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Radiotherapy is used to treat cancer patients by damaging DNA of tumor cells using ionizing radiation. Photons are the most widely used radiation type for therapy, having been put into use soon after the first discovery of X-rays in 1895.…

Optimization and Control · Mathematics 2019-11-20 Roman Levin , Aleksandr Y. Aravkin , Minsun Kim

Fluence map optimization for intensity-modulated radiation therapy planning can be formulated as a large-scale inverse problem with competing objectives and constraints associated with the tumors and organs-at-risk. Unfortunately,…

Optimization and Control · Mathematics 2022-02-17 Kelsey Maass , Minsun Kim , Aleksandr Aravkin

For many applications of pulsed radiation, the time-history of the radiation intensity must be optimized to induce a desired time-history of conditions. This optimization is normally performed using multi-physics simulations of the system.…

Computational Physics · Physics 2019-03-14 Damian C. Swift , George B. Zimmerman

The problem of spatially selective radio-frequency (RF) pulse design in magnetic resonance imaging (MRI) is typically stated in the form of determining, analytically or numerically, RF waveforms to be applied in synchrony with one or more…

Instrumentation and Detectors · Physics 2026-04-28 Seung-Kyun Lee

The problem of optimization of propagation-based phase-contrast imaging setups is considered in the case of projection X-ray imaging and three-dimensional tomography with phase retrieval. For two-dimensional imaging, a simple model for a…

Medical Physics · Physics 2026-03-03 T. E. Gureyev , D. M. Paganin , H. M. Quiney

Accurate dose distribution prediction is crucial in the radiotherapy planning. Although previous methods based on convolutional neural network have shown promising performance, they have the problem of over-smoothing, leading to prediction…

Image and Video Processing · Electrical Eng. & Systems 2024-10-31 Xin Liao , Zhenghao Feng , Jianghong Xiao , Xingchen Peng , Yan Wang

Image optimization problems encompass many applications such as spectral fusion, deblurring, deconvolution, dehazing, matting, reflection removal and image interpolation, among others. With current image sizes in the order of megabytes, it…

Computer Vision and Pattern Recognition · Computer Science 2018-09-13 Majed El Helou , Frederike Dümbgen , Radhakrishna Achanta , Sabine Süsstrunk

Recently, diagnosis, therapy and monitoring of human diseases involve a variety of imaging modalities, such as magnetic resonance imaging(MRI), computed tomography(CT), Ultrasound(US) and Positron-emission tomography(PET) as well as a…

Computer Vision and Pattern Recognition · Computer Science 2018-09-25 Jing Yuan , Aaron Fenster

We propose a system to optimize parametric designs subject to radiation pressure, \ie the effect of light on the motion of objects. This is most relevant in the design of spacecraft, where radiation pressure presents the dominant…

Graphics · Computer Science 2026-05-07 Charles Constant , Elizabeth Bates , Santosh Bhattarai , Marek Ziebart , Tobias Ritschel

In the past decades mathematical optimization has found its way into radiation therapy and has made profound practice changing impact. Today, virtually all advanced treatment delivery methods, such as IMRT, VMAT, tomotherapy, LDR/HDR…

Medical Physics · Physics 2018-10-31 Bram L. Gorissen , Jan Unkelbach , Thomas R. Bortfeld

Infrared and visible image fusion aims to utilize the complementary information from two modalities to generate fused images with prominent targets and rich texture details. Most existing algorithms only perform pixel-level or feature-level…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Kun Hu , Qingle Zhang , Maoxun Yuan , Yitian Zhang

In this work, we propose a new paradigm of iterative model-based reconstruction algorithms for providing real-time solution for zooming-in and refining a region of interest in medical and clinical tomographic images. This algorithmic…

Image and Video Processing · Electrical Eng. & Systems 2025-12-01 Junqi Tang , Guixian Xu , Jinglai Li

The paper presents many facets of medical imaging investigations radiological risks. The total volume of prescribed medical investigations proves a serious lack in monitoring and tracking of the cumulative radiation doses in many health…

Medical Physics · Physics 2015-11-09 Lidia Dobrescu , Gheorghe-Cristian Rădulescu

Functional magnetic resonance imaging (fMRI) technology is popularly used in many fields for studying how the brain reacts to mental stimuli. The identification of optimal fMRI experimental designs is crucial for rendering precise…

Statistics Theory · Mathematics 2015-10-30 Ching-Shui Cheng , Ming-Hung Kao

A realistic computer-simulation of a breast computed tomography (CT) system and subject is constructed. The model is used to investigate the optimal number of views for the scan given a fixed total X-ray fluence. The reconstruction…

In intensity-modulated radiation therapy, optimal intensity distributions of incoming beams are decomposed into linear combinations of leaf openings of a multileaf collimator (segments). In order to avoid inefficient dose delivery, the…

Medical Physics · Physics 2010-09-29 Antje Kiesel , Tobias Gauer

Spatiotemporal fractionation schemes, that is, treatments delivering different dose distributions in different fractions, may lower treatment side effects without compromising tumor control. This is achieved by hypofractionating parts of…

Medical Physics · Physics 2018-02-14 Melissa R. Gaddy , Sercan Yıldız , Jan Unkelbach , Dávid Papp

Radiotherapy planning is a critical aspect of cancer treatment, where the optimal selection of beam directions and dose distributions significantly impacts treatment efficacy and patient outcomes. Traditionally, this process involves…

Medical Physics · Physics 2023-12-05 Keshav Kumar K. , NVSL Narasimham , A. Ramakrishna Prasad

This paper introduces a novel framework for image quality transfer based on conditional flow matching (CFM). Unlike conventional generative models that rely on iterative sampling or adversarial objectives, CFM learns a continuous flow…

Computer Vision and Pattern Recognition · Computer Science 2025-10-15 Huu Tien Nguyen , Ahmed Karam Eldaly

Objective: In this review, we aim to provide an analysis of current cardiac ablation techniques, such as radiofrequency ablation (RF), cryoablation, and pulsed-field ablation (PFA), with a focus on the role of computational modeling in…

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