filiz Karaman , Han Lin Shang

Recent studies of associations between environmental exposures and health outcomes have shifted toward estimating the effect of simultaneous exposure to multiple chemicals. Summary index methods, such as the weighted quantile sum and…

Applications · Statistics 2025-02-21 Jacob Englert , Howard Chang

Estimating the joint effect of a multivariate, continuous exposure is crucial, particularly in environmental health where interest lies in simultaneously evaluating the impact of multiple environmental pollutants on health. We develop novel…

Laboratory experiments have shown that cardiovascular diseases are positively correlated to the concentration of ambient air pollutants, such as SO2, NO2, PM10, etc. It has also been repeatedly reported in many countries that increased…

Applications · Statistics 2013-08-08 Menghui Li , Dasheng Luo , Chenghua Cao , Xiaochuan Pan , Qixin Wang

When exposure measurement error (EME), confounder measurement error (CME), or both are present, health effect estimates regarding exposure mixtures and critical exposure time-window may not represent the true effects. For example, in air…

Statistics Theory · Mathematics 2025-05-28 Honghyok Kim

The Clean Air Act mandates that the National Ambient Air Quality Standards (NAAQS) must be routinely assessed to protect populations based on the latest science. Therefore, researchers should continue to address whether exposure to levels…

Methodology · Statistics 2020-01-09 Georgia Papadogeorgou , Francesca Dominici

We develop new matching estimators for estimating causal quantile exposure-response functions and quantile exposure effects with continuous treatments. We provide identification results for the parameters of interest and establish the…

Methodology · Statistics 2023-08-04 Luca Merlo , Francesca Dominici , Lea Petrella , Nicola Salvati , Xiao Wu

Environmental epidemiologists are often interested in estimating the effect of time-varying functions of the exposure history on health outcomes. However, the individual exposure measurements that constitute the history upon which an…

Methodology · Statistics 2025-05-23 Ce Yang , Ning Zhang , Jiaxuan Li , Unnati V. Mehta , Jaime E. Hart , Donna Spiegelman , Molin Wang

The relationship between short-term exposure to air pollution and mortality or morbidity has been the subject of much recent research, in which the standard method of analysis uses Poisson linear or additive models. In this paper we use a…

Applications · Statistics 2012-01-27 Duncan Lee , Gavin Shaddick

The health impact of long-term exposure to air pollution is now routinely estimated using spatial ecological studies, due to the recent widespread availability of spatial referenced pollution and disease data. However, this areal unit study…

Applications · Statistics 2014-12-16 Duncan Lee , Christophe Sarran

Estimation of the long-term health effects of air pollution is a challenging task, especially when modelling small-area disease incidence data in an ecological study design. The challenge comes from the unobserved underlying spatial…

Methodology · Statistics 2013-05-24 Duncan Lee , Alastair Rushworth , Sujit K. Sahu

Motivated by analyzing a national data base of annual air pollution and cardiovascular disease mortality rate for 3100 counties in the U.S. (areal data), we develop a novel statistical framework to automatically detect spatially varying…

Applications · Statistics 2015-11-19 Shuo Chen , Chengsheng Jiang , Lance Waller

Evaluating the causal health effects of multivariate, continuous exposures, such as air pollution mixtures, is a critical public health challenge. A primary obstacle is the frequent violation of the positivity assumption, which renders the…

Methodology · Statistics 2026-05-05 Zhuochao Huang , Kejin Dong , Tuo Lin , Joseph Antonelli

Air pollution is a pressing environmental risk to public health, particularly in cities where population density and pollution levels are high. Traditional methods for exposure analysis often rely on census data, but recent studies…

Quantifying associations between short-term exposure to ambient air pollution and health outcomes is an important public health priority. Many studies have investigated the association considering delayed effects within the past few days.…

Methodology · Statistics 2025-05-22 Tianyi Pan , Hwashin Hyun Shin , Glen McGee , Alex Stringer

A typical problem in air pollution epidemiology is exposure assessment for individuals for which health data are available. Due to the sparsity of monitoring sites and the limited temporal frequency with which measurements of air pollutants…

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