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Tissue segmentation is an important pre-requisite for efficient and accurate diagnostics in digital pathology. However, it is well known that whole-slide scanners can fail in detecting all tissue regions, for example due to the tissue type,…

Computer Vision and Pattern Recognition · Computer Science 2017-04-04 Péter Bándi , Rob van de Loo , Milad Intezar , Daan Geijs , Francesco Ciompi , Bram van Ginneken , Jeroen van der Laak , Geert Litjens

Multi-modal learning plays a crucial role in cancer diagnosis and prognosis. Current deep learning based multi-modal approaches are often limited by their abilities to model the complex correlations between genomics and histology data,…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Yupei Zhang , Xiaofei Wang , Fangliangzi Meng , Jin Tang , Chao Li

Canine mammary carcinoma (CMC) has been used as a model to investigate the pathogenesis of human breast cancer and the same grading scheme is commonly used to assess tumor malignancy in both. One key component of this grading scheme is the…

Computer Vision and Pattern Recognition · Computer Science 2020-11-30 Marc Aubreville , Christof A. Bertram , Taryn A. Donovan , Christian Marzahl , Andreas Maier , Robert Klopfleisch

The presence of domain shift in medical imaging is a common issue, which can greatly impact the performance of segmentation models when dealing with unseen image domains. Adversarial-based deep learning models, such as Cycle-GAN, have…

Image and Video Processing · Electrical Eng. & Systems 2023-04-19 Paolo Iacono , Naimul Khan

Synthetic medical image generation has evolved as a key technique for neural network training and validation. A core challenge, however, remains in the domain gap between simulations and real data. While deep learning-based domain transfer…

We investigate the utility of in-domain self-supervised pre-training of vision models in the analysis of remote sensing imagery. Self-supervised learning (SSL) has emerged as a promising approach for remote sensing image classification due…

Computer Vision and Pattern Recognition · Computer Science 2024-02-06 Ivica Dimitrovski , Ivan Kitanovski , Nikola Simidjievski , Dragi Kocev

Supervised deep learning models often achieve excellent performance within their training distribution but struggle to generalize beyond it. In cancer histopathology, for example, a convolutional neural network (CNN) may classify cancer…

Computer Vision and Pattern Recognition · Computer Science 2026-01-22 Justin Cheung , Samuel Savine , Calvin Nguyen , Lin Lu , Alhassan S. Yasin

Deep learning models have shown immense promise in computational pathology (CPath) tasks, but their performance often suffers when applied to unseen data due to domain shifts. Addressing this requires domain generalization (DG) algorithms.…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Neda Zamanitajeddin , Mostafa Jahanifar , Kesi Xu , Fouzia Siraj , Nasir Rajpoot

Convolutional neural networks (CNNs) have shown promising results on several segmentation tasks in magnetic resonance (MR) images. However, the accuracy of CNNs may degrade severely when segmenting images acquired with different scanners…

Machine Learning · Statistics 2018-05-28 Neerav Karani , Krishna Chaitanya , Christian Baumgartner , Ender Konukoglu

Performance achievable by modern deep learning approaches are directly related to the amount of data used at training time. Unfortunately, the annotation process is notoriously tedious and expensive, especially for pixel-wise tasks like…

Computer Vision and Pattern Recognition · Computer Science 2018-10-16 Pierluigi Zama Ramirez , Alessio Tonioni , Luigi Di Stefano

Accurate and timely cancer diagnosis from histopathological slides is vital for effective clinical decision-making. This paper introduces DepViT-CAD, a deployable AI system for multi-class cancer diagnosis in histopathology. At its core is…

Image and Video Processing · Electrical Eng. & Systems 2025-07-15 Ashkan Shakarami , Lorenzo Nicole , Rocco Cappellesso , Angelo Paolo Dei Tos , Stefano Ghidoni

In this study, we introduce a multi-modal approach that efficiently integrates multi-scale clinical and dermoscopy features within a single network, thereby substantially reducing model parameters. The proposed method includes three novel…

Image and Video Processing · Electrical Eng. & Systems 2024-03-31 Peng Tang , Tobias Lasser

A key challenge in cancer immunotherapy biomarker research is quantification of pattern changes in microscopic whole slide images of tumor biopsies. Different cell types tend to migrate into various tissue compartments and form variable…

Computer Vision and Pattern Recognition · Computer Science 2018-09-25 Amal Lahiani , Jacob Gildenblat , Irina Klaman , Nassir Navab , Eldad Klaiman

We investigate the use of image-and-spatial transformer networks (ISTNs) to tackle domain shift in multi-site medical imaging data. Commonly, domain adaptation (DA) is performed with little regard for explainability of the inter-domain…

Image and Video Processing · Electrical Eng. & Systems 2020-10-27 R. Robinson , Q. Dou , D. C. Castro , K. Kamnitsas , M. de Groot , R. M. Summers , D. Rueckert , B. Glocker

This paper addresses the problem of few-shot skin disease classification by introducing a novel approach called the Sub-Cluster-Aware Network (SCAN) that enhances accuracy in diagnosing rare skin diseases. The key insight motivating the…

Computer Vision and Pattern Recognition · Computer Science 2023-11-27 Shuhan LI , Xiaomeng Li , Xiaowei Xu , Kwang-Ting Cheng

Domain shift in histopathology, often caused by differences in acquisition processes or data sources, poses a major challenge to the generalization ability of deep learning models. Existing methods primarily rely on modeling statistical…

Computer Vision and Pattern Recognition · Computer Science 2026-03-30 Kieu-Anh Truong Thi , Huy-Hieu Pham , Duc-Trong Le

Skin cancer is one of the most common and deadliest types of cancer. Early diagnosis of skin cancer at a benign stage is critical to reducing cancer mortality. To detect skin cancer at an earlier stage an automated system is compulsory that…

Computer Vision and Pattern Recognition · Computer Science 2024-06-21 Md Sirajul Islam , Sanjeev Panta

Foundation models trained with self-supervised learning (SSL) on large-scale histological images have significantly accelerated the development of computational pathology. These models can serve as backbones for region-of-interest (ROI)…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Jiawen Li , Jiali Hu , Xitong Ling , Yongqiang Lv , Yuxuan Chen , Yizhi Wang , Tian Guan , Yifei Liu , Yonghong He

Histopathological images provide rich information for disease diagnosis. Large numbers of histopathological images have been digitized into high resolution whole slide images, opening opportunities in developing computational image analysis…

Image and Video Processing · Electrical Eng. & Systems 2020-11-06 Jiayun Li , Wenyuan Li , Anthony Sisk , Huihui Ye , W. Dean Wallace , William Speier , Corey W. Arnold

We investigate the concept of deep barcodes and propose two methods to generate them in order to expedite the process of classification and retrieval of histopathology images. Since binary search is computationally less expensive, in terms…

Image and Video Processing · Electrical Eng. & Systems 2018-05-24 Meghana Dinesh Kumar , Morteza Babaie , Hamid Tizhoosh