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Realistic simulations of detailed, biophysics-based, multi-scale models require very high resolution and, thus, large-scale compute facilities. Existing simulation environments, especially for biomedical applications, are designed to allow…

Computational Engineering, Finance, and Science · Computer Science 2018-02-12 Chris Bradley , Nehzat Emamy , Thomas Ertl , Dominik Göddeke , Andreas Hessenthaler , Thomas Klotz , Aaron Krämer , Michael Krone , Benjamin Maier , Miriam Mehl , Tobias Rau , Oliver Röhrle

The development of artificial intelligence systems is transitioning from creating static, task-specific models to dynamic, agent-based systems capable of performing well in a wide range of applications. We propose an Interactive Agent…

In our research we investigate the output accuracy of discrete event simulation models and agent based simulation models when studying human centric complex systems. In this paper we focus on human reactive behaviour as it is possible in…

Artificial Intelligence · Computer Science 2010-07-05 Mazlina Abdul Majid , Uwe Aickelin , Peer-Olaf Siebers

Simulation serves as a third way of doing science, in contrast to both induction and deduction. The web based modeling may considerably facilitate the execution of simulations by other people. We present examples of agent-based and…

Physics and Society · Physics 2011-04-15 V. Daniunas , V. Gontis , A. Kononovicius

We introduce AgentSynth, a scalable and cost-efficient pipeline for automatically synthesizing high-quality tasks and trajectory datasets for generalist computer-use agents. Leveraging information asymmetry, AgentSynth constructs subtasks…

Computation and Language · Computer Science 2026-03-03 Jingxu Xie , Dylan Xu , Xuandong Zhao , Dawn Song

We introduce DABstep, a novel benchmark for evaluating AI agents on realistic multi-step data analysis tasks. DABstep comprises over 450 real-world challenges derived from a financial analytics platform, requiring models to combine…

Machine Learning · Computer Science 2025-07-01 Alex Egg , Martin Iglesias Goyanes , Friso Kingma , Andreu Mora , Leandro von Werra , Thomas Wolf

Evolutionary multi-agent systems (EMASs) are very good at dealing with difficult, multi-dimensional problems, their efficacy was proven theoretically based on analysis of the relevant Markov-Chain based model. Now the research continues on…

Neural and Evolutionary Computing · Computer Science 2022-10-25 Mateusz Godzik , Jacek Dajda , Marek Kisiel-Dorohinicki , Aleksander Byrski , Leszek Rutkowski , Patryk Orzechowski , Joost Wagenaar , Jason H. Moore

In recent years, dynamic agent-based population models, which model every inhabitant of a country as a statistically representative agent, have been gaining in popularity for decision support. This is mainly due to their high degree of…

Multiagent Systems · Computer Science 2025-11-11 Martin Bicher , Maximilian Viehauser , Daniele Giannandrea , Hannah Kastinger , Dominik Brunmeir , Niki Popper

We envision the Full-Body AI Agent as a comprehensive AI system designed to simulate, analyze, and optimize the dynamic processes of the human body across multiple biological levels. By integrating computational models, machine learning…

Tissues and Organs · Quantitative Biology 2025-08-28 Aoqi Wang , Jiajia Liu , Jianguo Wen , Yangyang Luo , Zhiwei Fan , Liren Yang , Xi Hu , Ruihan Luo , Yankai Yu , Sophia Li , Weiling Zhao , Xiaobo Zhou

Taking agent-based models (ABM) closer to the data is an open challenge. This paper explicitly tackles parameter space exploration and calibration of ABMs combining supervised machine-learning and intelligent sampling to build a surrogate…

Economics · Quantitative Finance 2017-04-07 Francesco Lamperti , Andrea Roventini , Amir Sani

Agent-based simulation provides a powerful tool for in silico system modeling. However, these simulations do not provide built-in methods for uncertainty quantification (UQ). Within these types of models a typical approach to UQ is to run…

Applications · Statistics 2025-04-17 Adam Spannaus , Sifat Afroj Moon , John Gounley , Heidi A. Hanson

Running agent-based models (ABMs) is a burdensome computational task, specially so when considering the flexibility ABMs intrinsically provide. This paper uses a bundle of model configuration parameters along with obtained results from a…

Multiagent Systems · Computer Science 2020-01-14 Bernardo Alves Furtado

Hyperparameter optimization is critical in modern machine learning, requiring expert knowledge, numerous trials, and high computational and human resources. Despite the advancements in Automated Machine Learning (AutoML), challenges in…

Machine Learning · Computer Science 2025-02-27 Siyi Liu , Chen Gao , Yong Li

Business process simulation (BPS) is a versatile technique for estimating process performance across various scenarios. Traditionally, BPS approaches employ a control-flow-first perspective by enriching a process model with simulation…

Multiagent Systems · Computer Science 2024-08-19 Lukas Kirchdorfer , Robert Blümel , Timotheus Kampik , Han van der Aa , Heiner Stuckenschmidt

The rapid development of large language model (LLM)-based agents has unlocked new possibilities for autonomous multi-turn reasoning and tool-augmented decision-making. However, their real-world deployment is hindered by severe…

Virtual cell modeling aims to predict cellular responses to diverse perturbations but faces challenges from biological complexity, multimodal data heterogeneity, and the need for interdisciplinary expertise. We introduce CellForge, a…

There is great potential to be explored regarding the use of agent-based modelling and simulation as an alternative paradigm to investigate early-stage cancer interactions with the immune system. It does not suffer from some limitations of…

Multiagent Systems · Computer Science 2015-06-22 Grazziela P Figueredo , Peer-Olaf Siebers , Markus R Owen , Jenna Reps , Uwe Aickelin

Multi-agent simulations enables the modeling and analyses of the dynamic behaviors and interactions of autonomous entities evolving in complex environments. Agent-based models (ABM) are widely used to study emergent phenomena arising from…

Machine Learning · Computer Science 2025-05-20 Paul Saves , Nicolas Verstaevel , Benoît Gaudou

Large Language Models (LLMs) have increasingly demonstrated the ability to facilitate the development of multi-agent systems that allow the interpretation of thoughts and actions generated by each individual. Promising advancements have…

Multiagent Systems · Computer Science 2024-09-24 Asher Sprigler , Alexander Drobek , Keagan Weinstock , Wendpanga Tapsoba , Gavin Childress , Andy Dao , Lucas Gral

As autonomous driving systems being deployed to millions of vehicles, there is a pressing need of improving the system's scalability, safety and reducing the engineering cost. A realistic, scalable, and practical simulator of the driving…

Robotics · Computer Science 2024-07-04 Yihan Hu , Siqi Chai , Zhening Yang , Jingyu Qian , Kun Li , Wenxin Shao , Haichao Zhang , Wei Xu , Qiang Liu