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An important challenge in cancer systems biology is to uncover the complex network of interactions between genes (tumor suppressor genes and oncogenes) implicated in cancer. Next generation sequencing provides unparalleled ability to probe…

Genomics · Quantitative Biology 2012-12-10 Ying Cai , Bernard Fendler , Gurinder S. Atwal

Learning to Rank is the problem involved with ranking a sequence of documents based on their relevance to a given query. Deep Q-Learning has been shown to be a useful method for training an agent in sequential decision making. In this…

Machine Learning · Computer Science 2020-02-19 Abhishek Sharma

Security research is fundamentally a problem of resource constraint and consequent prioritization. There is simply too much attack surface and too little time and energy to spend analyzing it all. The most effective security researchers are…

Cryptography and Security · Computer Science 2025-12-09 Caleb Gross

Encouraged by the success of deep learning in a variety of domains, we investigate the suitability and effectiveness of Recurrent Neural Networks (RNNs) in a domain where deep learning has not yet been used; namely detecting confusion from…

Computer Vision and Pattern Recognition · Computer Science 2019-06-27 Shane D. Sims , Vanessa Putnam , Cristina Conati

Fully exploiting ad-hoc microphone networks for distant speech recognition is still an open issue. Empirical evidence shows that being able to select the best microphone leads to significant improvements in recognition without any…

Audio and Speech Processing · Electrical Eng. & Systems 2021-04-15 Samuele Cornell , Alessio Brutti , Marco Matassoni , Stefano Squartini

We consider classification and regression tasks where we have missing data and assume that the (clean) data resides in a low rank subspace. Finding a hidden subspace is known to be computationally hard. Nevertheless, using a non-proper…

Machine Learning · Computer Science 2015-01-15 Elad Hazan , Roi Livni , Yishay Mansour

The alignment of biological networks has the potential to teach us as much about biology and disease as has sequence alignment. Sequence alignment can be optimally solved in polynomial time. In contrast, network alignment is $NP$-hard,…

Molecular Networks · Quantitative Biology 2016-07-12 Nil Mamano , Wayne Hayes

In medical image processing, accurate diagnosis is of paramount importance. Leveraging machine learning techniques, particularly top-rank learning, shows significant promise by focusing on the most crucial instances. However, challenges…

Computer Vision and Pattern Recognition · Computer Science 2025-08-12 Xiaotong Ji , Ryoma Bise , Seiichi Uchida

A central aim in computational neuroscience is to relate the activity of large populations of neurons to an underlying dynamical system. Models of these neural dynamics should ideally be both interpretable and fit the observed data well.…

Machine Learning · Computer Science 2025-02-27 Matthijs Pals , A Erdem Sağtekin , Felix Pei , Manuel Gloeckler , Jakob H Macke

Tree-based methods are powerful nonparametric techniques in statistics and machine learning. However, their effectiveness, particularly in finite-sample settings, is not fully understood. Recent applications have revealed their surprising…

Statistics Theory · Mathematics 2024-10-04 Hengrui Luo , Meng Li

Efficiently ranking relevant items from large candidate pools is a cornerstone of modern information retrieval systems -- such as web search, recommendation, and retrieval-augmented generation. Listwise rerankers, which improve relevance by…

Information Retrieval · Computer Science 2025-06-30 Evgeny Dedov

Background: Significance analysis plays a major role in identifying and ranking genes, transcription factor binding sites, DNA methylation regions, and other high-throughput features for association with disease. We propose a new approach,…

Methodology · Statistics 2017-01-10 Andrew E. Jaffe , John D. Storey , Hongkai Ji , Jeffrey T. Leek

Deep neural networks are a family of computational models that are naturally suited to the analysis of hierarchical data such as, for instance, sequential data with the use of recurrent neural networks. In the other hand, ordinal regression…

Machine Learning · Statistics 2021-01-08 Louis Falissard , Karim Bounebache , Grégoire Rey

Many real-world applications involve the use of Optical Character Recognition (OCR) engines to transform handwritten images into transcripts on which downstream Natural Language Processing (NLP) models are applied. In this process, OCR…

Computation and Language · Computer Science 2021-07-16 Guowei Xu , Wenbiao Ding , Weiping Fu , Zhongqin Wu , Zitao Liu

Recent genomic foundation models largely adopt large language model architectures that treat DNA as a one-dimensional token sequence. However, exhaustive sequential reading is structurally misaligned with sparse and discontinuous genomic…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Hongxin Xiang , Pengsen Ma , Yunkang Cao , Di Yu , Haowen Chen , Xinyu Yang , Xiangxiang Zeng

Large language models (LLMs) typically utilize the top-k contexts from a retriever in retrieval-augmented generation (RAG). In this work, we propose a novel instruction fine-tuning framework RankRAG, which instruction-tunes a single LLM for…

Computation and Language · Computer Science 2024-07-03 Yue Yu , Wei Ping , Zihan Liu , Boxin Wang , Jiaxuan You , Chao Zhang , Mohammad Shoeybi , Bryan Catanzaro

Industrial Retrieval-Augmented Generation (RAG) systems depend on optical character recognition (OCR) to transform visual documents into text. Existing OCR benchmarks rely on character-level metrics, which inadequately measure downstream…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Lin Sun , Wang Dexian , Jingang Huang , Linglin Zhang , Change Jia , Zhengwei Cheng , Xiangzheng Zhang

The problem of relevance ranking consists of sorting a set of objects with respect to a given criterion. Since users may prefer different relevance criteria, the ranking algorithms should be adaptable to the user needs. Two main approaches…

Machine Learning · Computer Science 2023-11-06 Leonardo Rigutini , Tiziano Papini , Marco Maggini , Franco Scarselli

State-of-the-art (SOTA) semi-supervised learning techniques, such as FixMatch and it's variants, have demonstrated impressive performance in classification tasks. However, these methods are not directly applicable to regression tasks. In…

Machine Learning · Computer Science 2024-10-30 Pin-Yen Huang , Szu-Wei Fu , Yu Tsao

Traditional recommendation systems suffer from inconsistency in multi-stage optimization objectives. Generative Recommendation (GR) mitigates them through an end-to-end framework; however, existing methods still rely on matching mechanisms…