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Topological data analysis (TDA) is a rapidly evolving field in applied mathematics and data science that leverages tools from topology to uncover robust, shape-driven insights in complex datasets. The main workhorse is persistent homology,…

History and Overview · Mathematics 2025-07-29 Zhe Su , Xiang Liu , Layal Bou Hamdan , Vasileios Maroulas , Jie Wu , Gunnar Carlsson , Guo-Wei Wei

Persistent topological Laplacians constitute a new class of tools in topological data analysis (TDA). They are motivated by the necessity to address challenges encountered in persistent homology when handling complex data. These Laplacians…

Algebraic Topology · Mathematics 2024-12-12 Xiaoqi Wei , Guo-Wei Wei

Topological data analysis (TDA) has had enormous success in science and engineering in the past decade. Persistent topological Laplacians (PTLs) overcome some limitations of persistent homology, a key technique in TDA, and provide…

Algebraic Topology · Mathematics 2023-12-05 Benjamin Jones , Guowei Wei

Topological Data Analysis (TDA) has emerged as a powerful framework for extracting robust, multiscale, and interpretable features from complex molecular data for artificial intelligence (AI) modeling and topological deep learning (TDL).…

Biomolecules · Quantitative Biology 2025-09-23 JunJie Wee , Jian Jiang

Topological methods can provide a way of proposing new metrics and methods of scrutinising data, that otherwise may be overlooked. In this work, a method of quantifying the shape of data, via a topic called topological data analysis will be…

Machine Learning · Statistics 2022-09-25 Tristan Gowdridge , Nikolaos Dervilis , Keith Worden

Topological Data Analysis (TDA) is a novel statistical technique, particularly powerful for the analysis of large and high dimensional data sets. Much of TDA is based on the tool of persistent homology, represented visually via persistence…

Applications · Statistics 2017-11-07 Sarit Agami , Robert J. Adler

Algebraic topology has been widely applied to point cloud data to capture geometric shapes and topological structures. However, its application to genome sequence analysis remains rare. In this work, we propose topological sequence analysis…

Algebraic Topology · Mathematics 2025-07-09 Jian Liu , Li Shen , Dong Chen , Guo-Wei Wei

Topological Data Analysis (TDA) is a rising field of computational topology in which the topological structure of a data set can be observed by persistent homology. By considering a sequence of sublevel sets, one obtains a filtration that…

Methodology · Statistics 2020-03-17 Yu-Min Chung , William Cruse , Austin Lawson

The fast evolution of SARS-CoV-2 and other infectious viruses poses a grand challenge to the rapid response in terms of viral tracking, diagnostics, and design and manufacture of monoclonal antibodies (mAbs) and vaccines, which are both…

Biomolecules · Quantitative Biology 2024-11-20 JunJie Wee , Guo-Wei Wei

Persistent homology is a widely-used tool in topological data analysis (TDA) for understanding the underlying shape of complex data. By constructing a filtration of simplicial complexes from data points, it captures topological features…

Algebraic Topology · Mathematics 2025-10-23 Aleksei Luchinsky , Umar Islambekov

Topological Data Analysis (TDA) is a novel, and relatively new approach to analysing high-dimensional data sets. It does this by focussing on global properties like the shape and connectivity of the data giving it a significant advantage…

Instrumentation and Methods for Astrophysics · Physics 2019-04-26 Jeff Murugan , Duncan Robertson

Interacting, self-propelled particles such as epithelial cells can dynamically self-organize into complex multicellular patterns, which are challenging to classify without a priori information. Classically, different phases and phase…

Quantitative Methods · Quantitative Biology 2021-01-19 Dhananjay Bhaskar , William Y. Zhang , Ian Y. Wong

Accurate prediction of protein-ligand binding affinity remains a central challenge in structure-based drug discovery. The effectiveness of machine learning models critically depends on the quality of molecular descriptors, for which…

Biomolecules · Quantitative Biology 2026-03-24 Jian Liu , Hongsong Feng

Topological data analysis (TDA) is a rising branch in modern applied mathematics. It extracts topological structures as features of a given space and uses these features to analyze digital data. Persistent homology, one of the central tools…

Algebraic Topology · Mathematics 2025-05-26 Chuan-Shen Hu

Topological Data Analysis (TDA) offers a suite of computational tools that provide quantified shape features in high dimensional data that can be used by modern statistical and predictive machine learning (ML) models. In particular,…

Cryptography and Security · Computer Science 2023-07-06 Dominic Gold , Koray Karabina , Francis C. Motta

Recent years have witnessed a fast growth in mathematical artificial intelligence (AI). One of the most successful mathematical AI approaches is topological data analysis (TDA) via persistent homology (PH) that provides explainable AI (xAI)…

General Topology · Mathematics 2025-10-27 Yiming Ren , Guowei Wei

Topological Data Analysis (TDA) is a field that leverages tools and ideas from algebraic topology to provide robust methods for analysing geometric and topological aspects of data. One of the principal tools of TDA, persistent homology,…

High Energy Physics - Lattice · Physics 2023-02-16 Nicholas Sale , Biagio Lucini , Jeffrey Giansiracusa

Recent advances in topology-based modeling have accelerated progress in physical modeling and molecular studies, including applications to protein-ligand binding affinity. In this work, we introduce the Persistent Laplacian Decision Tree…

Biomolecules · Quantitative Biology 2024-12-25 Xingjian Xu , Jiahui Chen , Chunmei Wang

Recently, topological data analysis has become a trending topic in data science and engineering. However, the key technique of topological data analysis, i.e., persistent homology, is defined on point cloud data, which does not work…

Differential Geometry · Mathematics 2024-11-08 Zhe Su , Yiying Tong , Guo-Wei Wei

Genetic mutations frequently disrupt protein structure, stability, and solubility, acting as primary drivers for a wide spectrum of diseases. Despite the critical importance of these molecular alterations, existing computational models…

Spectral Theory · Mathematics 2026-01-21 Yiming Ren , Junjie Wee , Xi Chen , Grace Qian , Guo-Wei Wei
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