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The identification of synthetic routes that end with a desired product has been an inherently time-consuming process that is largely dependent on expert knowledge regarding a limited fraction of the entire reaction space. At present,…

Machine Learning · Statistics 2020-12-17 Zhongliang Guo , Stephen Wu , Mitsuru Ohno , Ryo Yoshida

Retrosynthesis is a technique to plan the chemical synthesis of organic molecules, for example drugs, agro- and fine chemicals. In retrosynthesis, a search tree is built by analysing molecules recursively and dissecting them into simpler…

Artificial Intelligence · Computer Science 2017-02-02 Marwin Segler , Mike Preuß , Mark P. Waller

Machine learning is revolutionizing chemistry. Beyond the value of predictive models accelerating virtual screening, generative AI aims at enabling inverse design, reversing the compound-to-property prediction paradigm into…

Retrosynthesis strategically plans the synthesis of a chemical target compound from simpler, readily available precursor compounds. This process is critical for synthesizing novel inorganic materials, yet traditional methods in inorganic…

Product take-back legislation forces manufacturers to bear the costs of collection and disposal of products that have reached the end of their useful lives. In order to reduce these costs, manufacturers can consider reuse, remanufacturing…

Artificial Intelligence · Computer Science 2010-12-21 Bo Xing , Wen-Jing Gao , Kimberly Battle , Tshildzi Marwala , Fulufhelo V. Nelwamondo

Retrosynthesis prediction aims to infer the reactant molecule based on a given product molecule, which is a fundamental task in chemical synthesis. However, existing models rely on static pattern-matching paradigm, which limits their…

Machine Learning · Computer Science 2025-12-08 Xinyi Li , Sai Wang , Yutian Lin , Yu Wu , Yi Yang

Drug addiction is a complex and pervasive global challenge that continues to pose significant public health concerns. Traditional approaches to anti-addiction drug discovery have struggled to deliver effective therapeutics, facing high…

Biomolecules · Quantitative Biology 2025-02-11 Dong Chen , Jian Jiang , Zhe Su , Guo-Wei Wei

Retrosynthesis is one of the fundamental problems in organic chemistry. The task is to identify reactants that can be used to synthesize a specified product molecule. Recently, computer-aided retrosynthesis is finding renewed interest from…

Machine Learning · Computer Science 2020-01-07 Hanjun Dai , Chengtao Li , Connor W. Coley , Bo Dai , Le Song

Retrosynthetic planning is a fundamental problem in chemistry for finding a pathway of reactions to synthesize a target molecule. Recently, search algorithms have shown promising results for solving this problem by using deep neural…

Machine Learning · Computer Science 2021-06-10 Junsu Kim , Sungsoo Ahn , Hankook Lee , Jinwoo Shin

Molecular retrosynthesis is a significant and complex problem in the field of chemistry, however, traditional manual synthesis methods not only need well-trained experts but also are time-consuming. With the development of big data and…

Artificial Intelligence · Computer Science 2024-07-16 Yan Zhang , Hao Hao , Xiao He , Shuanhu Gao , Aimin Zhou

Drug discovery is adapting to novel technologies such as data science, informatics, and artificial intelligence (AI) to accelerate effective treatment development while reducing costs and animal experiments. AI is transforming drug…

Artificial Intelligence · Computer Science 2023-07-14 Catrin Hasselgren , Tudor I. Oprea

Retrosynthesis analysis is a critical task in organic chemistry central to many important industries. Previously, various machine learning approaches have achieved promising results on this task by representing output molecules as strings…

Quantitative Methods · Quantitative Biology 2022-09-20 Lei Fang , Junren Li , Ming Zhao , Li Tan , Jian-Guang Lou

Artificial neural networks learn various rules and algorithms to form different ways of processing information, and have been widely used in various chemical processes. Among them, with the development of rectification technology, its…

Machine Learning · Computer Science 2021-10-05 Jing Sun , Qi Tang

Advancements in artificial intelligence (AI) have transformed many scientific fields, with microbiology and microbiome research now experiencing significant breakthroughs through machine learning applications. This review provides a…

Quantitative Methods · Quantitative Biology 2025-12-19 Xu-Wen Wang , Tong Wang , Yang-Yu Liu

Retrosynthesis is a problem to infer reactant compounds to synthesize a given product compound through chemical reactions. Recent studies on retrosynthesis focus on proposing more sophisticated prediction models, but the dataset to feed the…

Machine Learning · Computer Science 2020-10-05 Katsuhiko Ishiguro , Kazuya Ujihara , Ryohto Sawada , Hirotaka Akita , Masaaki Kotera

High throughput experimentation tools, machine learning (ML) methods, and open material databases are radically changing the way new materials are discovered. From the experimentally driven approach in the past, we are moving quickly…

Materials Science · Physics 2025-08-06 Albertus Denny Handoko , Riko I Made

Materials design is an important component of modern science and technology, yet traditional approaches rely heavily on trial-and-error and can be inefficient. Computational techniques, enhanced by modern artificial intelligence (AI), have…

Artificial intelligence (AI) and data science are transforming chemical research, yet few formal courses are tailored to synthetic and experimental chemists, who often face steep entry barriers due to limited coding experience and lack of…

Artificial Intelligence · Computer Science 2026-04-10 Zhiling Zheng

Cancer is one of the leading causes of death worldwide. Fast and safe early-stage, pre- and intra-operative diagnostics can significantly contribute to successful cancer identification and treatment. Artificial intelligence has played an…

Tissues and Organs · Quantitative Biology 2022-08-10 Marina Zajnulina

Chemistry, a long-standing discipline, has historically relied on manual and often time-consuming processes. While some automation exists, the field is now on the cusp of a significant evolution driven by the integration of robotics and…

Robotics · Computer Science 2025-10-14 Jihong Zhu , Kefeng Huang , Jonathon Pipe , Chris Horbaczewsky , Andy Tyrrell , Ian J. S. Fairlamb