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The alignment of biological networks has the potential to teach us as much about biology and disease as has sequence alignment. Sequence alignment can be optimally solved in polynomial time. In contrast, network alignment is $NP$-hard,…

Molecular Networks · Quantitative Biology 2016-07-12 Nil Mamano , Wayne Hayes

Multiple sequence alignment is a basic procedure in molecular biology, and it is often treated as being essentially a solved computational problem. However, this is not so, and here I review the evidence for this claim, and outline the…

Populations and Evolution · Quantitative Biology 2018-08-24 David A. Morrison

This paper describes a new alignment algorithm for sequences that can be used for determination of deletions and substitutions. It provides several solutions out of which the best one can be chosen on the basis of minimization of gaps or…

Information Theory · Computer Science 2012-11-01 Sandeep Hosangadi , Subhash Kak

Genome sequence alignment is the core of many biological applications. The advancement of sequencing technologies produces a tremendous amount of data, making sequence alignment a critical bottleneck in bioinformatics analysis. The existing…

Hardware Architecture · Computer Science 2023-01-26 Weihong Xu , Saransh Gupta , Niema Moshiri , Tajana Rosing

Many techniques in program synthesis, superoptimization, and array programming require parallel rollouts of general-purpose programs. GPUs, while capable targets for domain-specific parallelism, are traditionally underutilized by such…

Programming Languages · Computer Science 2026-04-15 Breandan Considine

Mamba-based State Space Models (SSM) have emerged as a promising alternative to the ubiquitous transformers. Despite the expressive power of transformers, the quadratic complexity of computing attention is a major impediment to scaling…

Machine Learning · Computer Science 2025-08-26 Trinayan Baruah , Kaustubh Shivdikar , Sara Prescott , David Kaeli

High-performance implementations of graph algorithms are challenging to implement on new parallel hardware such as GPUs because of three challenges: (1) the difficulty of coming up with graph building blocks, (2) load imbalance on parallel…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-06-16 Carl Yang , Aydin Buluc , John D. Owens

Transformer models have emerged as the leading approach for achieving state-of-the-art performance across various application domains, serving as the foundation for advanced large-scale deep learning (DL) models. However, efficiently…

Machine Learning · Computer Science 2024-09-06 Yujie Wang , Youhe Jiang , Xupeng Miao , Fangcheng Fu , Shenhan Zhu , Xiaonan Nie , Yaofeng Tu , Bin Cui

Extensive prior research has focused on alleviating the characteristic poor cache locality of graph analytics workloads. However, graph pre-processing tasks remain relatively unexplored. In many important scenarios, graph pre-processing…

Hardware Architecture · Computer Science 2020-11-18 Vignesh Balaji , Brandon Lucia

We present a novel characterization of the mapping of multiple parallelism forms (e.g. data and model parallelism) onto hierarchical accelerator systems that is hierarchy-aware and greatly reduces the space of software-to-hardware mapping.…

Programming Languages · Computer Science 2021-11-17 Ningning Xie , Tamara Norman , Dominik Grewe , Dimitrios Vytiniotis

GPUs running deep learning (DL) workloads are frequently underutilized. Collocating multiple DL training tasks on the same GPU can improve utilization but introduces two key risks: (1) out-of-memory (OOM) crashes for newly scheduled tasks,…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-24 Ehsan Yousefzadeh-Asl-Miandoab , Florina M. Ciorba , Pınar Tözün

With the breakthrough of Transformer-based pre-trained models, the demand for fine-tuning (FT) to adapt the base pre-trained models to downstream applications continues to grow, so it is essential for service providers to reduce the cost of…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-09-03 Sheng Lin , Fangcheng Fu , Haoyang Li , Hao Ge , Xuanyu Wang , Jiawen Niu , Yaofeng Tu , Bin Cui

Code localization constitutes a key bottleneck in automated software development pipelines. While concurrent tool execution can enhance discovery speed, current agents demonstrate a 34.9\% redundant invocation rate, which negates…

Artificial Intelligence · Computer Science 2026-01-28 Ke Xu , Siyang Xiao , Ming Liang , Yichen Yu , Zhixiang Wang , Jingxuan Xu , Dajun Chen , Wei Jiang , Yong Li

In this paper we introduce Shackleton as a generalized framework enabling the application of linear genetic programming -- a technique under the umbrella of evolutionary algorithms -- to a variety of use cases. We also explore here a novel…

Neural and Evolutionary Computing · Computer Science 2022-02-01 Hannah Peeler , Shuyue Stella Li , Andrew N. Sloss , Kenneth N. Reid , Yuan Yuan , Wolfgang Banzhaf

Graph partition is a key component to achieve workload balance and reduce job completion time in parallel graph processing systems. Among the various partition strategies, edge partition has demonstrated more promising performance in…

Data Structures and Algorithms · Computer Science 2020-12-18 Zhenyu Guo , Mingyu Xiao , Yi Zhou , Dongxiang Zhang , Kian-Lee Tan

Training large-scale deep learning models has become a key challenge for the scientific community and industry. While the massive use of GPUs can significantly speed up training times, this approach has a negative impact on efficiency. In…

Machine Learning · Computer Science 2025-09-04 David Cortes , Carlos Juiz , Belen Bermejo

We study exact sparse linear regression with an $\ell_0-\ell_2$ penalty and develop a branch-and-bound (BnB) algorithm explicitly designed for GPU execution. Starting from a perspective reformulation, we derive an interval relaxation that…

Optimization and Control · Mathematics 2026-02-05 Xiang Meng , Ryan Lucas , Rahul Mazumder

This paper investigates co-scheduling algorithms for processing a set of parallel applications. Instead of executing each application one by one, using a maximum degree of parallelism for each of them, we aim at scheduling several…

Data Structures and Algorithms · Computer Science 2013-05-01 Guillaume Aupy , Manu Shantharam , Anne Benoit , Yves Robert , Padma Raghavan

GPUs are readily available in cloud computing and personal devices, but their use for data processing acceleration has been slowed down by their limited integration with common programming languages such as Python or Java. Moreover, using…

Distributed, Parallel, and Cluster Computing · Computer Science 2021-01-20 Alberto Parravicini , Arnaud Delamare , Marco Arnaboldi , Marco D. Santambrogio

Kernel segmentation aims at partitioning a data sequence into several non-overlapping segments that may have nonlinear and complex structures. In general, it is formulated as a discrete optimization problem with combinatorial constraints. A…

Machine Learning · Computer Science 2022-06-23 Tung Doan , Atsuhiro Takasu
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