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A vast array of transformative technologies developed over the past decade has enabled measurement and perturbation at ever increasing scale, yet our understanding of many systems remains limited by experimental capacity. Overcoming this…

Quantitative Methods · Quantitative Biology 2020-12-25 Brian Cleary , Aviv Regev

Complex systems fail. I argue that failures can be a blueprint characterizing living organisms and biological intelligence, a control mechanism to increase complexity in evolutionary simulations, and an alternative to classical fitness…

Artificial Intelligence · Computer Science 2021-02-25 Lana Sinapayen

Since its inception, the choice modelling field has been dominated by theory-driven modelling approaches. Machine learning offers an alternative data-driven approach for modelling choice behaviour and is increasingly drawing interest in our…

Econometrics · Economics 2023-08-17 S. Van Cranenburgh , S. Wang , A. Vij , F. Pereira , J. Walker

A modeling formalism is proposed for the description and study of living and life-like systems. It provides an abstract conceptual model framework for real life and evolution of biological organisms. It is proposed, that this model…

Populations and Evolution · Quantitative Biology 2013-06-14 Margareta Segerståhl

The development of deep learning algorithms has extensively empowered humanity's task automatization capacity. However, the huge improvement in the performance of these models is highly correlated with their increasing level of complexity,…

Computer Vision and Pattern Recognition · Computer Science 2024-01-19 Eduarda Caldeira , Pedro C. Neto , Marco Huber , Naser Damer , Ana F. Sequeira

In this paper, we argue that the prevailing approach to training and evaluating machine learning models often fails to consider their real-world application within organizational or societal contexts, where they are intended to create…

Machine Learning · Computer Science 2025-04-24 Burcu Sayin , Jie Yang , Xinyue Chen , Andrea Passerini , Fabio Casati

The implementation of deep learning algorithms has brought new perspectives to plankton ecology. Emerging as an alternative approach to established methods, deep learning offers objective schemes to investigate plankton organisms in diverse…

Biologists and physicists have a rich tradition of modeling living systems with simple models composed of a few interacting components. Despite the remarkable success of this approach, it remains unclear how to use such finely tuned models…

Biological Physics · Physics 2025-09-05 Ilya Nemenman , Pankaj Mehta

System and synthetic biology are rapidly evolving systems, but both lack tools such as those used in engineering environments to shift the their focus from the design of parts (details) to the design of systems (behaviors); to aggravate,…

Emerging Technologies · Computer Science 2015-07-29 Ricardo Henrique Gracini Guiraldelli , Vincenzo Manca

We consider a lifelong learning scenario in which a learner faces a neverending and arbitrary stream of facts and has to decide which ones to retain in its limited memory. We introduce a mathematical model based on the online learning…

Machine Learning · Computer Science 2022-01-13 Robi Bhattacharjee , Gaurav Mahajan

A perceived limitation of evolutionary art and design algorithms is that they rely on human intervention; the artist selects the most aesthetically pleasing variants of one generation to produce the next. This paper discusses how computer…

Artificial Intelligence · Computer Science 2019-07-11 Steve DiPaola , Liane Gabora

Missing data is a fundamental challenge in data science, significantly hindering analysis and decision-making across a wide range of disciplines, including healthcare, bioinformatics, social science, e-commerce, and industrial monitoring.…

Machine Learning · Statistics 2026-05-12 Jicong Fan

Causal models and methods have great promise, but their progress has been stalled. Proposals using causality get squeezed between two opposing worldviews. Scientific perfectionism--an insistence on only using "correct" models--slows the…

Computers and Society · Computer Science 2024-06-05 Joshua Loftus

This paper focuses on the problem of 3D human reconstruction from 2D evidence. Although this is an inherently ambiguous problem, the majority of recent works avoid the uncertainty modeling and typically regress a single estimate for a given…

Computer Vision and Pattern Recognition · Computer Science 2021-08-27 Nikos Kolotouros , Georgios Pavlakos , Dinesh Jayaraman , Kostas Daniilidis

There are enormous amount of examples of Computation in nature, exemplified across multiple species in biology. One crucial aim for these computations across all life forms their ability to learn and thereby increase the chance of their…

Machine Learning · Computer Science 2013-12-30 Nabarun Mondal , Partha P. Ghosh

Mathematical models are routinely applied to interpret biological data, with common goals that include both prediction and parameter estimation. A challenge in mathematical biology, in particular, is that models are often complex and…

Methodology · Statistics 2025-11-18 Alexander P Browning , Jennifer A Flegg , Ryan J Murphy

The goal of Artificial Life research, as articulated by Chris Langton, is "to contribute to theoretical biology by locating life-as-we-know-it within the larger picture of life-as-it-could-be" (1989, p.1). The study and pursuit of…

Artificial Intelligence · Computer Science 2022-09-20 James M. Borg , Andrew Buskell , Rohan Kapitany , Simon T. Powers , Eva Reindl , Claudio Tennie

As scientists living through a climate emergency, we have a responsibility to lead by example, or to at least be consistent with our understanding of the problem. This common goal of reducing the carbon footprint of our work can be…

Modeling biological processes is a highly demanding task because not all processes are fully understood. Mathematical models allow us to test hypotheses about possible mechanisms of biological processes. The mathematical mechanisms…

Numerical Analysis · Mathematics 2023-12-11 Cordula Reisch , Hannah Burmester

Mathematical reasoning is essential for problem-solving in education, science, and industry, serving as a crucial benchmark for evaluating artificial intelligence systems. As Large Language Models (LLMs) improve their reasoning…

Computation and Language · Computer Science 2026-05-20 Husnain Amjad , Raja Khurram Shahzad , Aamir Shahzad , Mehwish Fatima
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