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Objective: To compare non-contact acoustic micro-tapping optical coherence elastography (AuT-OCE) with destructive mechanical tests to confirm corneal elastic anisotropy. Design: Ex vivo, laboratory study with non-contact AuT-OCE followed…

Purpose: To evaluate changes in the anisotropic elastic properties of ex vivo human cornea treated with UV cross-linking (CXL) using non-contact acoustic micro-tapping Optical Coherence Elastography (AuT-OCE) Design: AuT performed on normal…

Objective: The mechanical properties of corneal tissues play a crucial role in determining corneal shape and have significant implications in vision care. This study aimed to address the challenge of obtaining accurate in vivo data for the…

Medical Physics · Physics 2023-07-11 Guo-Yang Li , Xu Feng , Seok-Hyun Yun

The cornea provides the largest refractive power for the human visual system. Its stiffness, along with intraocular pressure (IOP), are linked to several pathologies, including keratoconus and glaucoma. Although mechanical tests can…

Understanding corneal stiffness is valuable for improving refractive surgery, detecting corneal abnormalities, and assessing intraocular pressure. However, accurately measuring the elastic properties, particularly the tensile and shear…

Medical Physics · Physics 2023-08-11 Guo-Yang Li , Xu Feng , Seok-Hyun Yun

The mechanical properties of arterial walls are critical for maintaining vascular function under pulsatile pressure and are closely linked to the development of cardiovascular diseases. Despite advances in imaging and elastography,…

Biological Physics · Physics 2025-07-29 Yuxuan Jiang , Guo-Yang Li , Ruizhi Wang , Xu Feng , Yanhang Zhang , Seok-Hyun Yun

Lens tension is essential for accommodative vision but remains difficult to measure with precision. Here, we present an optical coherence elastography (OCE) technique that quantifies both tension and elastic modulus in the lens capsule and…

Applied Physics · Physics 2025-12-29 Xu Feng , Guo-yang Li , Yuxuan Jiang , Owen Shortt-Nguyen , Seok-Hyun Yun

Traveling-wave optical coherence elastography (OCE) is a promising technique to measure the stiffness of biological tissues. While OCE has been applied to relatively homogeneous samples, tissues with significantly varying elasticity through…

Medical Physics · Physics 2022-01-31 Xu Feng , Guo-Yang Li , Antoine Ramier , Amira M. Eltony , Seok-Hyun Yun

We studied the elastic properties of bone to analyze its mechanical behavior. The basic principles of ultrasonic methods are now well established for varying isotropic media, particularly in the field of biomedical engineering. However,…

Classical Physics · Physics 2007-05-23 Martine Pithioux , P. Lasaygues , P. Chabrand

Robot-assisted surgery has advantages compared to conventional laparoscopic procedures, e.g., precise movement of the surgical instruments, improved dexterity, and high-resolution visualization of the surgical field. However, mechanical…

Image and Video Processing · Electrical Eng. & Systems 2025-01-28 Maximilian Neidhardt , Robin Mieling , Sarah Latus , Martin Fischer , Tobias Maurer , Alexander Schlaefer

Optical Coherence Tomography (OCT) is a non-invasive depth resolved optical imaging modality, that enables high resolution, cross-sectional imaging in biological tissues and materials at clinically relevant depths. Though OCT offers high…

Medical Physics · Physics 2020-05-29 Cerine Lal , Sergey Alexandrov , Sweta Rani , Yi Zhou , Thomas Ritter , Martin Leahy

Corneal collagen crosslinking (CXL) is commonly used to prevent or treat keratoconus. Although changes in corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic optical coherence elastography (OCE) by tracking…

Collagen crosslinking of the cornea (CXL) is commonly employed to prevent or treat keratoconus. Although the change of corneal stiffness induced by CXL surgery can be monitored with non-contact dynamic Optical Coherence Elastography (OCE)…

We derive closed-form solutions for reverberant elastography in anisotropic elastic media by adapting the framework used in electromagnetic theory to treat transverse isotropic materials. Different sample-setup geometries are analyzed,…

Medical Physics · Physics 2020-11-12 Luis A. Aleman-Castaneda , Fernando Zvietcovich , Kevin J. Parker

Optical coherence elastography (OCE) is a powerful non-invasive imaging technique for high-resolution assessment of tissue elasticity and viscoelasticity. Accurate characterization of viscoelastic properties requires estimating shear wave…

Displacement estimation in optical coherence tomography (OCT) imaging is relevant for several potential applications, e.g. for optical coherence elastography (OCE) for corneal biomechanical characterization. Larger displacements may be…

Image and Video Processing · Electrical Eng. & Systems 2021-03-22 Hossein Khodadadi , Orcun Goksel , Sabine Kling

Elasticity is a fundamental cellular property that is related to the anatomy, functionality and pathological state of cells and tissues. However, current techniques based on cell deformation, atomic force microscopy or Brillouin scattering…

Dynamic optical coherence elastography (OCE) tracks mechanical wave propagation in the subsurface region of tissue to image its shear modulus. For bulk shear waves, the lateral resolution of the reconstructed modulus map (i.e.,…

We have developed a multimodal photoacoustic remote sensing (PARS) microscope combined with swept source optical coherence tomography for in vivo, non-contact retinal imaging. Building on the proven strength of multiwavelength PARS imaging,…

Detection of Barrett's esophagus (BE) at points of care outside the endoscopy suite may improve screening access and reduce esophageal adenocarcinoma mortality. Tethered capsule optical coherence tomography (OCT) can volumetrically image…

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