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Conformation generation, also known as molecular unfolding (MU), is a crucial step in structure-based drug design, remaining a challenging combinatorial optimization problem. Quantum annealing (QA) has shown great potential for solving…

Resource allocation of wide-area internet networks is inherently a combinatorial optimization problem that if solved quickly, could provide near real-time adaptive control of internet-protocol traffic ensuring increased network efficacy and…

Quantum Physics · Physics 2024-05-21 Arthur Witt , Jangho Kim , Christopher Körber , Thomas Luu

Using a specially constructed set of hard 2-SAT problems with four satisfying assignments, we study the scaling and sampling performance of numerical simulation of quantum annealing as well as that of the physical quantum annealers offered…

Quantum Physics · Physics 2025-11-04 Vrinda Mehta , Hans De Raedt , Kristel Michielsen , Fengping Jin

Quantum annealing is a new method for finding extrema of multidimensional functions. Based on an extension of classical, simulated annealing, this approach appears robust with respect to avoiding local minima. Further, unlike some of its…

chem-ph · Physics 2009-10-22 A. B. Finnila , M. A. Gomez , C. Sebenik , C. Stenson , J. D. Doll

Quantum Annealing (QA) is one of the most promising frameworks for quantum optimization. Here, we focus on the problem of minimizing complex classical cost functions associated with prototypical discrete neural networks, specifically the…

Quantum Physics · Physics 2023-05-17 Guglielmo Lami , Pietro Torta , Giuseppe E. Santoro , Mario Collura

Database systems encompass several performance-critical optimization tasks, such as join ordering and index tuning. As data volumes grow and workloads become more complex, these problems have become exponentially harder to solve…

Databases · Computer Science 2026-01-21 Hanwen Liu , Ibrahim Sabek

With progress in quantum technology more sophisticated quantum annealing devices are becoming available. While they offer new possibilities for solving optimization problems, their true potential is still an open question. As the optimal…

Quantum Physics · Physics 2017-02-22 Bettina Heim , Ethan W. Brown , Dave Wecker , Matthias Troyer

Over the past decade, the usefulness of quantum annealing hardware for combinatorial optimization has been the subject of much debate. Thus far, experimental benchmarking studies have indicated that quantum annealing hardware does not…

Optimization and Control · Mathematics 2022-10-11 Byron Tasseff , Tameem Albash , Zachary Morrell , Marc Vuffray , Andrey Y. Lokhov , Sidhant Misra , Carleton Coffrin

Recent demonstrations on specialized benchmarks have reignited excitement for quantum computers, yet whether they can deliver an advantage for practical real-world problems remains an open question. Here, we show that probabilistic…

The Minimum Bisection Problem is a well-known NP-hard problem in combinatorial optimization, with practical applications in areas such as parallel computing, network design, and machine learning. In this paper, we examine the potential of…

Quantum Physics · Physics 2025-09-24 Renáta Rusnáková , Martin Chovanec , Juraj Gazda

Topological quantum computing has recently proven itself to be a powerful computational model when constructing viable architectures for large scale computation. The topological model is constructed from the foundation of a error correction…

Quantum Physics · Physics 2013-06-24 Simon J. Devitt , Kae Nemoto

Recent advances bring within reach the viability of solving combinatorial problems using a quantum annealing algorithm implemented on a purpose-built platform that exploits quantum properties. However, the question of how to tune the…

Data Structures and Algorithms · Computer Science 2014-10-21 Andrew D. King , Catherine C. McGeoch

Quantum annealing devices such as the ones produced by D-Wave systems are typically used for solving optimization and sampling tasks, and in both academia and industry the characterization of their usefulness is subject to active research.…

We introduce an optimisation method for variational quantum algorithms and experimentally demonstrate a 100-fold improvement in efficiency compared to naive implementations. The effectiveness of our approach is shown by obtaining…

Sampling a diverse set of high-quality solutions for hard optimization problems is of great practical relevance in many scientific disciplines and applications, such as artificial intelligence and operations research. One of the main open…

Quantum computing (QC) has gained popularity due to its unique capabilities that are quite different from that of classical computers in terms of speed and methods of operations. This paper proposes hybrid models and methods that…

Quantum Physics · Physics 2019-11-12 Akshay Ajagekar , Travis Humble , Fengqi You

The Closest String Problem is an NP-complete problem which appears more commonly in bioinformatics and coding theory. Less surprisingly, classical approaches have been pursued with two prominent algorithms being the genetic algorithm and…

Quantum Physics · Physics 2023-10-20 Chandeepa Dissanayake

Mixed discrete-continuous optimization is central to engineering design, where discrete choices interact with continuous fields. These problems are difficult due to high-dimensional, complex search spaces. To tackle them, Quantum Annealing…

Computational Engineering, Finance, and Science · Computer Science 2026-03-19 Fabian Key , Lukas Freinberger , Mayu Muramatsu , Norbert Hosters

A variational framework for structural topology optimization is developed, integrating quantum and classical latent encoding strategies within a coordinate-based neural decoding architecture. In this approach, a low-dimensional latent…

Computational Engineering, Finance, and Science · Computer Science 2025-06-24 Alireza Tabarraei

In this work, we develop a new quantum algorithm to solve a combinatorial problem with significant practical relevance occurring in clutch manufacturing. It is demonstrated how quantum optimization can play a role in real industrial…