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Objective: The Mapper algorithm is a qualitative method in topological data analysis that constructs graphs from point clouds by combining dimensionality reduction and clustering techniques. The aim of this study is to apply Mapper,…

Quantitative Methods · Quantitative Biology 2026-04-22 Aina Ferrà Marcús , Carles Casacuberta , Josep Vives , Joan Guich , Gerard Amorós-Figueras , Jose M. Guerra

Modeling temporal changes in subcortical structures is crucial for a better understanding of the progression of Alzheimer's disease (AD). Given their flexibility to adapt to heterogeneous sequence lengths, mesh-based transformer…

Computer Vision and Pattern Recognition · Computer Science 2022-07-06 Ignacio Sarasua , Sebastian Pölsterl , Christian Wachinger

Introduction: It is challenging at baseline to predict when and which individuals who meet criteria for mild cognitive impairment (MCI) will ultimately progress to Alzheimer's disease (AD) dementia. Methods: A deep learning method is…

Computer Vision and Pattern Recognition · Computer Science 2019-04-17 Hongming Li , Mohamad Habes , David A. Wolk , Yong Fan

In this study, we propose a novel method to measure bottom-up saliency maps of natural images. In order to eliminate the influence of top-down signals, backward masking is used to make stimuli (natural images) subjectively invisible to…

Computer Vision and Pattern Recognition · Computer Science 2016-04-30 Cheng Chen , Xilin Zhang , Yizhou Wang , Fang Fang

Methods: Our deep learning model, called AnatomyNet, segments OARs from head and neck CT images in an end-to-end fashion, receiving whole-volume HaN CT images as input and generating masks of all OARs of interest in one shot. AnatomyNet is…

Computer Vision and Pattern Recognition · Computer Science 2019-03-06 Wentao Zhu , Yufang Huang , Liang Zeng , Xuming Chen , Yong Liu , Zhen Qian , Nan Du , Wei Fan , Xiaohui Xie

Mammalian hippocampus plays a key role in spatial learning and memory, but the exact nature of the hippocampal representation of space is still being explored. Recently, there has been a fair amount of success in modeling hippocampal…

Neurons and Cognition · Quantitative Biology 2016-01-19 Kentaro Hoffman , Andrey Babichev , Yuri Dabaghian

Cell image analysis is crucial in Alzheimer's research to detect the presence of A$\beta$ protein inhibiting cell function. Deep learning speeds up the process by making only low-level data sufficient for fruitful inspection. We first found…

Image and Video Processing · Electrical Eng. & Systems 2021-08-04 Wooseok Jung

Prediction of the cognitive evolution of a person susceptible to develop a neurodegenerative disorder is crucial to provide an appropriate treatment as soon as possible. In this paper we propose a 3D siamese network designed to extract…

Image and Video Processing · Electrical Eng. & Systems 2019-09-04 Cecilia Ostertag , Marie Beurton-Aimar , Thierry Urruty

The improvements in magnetic resonance imaging have led to the development of numerous techniques to better detect structural alterations caused by neurodegenerative diseases. Among these, the patch-based grading framework has been proposed…

Image and Video Processing · Electrical Eng. & Systems 2020-01-24 Kilian Hett , Hans Johnson , Pierrick Coupé , Jane Paulsen , Jeffrey Long , Ipek Oguz

Human brain connectome studies aim at extracting and analyzing relevant features associated to pathologies of interest. Usually this consists in modeling the brain connectome as a graph and in using graph metrics as features. A fine brain…

Neurons and Cognition · Quantitative Biology 2020-05-04 Félix Renard , Christian Heinrich , Marine Bouthillon , Maleka Schenck , Francis Schneider , Stéphane Kremer , Sophie Achard

Accurate hippocampus segmentation in brain MRI is critical for studying cognitive and memory functions and diagnosing neurodevelopmental disorders. While high-field MRIs provide detailed imaging, low-field MRIs are more accessible and…

Image and Video Processing · Electrical Eng. & Systems 2024-10-24 Himashi Peiris , Zhaolin Chen

Quantitative susceptibility mapping (QSM) estimates the underlying tissue magnetic susceptibility from MRI gradient-echo phase signal and typically requires several processing steps. These steps involve phase unwrapping, brain volume…

Image and Video Processing · Electrical Eng. & Systems 2019-05-16 Hongjiang Wei , Steven Cao , Yuyao Zhang , Xiaojun Guan , Fuhua Yan , Kristen W. Yeom , Chunlei Liu

In this paper we introduce a novel method to estimate the head pose of people in single images starting from a small set of head keypoints. To this purpose, we propose a regression model that exploits keypoints computed automatically by 2D…

Computer Vision and Pattern Recognition · Computer Science 2021-11-04 Giorgio Cantarini , Federico Figari Tomenotti , Nicoletta Noceti , Francesca Odone

The aging society urgently requires scalable methods to monitor cognitive decline and identify social and psychological factors indicative of dementia risk in older adults. Our machine learning (ML) models captured facial, acoustic,…

This study presents an innovative method for Alzheimer's disease diagnosis using 3D MRI designed to enhance the explainability of model decisions. Our approach adopts a soft attention mechanism, enabling 2D CNNs to extract volumetric…

Image and Video Processing · Electrical Eng. & Systems 2024-10-02 Gabriele Lozupone , Alessandro Bria , Francesco Fontanella , Frederick J. A. Meijer , Claudio De Stefano

We employ the Hopfield model as a simplified framework to explore both the memory deficits and the biochemical processes characteristic of Alzheimer's disease. By simulating neuronal death and synaptic degradation through increasing the…

Neurons and Cognition · Quantitative Biology 2024-10-11 Sai Nag Anurag Nangunoori , Akshara Karthic Mahadevan

It is challenging to directly estimate the human geometry from a single image due to the high diversity and complexity of body shapes with the various clothing styles. Most of model-based approaches are limited to predict the shape and pose…

Computer Vision and Pattern Recognition · Computer Science 2022-02-02 Lixiang Lin , Jianke Zhu

We recently published a deep learning study on the potential of encoder-decoder networks for the segmentation of the 2D CAMUS ultrasound dataset. We propose in this abstract an extension of the evaluation criteria to anatomical assessment,…

Automated diagnosis of Alzheimer Disease(AD) from brain imaging, such as magnetic resonance imaging (MRI), has become increasingly important and has attracted the community to contribute many deep learning methods. However, many of these…

Image and Video Processing · Electrical Eng. & Systems 2024-03-01 Yifeng Wang , Ke Chen , Haohan Wang

Longitudinal biomedical studies monitor individuals over time to capture dynamics in brain development, disease progression, and treatment effects. However, estimating trajectories of brain biomarkers is challenging due to biological…

Machine Learning · Computer Science 2025-04-15 Vasiliki Tassopoulou , Haochang Shou , Christos Davatzikos