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A computational challenge to validate the candidate disease genes identified in a high-throughput genomic study is to elucidate the associations between the set of candidate genes and disease phenotypes. The conventional gene set enrichment…

Genomics · Quantitative Biology 2011-02-22 TaeHyun Hwang , Wei Zhang , Maoqiang Xie , Rui Kuang

RNA design, the task of finding a sequence that folds into a target secondary structure, has broad biological and biomedical impact but remains computationally challenging due to the exponentially large sequence space and exponentially many…

Machine Learning · Computer Science 2026-02-16 Milan Gautam , Ning Dai , Tianshuo Zhou , Bowen Xie , David Mathews , Liang Huang

Generative recommender systems have recently emerged as a promising paradigm by formulating next-item prediction as an auto-regressive semantic IDs generation, such as OneRec series works. However, with the next-item-agnostic prediction…

Information Retrieval · Computer Science 2026-04-29 Yu Liu , Jiangxia Cao

Text retrieval plays a crucial role in incorporating factual knowledge for decision making into language processing pipelines, ranging from chat-based web search to question answering systems. Current state-of-the-art text retrieval models…

Computation and Language · Computer Science 2024-11-26 Ge Gao , Jonathan D. Chang , Claire Cardie , Kianté Brantley , Thorsten Joachim

Many machine learning models have been proposed to classify phenotypes from gene expression data. In addition to their good performance, these models can potentially provide some understanding of phenotypes by extracting explanations for…

Genomics · Quantitative Biology 2024-02-05 Myriam Bontonou , Anaïs Haget , Maria Boulougouri , Benjamin Audit , Pierre Borgnat , Jean-Michel Arbona

Multi-label ranking maps instances to a ranked set of predicted labels from multiple possible classes. The ranking approach for multi-label learning problems received attention for its success in multi-label classification, with one of the…

Computer Vision and Pattern Recognition · Computer Science 2022-12-09 Emine Dari , V. Bugra Yesilkaynak , Alican Mertan , Gozde Unal

The comparison of alternative rankings of a set of items is a general and prominent task in applied statistics. Predictor variables are ranked according to magnitude of association with an outcome, prediction models rank subjects according…

To support complex search tasks, where the initial information requirements are complex or may change during the search, a search engine must adapt the information delivery as the user's information requirements evolve. To support this…

Information Retrieval · Computer Science 2021-05-24 Jianghong Zhou , Eugene Agichtein

Feature selection is important in data representation and intelligent diagnosis. Elastic net is one of the most widely used feature selectors. However, the features selected are dependant on the training data, and their weights dedicated…

Machine Learning · Computer Science 2021-01-01 Shaode Yu , Haobo Chen , Hang Yu , Zhicheng Zhang , Xiaokun Liang , Wenjian Qin , Yaoqin Xie , Ping Shi

One-class classification (OCC) deals with the classification problem in which the training data has data points belonging only to target class. In this paper, we study a one-class classification algorithm, One-Class Classification by…

Machine Learning · Computer Science 2020-03-10 Amir Ahmad , Srikanth Bezawada

Supervised operator learning centers on the use of training data, in the form of input-output pairs, to estimate maps between infinite-dimensional spaces. It is emerging as a powerful tool to complement traditional scientific computing,…

Machine Learning · Computer Science 2024-08-14 Nicholas H. Nelsen , Andrew M. Stuart

Deep neural networks (DNNs) achieve state-of-the-art results in a variety of domains. Unfortunately, DNNs are notorious for their non-interpretability, and thus limit their applicability in hypothesis-driven domains such as biology and…

Machine Learning · Computer Science 2018-03-12 Chun-Hao Chang , Ladislav Rampasek , Anna Goldenberg

Hierarchical taxonomies are common in many contexts, and they are a very natural structure humans use to organise information. In machine learning, the family of methods that use the 'extra' information is called hierarchical…

Machine Learning · Computer Science 2024-02-01 Ines Nolasco , Dan Stowell

The objective comparison of Reinforcement Learning (RL) algorithms is notoriously complex as outcomes and benchmarking of performances of different RL approaches are critically sensitive to environmental design, reward structures, and…

Machine Learning · Computer Science 2026-03-19 Sinan Ibrahim , Grégoire Ouerdane , Hadi Salloum , Henni Ouerdane , Stefan Streif , Pavel Osinenko

Predictive uncertainty-a model's self awareness regarding its accuracy on an input-is key for both building robust models via training interventions and for test-time applications such as selective classification. We propose a novel…

Machine Learning · Computer Science 2024-01-04 Nishant Jain , Karthikeyan Shanmugam , Pradeep Shenoy

In the face of rapidly accumulating genomic data, our understanding of the RNA regulatory code remains incomplete. Recent self-supervised methods in other domains have demonstrated the ability to learn rules underlying the data-generating…

Machine Learning · Computer Science 2023-10-18 Philip Fradkin , Ruian Shi , Bo Wang , Brendan Frey , Leo J. Lee

5G and beyond networks promise advancements in bandwidth, latency, and connectivity. The Open Radio Access Network (O-RAN) framework enhances flexibility through network slicing and closed-loop RAN control. Central to this evolution is…

Systems and Control · Electrical Eng. & Systems 2025-03-12 Joshua Groen , Zixian Yang , Divyadharshini Muruganandham , Mauro Belgiovine , Lei Ying , Kaushik Chowdhury

Learning-to-rank techniques have proven to be extremely useful for prioritization problems, where we rank items in order of their estimated probabilities, and dedicate our limited resources to the top-ranked items. This work exposes a…

Machine Learning · Statistics 2018-02-22 Cynthia Rudin , Yining Wang

In classification problems, sampling bias between training data and testing data is critical to the ranking performance of classification scores. Such bias can be both unintentionally introduced by data collection and intentionally…

Methodology · Statistics 2017-11-02 Chandler Zuo

Machine learning is increasingly deployed in safety-critical domains where erroneous predictions may lead to potentially catastrophic consequences, highlighting the need for learning systems to be aware of how confident they are in their…

Machine Learning · Computer Science 2025-02-18 Shireen Kudukkil Manchingal , Muhammad Mubashar , Kaizheng Wang , Keivan Shariatmadar , Fabio Cuzzolin