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DNA sequence analysis is fundamental to life science research. The rapid development of next generation sequencing (NGS) technologies, and the richness and diversity of applications it makes feasible, have created an enormous gulf between…

Computational Engineering, Finance, and Science · Computer Science 2013-10-29 Shel Swenson , Yogesh Simmhan , Viktor Prasanna , Manish Parashar , Jason Riedy , David Bader , Richard Vuduc

Several papers have recently contained reports on applying machine learning (ML) to the automation of software engineering (SE) tasks, such as project management, modeling and development. However, there appear to be no approaches comparing…

Software Engineering · Computer Science 2018-02-09 Nathalia Nascimento , Carlos Lucena , Paulo Alencar , Donald Cowan

For more than 30 years, it has been claimed that a way to improve software developers' productivity and software quality is to focus on people and to provide incentives to make developers satisfied and happy. This claim has rarely been…

Software Engineering · Computer Science 2015-05-06 Daniel Graziotin , Xiaofeng Wang , Pekka Abrahamsson

While the methodological rigor of computing research has improved considerably in the past two decades, quantitative software engineering research is hampered by immature measures and inattention to theory. Measurement-the principled…

Software Engineering · Computer Science 2024-06-21 Paul Ralph , Miikka Kuutila , Hera Arif , Bimpe Ayoola

Statistics experiences a storm around the perceived misuse and possible abuse of its methods in the context of the so-called reproducibility crisis. The methods and styles of quantification practiced in mathematical modelling rarely make it…

Methodology · Statistics 2019-08-20 Andrea Saltelli

According to psychology, not everybody can excel at all kinds of tasks. Thus, chances of a successful outcome of software development increase if people with particular personality types are assigned to their preferred tasks in the project.…

Computers and Society · Computer Science 2015-11-16 Luiz Fernando Capretz , Daniel Varona , Arif Raza

The software is often produced under significant time constraints. Our idea is to understand the effects of various software development practices on the performance of developers working in stressful environments, and identify the best…

Software Engineering · Computer Science 2018-04-25 Joseph Alexander Brown , Vladimir Ivanov , Alan Rogers , Giancarlo Succi , Alexander Tormasov , Jooyong Yi

Scientific open-source software (Sci-OSS) projects are critical for advancing research, yet sustaining these projects long-term remains a major challenge. This paper explores the sustainability of Sci-OSS hosted on GitHub, focusing on two…

Software Engineering · Computer Science 2025-11-12 Sharif Ahmed , Addi Malviya Thakur , Gregory R. Watson , Nasir U. Eisty

Increasingly sophisticated experiments, coupled with large-scale computational models, have the potential to systematically test biological hypotheses to drive our understanding of multicellular systems. In this short review, we explore key…

Quantitative Methods · Quantitative Biology 2019-10-28 Paul Macklin

The advancement of software sustainability encounters notable challenges, underscoring the necessity for understanding these challenges to facilitate significant progress and pave the way for effective solutions to advance software…

Software Engineering · Computer Science 2024-05-27 Jennifer Gross , Sofia Ouhbi

Systems biology models are useful models of complex biological systems that may require a large amount of experimental data to fit each model's parameters or to approximate a likelihood function. These models range from a few to thousands…

Quantitative Methods · Quantitative Biology 2024-07-12 Vincent D. Zaballa , Elliot E. Hui

Applications integrating analysis components require a programmable interface which defines statistical operations independently of any programming language. By separating concerns of scientific computing from application and implementation…

Computation · Statistics 2014-06-19 Jeroen Ooms

Motivation: Bioinformatics is faced with a variety of problems that require human involvement. Tasks like genome annotation, image analysis, knowledge-base construction and protein structure determination all benefit from human input. In…

Quantitative Methods · Quantitative Biology 2013-07-01 Benjamin M. Good , Andrew I. Su

Over the recent years the importance of numerical experiments has gradually been more recognized. Nonetheless, sufficient documentation of how computational results have been obtained is often not available. Especially in the scientific…

Mathematical Software · Computer Science 2021-05-10 Jörg Fehr , Jan Heiland , Christian Himpe , Jens Saak

Context: Scientific open-source software (SciOSS) plays a foundational role in research and engineering, yet its long-term sustainability has often been overlooked and remains a significant concern. Objective: This study investigates the…

Software Engineering · Computer Science 2026-05-06 Sheikh Md. Mushfiqur Rahman , Gregory R. Watson , Nasir U. Eisty

Scientists across disciplines write code for critical activities like data collection and generation, statistical modeling, and visualization. As large language models that can generate code have become widely available, scientists may…

Software Engineering · Computer Science 2025-02-25 Gabrielle O'Brien

Bayesian optimization has become widely popular across various experimental sciences due to its favorable attributes: it can handle noisy data, perform well with relatively small datasets, and provide adaptive suggestions for sequential…

Other Quantitative Biology · Quantitative Biology 2025-08-15 Maximilian Siska , Emma Pajak , Katrin Rosenthal , Antonio del Rio Chanona , Eric von Lieres , Laura Marie Helleckes

This paper presents a student-led activity designed to explore the use of statistical software in academic research across economics, political science, and statistics. Students reviewed replication files from major journals and…

Other Statistics · Statistics 2025-04-10 Elizabeth Upton , Xizhen Cai , Pamela Jakiela , Owen Ozier , Shyam Raman

Open science describes the movement of making any research artefact available to the public and includes, but is not limited to, open access, open data, and open source. While open science is becoming generally accepted as a norm in other…

Software Engineering · Computer Science 2021-02-10 Daniel Méndez Fernández , Daniel Graziotin , Stefan Wagner , Heidi Seibold

Context. Women remain significantly underrepresented in software engineering, leading to a lasting gender gap in the software industry. This disparity starts in education and extends into the industry, causing challenges such as hostile…

Software Engineering · Computer Science 2023-12-11 Tatalina Oliveira , Ann Barcomb , Ronnie de Souza Santos , Helda Barros , Maria Teresa Baldassarre , César França