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Cells continuously sense their surroundings to detect modifications and generate responses. Very often changes in extracellular concentrations initiate signaling cascades that eventually result in changes in gene expression. Increasing…

Cell Behavior · Quantitative Biology 2024-08-27 Alan Givré , Alejandro Colman-Lerner , Silvina Ponce Dawson

We study the problem of learning-based attacks in linear systems, where the communication channel between the controller and the plant can be hijacked by a malicious attacker. We assume the attacker learns the dynamics of the system from…

Systems and Control · Electrical Eng. & Systems 2021-05-21 Anshuka Rangi , Mohammad Javad Khojasteh , Massimo Franceschetti

Bounded rationality investigates utility-optimizing decision-makers with limited information-processing power. In particular, information theoretic bounded rationality models formalize resource constraints abstractly in terms of relative…

Artificial Intelligence · Computer Science 2018-09-07 Heinke Hihn , Sebastian Gottwald , Daniel A. Braun

Changes in a cell's external or internal conditions are usually reflected in the concentrations of the relevant transcription factors. These proteins in turn modulate the expression levels of the genes under their control and sometimes need…

Molecular Networks · Quantitative Biology 2013-08-01 Gasper Tkacik , Curtis G Callan , William Bialek

Spatially-embedded complex networks, such as nervous systems, the Internet and transportation networks, generally have non-trivial topological patterns of connections combined with nearly minimal wiring costs. However the growth rules…

Physics and Society · Physics 2013-05-09 Vincenzo Nicosia , Petra E. Vértes , William R. Schafer , Vito Latora , Edward T. Bullmore

An information-centric network should realize significant economies by exploiting a favourable memory-bandwidth tradeoff: it is cheaper to store copies of popular content close to users than to fetch them repeatedly over the Internet. We…

Networking and Internet Architecture · Computer Science 2013-09-23 James Roberts , Nada Sbihi

Multicellular organisms exhibit a high degree of structural organization with specific cell types always occurring in characteristic locations. The conventional framework for describing the emergence of such consistent spatial patterns is…

Tissues and Organs · Quantitative Biology 2022-05-11 Chandrashekar Kuyyamudi , Shakti N. Menon , Sitabhra Sinha

Living organisms survive and multiply even though they have uncertain and incomplete information about their environment and imperfect models to predict the consequences of their actions. Bayesian models have been proposed to face this…

Emerging Technologies · Computer Science 2015-11-13 Jacques Droulez , David Colliaux , Audrey Houillon , Pierre Bessière

Any learner with the ability to predict the future of a structured time-varying signal must maintain a memory of the recent past. If the signal has a characteristic timescale relevant to future prediction, the memory can be a simple shift…

Artificial Intelligence · Computer Science 2013-10-24 Karthik H. Shankar , Marc W. Howard

Living cells presumably employ optimized information transfer methods, enabling efficient communication even in noisy environments. As expected, the efficiency of chemical communications between cells depends on the properties of the…

Caching at the edge is a promising technique to cope with the increasing data demand in wireless networks. This paper analyzes the performance of cellular networks consisting of a tier macro-cell wireless backhaul nodes overlaid with a tier…

Information Theory · Computer Science 2017-05-25 Italo Atzeni , Marco Maso , Imène Ghamnia , Ejder Baştuğ , Mérouane Debbah

The technique of cooperative communication has recently gained momentum in the research community; this technique utilizes the notion of relay, as an intermediate node between the source and the destination, to enhance the overall system…

Networking and Internet Architecture · Computer Science 2010-01-20 Abbass Marouni , Youssef Nasser , Maryline Hélard , Haidar El-Mokdad

Feedback in sensory biochemical networks can give rise to bifurcations in cells' behavioral response. These bifurcations share many properties with thermodynamic critical points. Evidence suggests that biological systems may operate near…

Biological Physics · Physics 2020-12-04 Michael Vennettilli , Amir Erez , Andrew Mugler

Cells frequently employ extracellular vesicles, or exosomes, to signal across long distances and coordinate collective actions. Exosomes diffuse slowly, can be actively degraded, and contain stochastic amounts of molecular cargo. These…

Biological Physics · Physics 2025-10-15 Louis González , Andrew Mugler

Signaling pathways are responsible for the regulation of cell processes, such as monitoring the external environment, transmitting information across membranes, and making cell fate decisions. Given the increasing amount of biological data…

Molecular Networks · Quantitative Biology 2020-04-07 Daniel Inostroza , Cecilia Hernández , Diego Seco , Gonzalo Navarro , Alvaro Olivera-Nappa

Caching of popular contents at cellular base stations, i.e., edge caching, in order to eliminate duplicate transmission through the backhaul can reduce the latency of data delivery in $5$G networks. However, since caching can only reduce…

Information Theory · Computer Science 2018-02-14 Tachporn Sanguanpuak , Sudarshan Guruacharya , Ekram Hossain , Dusit Niyato , Nandana Rajatheva , Matti Latva-aho

Collective oscillation of cells in a population has been reported under diverse biological contexts and with vastly different molecular constructs. Could there be common principles similar to those that govern spontaneous oscillation in…

Cell Behavior · Quantitative Biology 2019-07-08 Shou-Wen Wang , Lei-Han Tang

Despite recent molecular technique improvements, biological knowledge remains incomplete. Reasoning on living systems hence implies to integrate heterogeneous and partial informations. Although current investigations successfully focus on…

Quantitative Methods · Quantitative Biology 2009-09-29 Jérémie Bourdon , Damien Eveillard , Samuel Gabillard , Theo Merle

Cell migration in vivo is often guided by chemical signals. Such chemotaxis, such as performed by immune cells migrating to a wound site, is complicated by the complex geometry inside living tissues. In this study, we extend our theoretical…

The behavior of users in relatively predictable, both in terms of the data they request and the wireless channels they observe. In this paper, we consider the statistics of such predictable patterns of the demand and channel jointly across…

Information Theory · Computer Science 2018-06-14 L. Srikar Muppirisetty , John Tadrous , Atilla Eryilmaz , Henk Wymeersch