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Functional magnetic resonance imaging (fMRI) provides an indirect measurement of neuronal activity via hemodynamic responses that vary across brain regions and individuals. Ignoring this hemodynamic variability can bias downstream…

Image and Video Processing · Electrical Eng. & Systems 2026-01-26 William Consagra , Eardi Lila

Purpose: Functional magnetic resonance imaging (fMRI) and functional connectivity (FC) have been used to follow aging in both children and older adults. Robust changes have been observed in children, where high connectivity among all brain…

Neurons and Cognition · Quantitative Biology 2023-08-28 Anton Orlichenko , Kuan-Jui Su , Qing Tian , Hui Shen , Hong-Wen Deng , Yu-Ping Wang

Fetal functional Magnetic Resonance Imaging (fMRI) has emerged as a powerful tool for investigating brain development in utero, holding promise for generating developmental disease biomarkers and supporting prenatal diagnosis. However, to…

Functional connectivity (FC) studies have demonstrated the overarching value of studying the brain and its disorders through the undirected weighted graph of fMRI correlation matrix. Most of the work with the FC, however, depends on the way…

Neurons and Cognition · Quantitative Biology 2021-12-09 Usman Mahmood , Zening Fu , Vince Calhoun , Sergey Plis

Brain networks can be defined and explored through their connectivity. Here, we analyzed the relationship between structural connectivity (SC) across 2,514 regions that cover the entire brain and brainstem, and their dynamic functional…

Neuroimaging-based prediction methods for intelligence and cognitive abilities have seen a rapid development in literature. Among different neuroimaging modalities, prediction based on functional connectivity (FC) has shown great promise.…

Neurons and Cognition · Quantitative Biology 2023-07-20 Yang Li , Xin Ma , Raj Sunderraman , Shihao Ji , Suprateek Kundu

Psychiatric research has been hampered by an explanatory gap between psychiatric symptoms and their neural underpinnings, which has resulted in poor treatment outcomes. This situation has prompted us to shift from symptom-based diagnosis to…

We investigate the relationship of resting-state fMRI functional connectivity estimated over long periods of time with time-varying functional connectivity estimated over shorter time intervals. We show that using Pearson's correlation to…

Neurons and Cognition · Quantitative Biology 2016-09-08 Richard F. Betzel , Makoto Fukushima , Ye He , Xi-Nian Zuo , Olaf Sporns

Alzheimer's disease (AD) is the most prevalent form of dementia. Traditional methods cannot achieve efficient and accurate diagnosis of AD. In this paper, we introduce a novel method based on dynamic functional connectivity (dFC) that can…

Computer Vision and Pattern Recognition · Computer Science 2020-06-25 Xingwei An , Yutao Zhou , Yang Di , Dong Ming

Dynamic functional connectivity analysis provides valuable information for understanding brain functional activity underlying different cognitive processes. Besides sliding window based approaches, a variety of methods have been developed…

Computer Vision and Pattern Recognition · Computer Science 2018-09-18 Hongming Li , Yong Fan

We introduce a novel framework that integrates Hodge decomposition with Filtered Average Short-Term (FAST) functional connectivity to analyze dynamic functional connectivity (DFC) in EEG signals. This method leverages graph-based topology…

Signal Processing · Electrical Eng. & Systems 2025-02-10 Om Roy , Yashar Moshfeghi , Jason Smith , Agustin Ibanez , Mario A. Parra , Keith M. Smith

Precision psychiatry aspires to elucidate brain-based biomarkers of psychopathology to bolster disease risk assessment and treatment development. To this end, functional magnetic resonance imaging (fMRI) has helped triangulate brain…

Neurons and Cognition · Quantitative Biology 2026-01-23 Cole Korponay

This study addresses the challenge of predicting post-stroke rigidity by emphasizing feature interactions through graph-based explainable AI. Post-stroke rigidity, characterized by increased muscle tone and stiffness, significantly affects…

Machine learning offers great potential for automated prediction of post-stroke symptoms and their response to rehabilitation. Major challenges for this endeavour include the very high dimensionality of neuroimaging data, the relatively…

Artificial Intelligence · Computer Science 2023-10-31 Adam White , Margarita Saranti , Artur d'Avila Garcez , Thomas M. H. Hope , Cathy J. Price , Howard Bowman

Stroke is a common disabling neurological condition that affects about one-quarter of the adult population over age 25; more than half of patients still have poor outcomes, such as permanent functional dependence or even death, after the…

Computer Vision and Pattern Recognition · Computer Science 2024-02-19 Chia-Ling Tsai , Hui-Yun Su , Shen-Feng Sung , Wei-Yang Lin , Ying-Ying Su , Tzu-Hsien Yang , Man-Lin Mai

One third of stroke survivors have language difficulties. Emerging evidence suggests that their likelihood of recovery depends mainly on the damage to language centers. Thus previous research for predicting language recovery post-stroke has…

Computer Vision and Pattern Recognition · Computer Science 2018-11-28 Yusuf H. Roohani , Noor Sajid , Pranava Madhyastha , Cathy J. Price , Thomas M. H. Hope

In this study, we utilized statistical analysis and machine learning methods to examine whether rehabilitation exercises can improve patients post-stroke functional abilities, as well as forecast the improvement in functional abilities. Our…

Neurofeedback cognitive training is a promising tool used to promote cognitive functions effectively and efficiently. In this study, we investigated a novel functional near-infrared spectroscopy (fNIRS)-based frontoparietal functional…

Neurons and Cognition · Quantitative Biology 2021-06-03 Meiyun Xia , Pengfei Xu , Yuanbin Yang , Wenyu Jiang , Zehua Wang , Xiaolei Gu , Mingxi Yang , Deyu Li , Shuyu Li , Guijun Dong , Ling Wang , Daifa Wang

Functional magnetic resonance imaging (fMRI) is widely used in clinical applications to highlight brain areas involved in specific cognitive processes. Brain impairments, such as tumors, suppress the fMRI activation of the anatomical areas…

Neurons and Cognition · Quantitative Biology 2019-06-20 Qiongge Li , Gino Del Ferraro , Luca Pasquini , Kyung K. Peck , Hernan A. Makse , Andrei I. Holodny

We present a didactic introduction to spectral Dynamic Causal Modelling (DCM), a Bayesian state-space modelling approach used to infer effective connectivity from non-invasive neuroimaging data. Spectral DCM is currently the most widely…

Neurons and Cognition · Quantitative Biology 2023-09-07 Leonardo Novelli , Karl Friston , Adeel Razi