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Nuclear segmentation and classification is an essential step for computational pathology. TIA lab from Warwick University organized a nuclear segmentation and classification challenge (CoNIC) for H&E stained histopathology images in…

Image and Video Processing · Electrical Eng. & Systems 2022-03-22 Jijun Cheng , Xipeng Pan , Feihu Hou , Bingchao Zhao , Jiatai Lin , Zhenbing Liu , Zaiyi Liu , Chu Han

Stain variation is a phenomenon observed when distinct pathology laboratories stain tissue slides that exhibit similar but not identical color appearance. Due to this color shift between laboratories, convolutional neural networks (CNNs)…

Computer Vision and Pattern Recognition · Computer Science 2020-04-16 David Tellez , Geert Litjens , Peter Bandi , Wouter Bulten , John-Melle Bokhorst , Francesco Ciompi , Jeroen van der Laak

Nucleus segmentation is usually the first step in pathological image analysis tasks. Generalizable nucleus segmentation refers to the problem of training a segmentation model that is robust to domain gaps between the source and target…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Shengcong Chen , Changxing Ding , Dacheng Tao , Hao Chen

Nuclear detection, segmentation and morphometric profiling are essential in helping us further understand the relationship between histology and patient outcome. To drive innovation in this area, we setup a community-wide challenge using…

Computer Vision and Pattern Recognition · Computer Science 2023-03-15 Simon Graham , Quoc Dang Vu , Mostafa Jahanifar , Martin Weigert , Uwe Schmidt , Wenhua Zhang , Jun Zhang , Sen Yang , Jinxi Xiang , Xiyue Wang , Josef Lorenz Rumberger , Elias Baumann , Peter Hirsch , Lihao Liu , Chenyang Hong , Angelica I. Aviles-Rivero , Ayushi Jain , Heeyoung Ahn , Yiyu Hong , Hussam Azzuni , Min Xu , Mohammad Yaqub , Marie-Claire Blache , Benoît Piégu , Bertrand Vernay , Tim Scherr , Moritz Böhland , Katharina Löffler , Jiachen Li , Weiqin Ying , Chixin Wang , Dagmar Kainmueller , Carola-Bibiane Schönlieb , Shuolin Liu , Dhairya Talsania , Yughender Meda , Prakash Mishra , Muhammad Ridzuan , Oliver Neumann , Marcel P. Schilling , Markus Reischl , Ralf Mikut , Banban Huang , Hsiang-Chin Chien , Ching-Ping Wang , Chia-Yen Lee , Hong-Kun Lin , Zaiyi Liu , Xipeng Pan , Chu Han , Jijun Cheng , Muhammad Dawood , Srijay Deshpande , Raja Muhammad Saad Bashir , Adam Shephard , Pedro Costa , João D. Nunes , Aurélio Campilho , Jaime S. Cardoso , Hrishikesh P S , Densen Puthussery , Devika R G , Jiji C , Ye Zhang , Zijie Fang , Zhifan Lin , Yongbing Zhang , Chunhui Lin , Liukun Zhang , Lijian Mao , Min Wu , Vi Thi-Tuong Vo , Soo-Hyung Kim , Taebum Lee , Satoshi Kondo , Satoshi Kasai , Pranay Dumbhare , Vedant Phuse , Yash Dubey , Ankush Jamthikar , Trinh Thi Le Vuong , Jin Tae Kwak , Dorsa Ziaei , Hyun Jung , Tianyi Miao , David Snead , Shan E Ahmed Raza , Fayyaz Minhas , Nasir M. Rajpoot

Nuclei segmentation and classification is the first and most crucial step that is utilized for many different microscopy medical analysis applications. However, it suffers from many issues such as the segmentation of small objects,…

Image and Video Processing · Electrical Eng. & Systems 2022-03-07 Hussam Azzuni , Muhammad Ridzuan , Min Xu , Mohammad Yaqub

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Digital pathology has made significant advances in tumor diagnosis and segmentation, but image variability due to differences in organs, tissue preparation, and acquisition - known as domain shift - limits the effectiveness of current…

Image and Video Processing · Electrical Eng. & Systems 2024-09-23 Ho Heon Kim , Won Chan Jeong , Young Shin Ko , Young Jin Park

Deep learning advances have revolutionized automated digital pathology analysis. However, differences in staining protocols and imaging conditions can introduce significant color variability. In deep learning, such color inconsistency often…

Computer Vision and Pattern Recognition · Computer Science 2025-10-09 Tianyue Xu , Yanlin Wu , Abhai K. Tripathi , Matthew M. Ippolito , Benjamin D. Haeffele

Background and objectives. Domain shift is a generalisation problem of machine learning models that occurs when the data distribution of the training set is different to the data distribution encountered by the model when it is deployed.…

Computer Vision and Pattern Recognition · Computer Science 2022-07-28 Manuel García-Domínguez , César Domínguez , Jónathan Heras , Eloy Mata , Vico Pascual

Color inconsistency is an inevitable challenge in computational pathology, which generally happens because of stain intensity variations or sections scanned by different scanners. It harms the pathological image analysis methods, especially…

Image and Video Processing · Electrical Eng. & Systems 2022-03-01 Bingchao Zhao , Jiatai Lin , Changhong Liang , Zongjian Yi , Xin Chen , Bingbing Li , Weihao Qiu , Danyi Li , Li Liang , Chu Han , Zaiyi Liu

In many modern computer application problems, the classification of image data plays an important role. Among many different supervised machine learning models, convolutional neural networks (CNNs) and linear discriminant analysis (LDA) as…

Computer Vision and Pattern Recognition · Computer Science 2024-11-01 Axel Klawonn , Martin Lanser , Janine Weber

Nuclear segmentation, classification and quantification within Haematoxylin & Eosin stained histology images enables the extraction of interpretable cell-based features that can be used in downstream explainable models in computational…

Computer Vision and Pattern Recognition · Computer Science 2021-11-30 Simon Graham , Mostafa Jahanifar , Quoc Dang Vu , Giorgos Hadjigeorghiou , Thomas Leech , David Snead , Shan E Ahmed Raza , Fayyaz Minhas , Nasir Rajpoot

Annotation scarcity and cross-modality/stain data distribution shifts are two major obstacles hindering the application of deep learning models for nuclei analysis, which holds a broad spectrum of potential applications in digital…

Computer Vision and Pattern Recognition · Computer Science 2024-01-23 Jianan Fan , Dongnan Liu , Hang Chang , Weidong Cai

Stain color variation in histological images, caused by a variety of factors, is a challenge not only for the visual diagnosis of pathologists but also for cell segmentation algorithms. To eliminate the color variation, many stain…

Image and Video Processing · Electrical Eng. & Systems 2022-10-27 Huaqian Wu , Nicolas Souedet , Camille Mabillon , Caroline Jan , Cédric Clouchoux , Thierry Delzescaux

In recent years, deep neural networks (DNNs) have demonstrated remarkable performance in pathology applications, potentially even outperforming expert pathologists due to their ability to learn subtle features from large datasets. One…

Image and Video Processing · Electrical Eng. & Systems 2024-09-16 Siyu , Lin , Haowen Zhou , Richard J. Cote , Mark Watson , Ramaswamy Govindan , Changhuei Yang

Medical image segmentation plays a crucial role in clinical workflows, but domain shift often leads to performance degradation when models are applied to unseen clinical domains. This challenge arises due to variations in imaging…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Yingkai Wang , Yaoyao Zhu , Xiuding Cai , Yuhao Xiao , Haotian Wu , Yu Yao

Convolutional Neural Networks (CNNs) show impressive performance in the standard classification setting where training and testing data are drawn i.i.d. from a given domain. However, CNNs do not readily generalize to new domains with…

Computer Vision and Pattern Recognition · Computer Science 2020-07-13 Nathan Somavarapu , Chih-Yao Ma , Zsolt Kira

The limited ability of Convolutional Neural Networks to generalize to images from previously unseen domains is a major limitation, in particular, for safety-critical clinical tasks such as dermoscopic skin cancer classification. In order to…

Computer Vision and Pattern Recognition · Computer Science 2023-07-04 Katharina Fogelberg , Sireesha Chamarthi , Roman C. Maron , Julia Niebling , Titus J. Brinker

Automatic colorization of gray images with objects of different colors and sizes is challenging due to inter- and intra-object color variation and the small area of the main objects due to extensive backgrounds. The learning process often…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Mrityunjoy Gain , Avi Deb Raha , Rameswar Debnath

In the last years, neural networks have proven to be a powerful framework for various image analysis problems. However, some application domains have specific limitations. Notably, digital pathology is an example of such fields due to…

Computer Vision and Pattern Recognition · Computer Science 2018-02-06 Gleb Makarchuk , Vladimir Kondratenko , Maxim Pisov , Artem Pimkin , Egor Krivov , Mikhail Belyaev
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