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Prostate cancer (PCa) is a severe disease among men globally. It is important to identify PCa early and make a precise diagnosis for effective treatment. For PCa diagnosis, Multi-parametric magnetic resonance imaging (mpMRI) emerged as an…
Hepatocellular carcinoma (HCC) is the second most frequent cause of malignancy-related death and is one of the diseases with the highest incidence in the world. Because the liver is the only organ in the human body that is supplied by two…
Pulmonary pathologies are a significant global health concern, often leading to fatal outcomes if not diagnosed and treated promptly. Chest radiography serves as a primary diagnostic tool, but the availability of experienced radiologists…
Spatial arrangement of cells of various types, such as tumor infiltrating lymphocytes and the advancing edge of a tumor, are important features for detecting and characterizing cancers. However, convolutional neural networks (CNNs) do not…
The Quadrant-Slope Index (QSI) method was created in order to detect subtle patterns of organization in tumor images that have metaplastic elements, such as streams of spindle cells [1]. However, metaplastic tumors also have nuclei that may…
Metastatic prostate cancer is one of the most common cancers in men. In the advanced stages of prostate cancer, tumours can metastasise to other tissues in the body, which is fatal. In this thesis, we performed a genetic analysis of…
Automated detection of sclerotic metastases (bone lesions) in Computed Tomography (CT) images has potential to be an important tool in clinical practice and research. State-of-the-art methods show performance of 79% sensitivity or…
Early detection of brain metastases (BM) is one of the determining factors for the successful treatment of patients with cancer; however, the accurate detection of small BM lesions (< 15mm) remains a challenging task. We previously…
This study addresses critical gaps in automated lymphoma segmentation from PET/CT images, focusing on issues often overlooked in existing literature. While deep learning has been applied for lymphoma lesion segmentation, few studies…
Anomaly detection is an emerging approach in digital pathology for its ability to efficiently and effectively utilize data for disease diagnosis. While supervised learning approaches deliver high accuracy, they rely on extensively annotated…
Lung cancer remains one of the leading causes of morbidity and mortality worldwide, making early diagnosis critical for improving therapeutic outcomes and patient prognosis. Computer-aided diagnosis systems, which analyze computed…
Different types of Convolutional Neural Networks (CNNs) have been applied to detect cancerous lung nodules from computed tomography (CT) scans. However, the size of a nodule is very diverse and can range anywhere between 3 and 30…
The early identification of malignant pulmonary nodules is critical for better lung cancer prognosis and less invasive chemo or radio therapies. Nodule malignancy assessment done by radiologists is extremely useful for planning a preventive…
Colorectal liver metastasis is one of most aggressive liver malignancies. While the definition of lesion type based on CT images determines the diagnosis and therapeutic strategy, the discrimination between cancerous and non-cancerous…
Multi-phase computed tomography (CT) scans use contrast agents to highlight different anatomical structures within the body to improve the probability of identifying and detecting anatomical structures of interest and abnormalities such as…
Accurate lymph node (LN) segmentation is critical in radiotherapy treatment and prognosis analysis, but is limited by the need for large annotated datasets. While deep learning-based segmentation foundation models show potential in…
The growth of abnormal cells in the brain's tissue causes brain tumors. Brain tumors are considered one of the most dangerous disorders in children and adults. It develops quickly, and the patient's survival prospects are slim if not…
Image segmentation is a fundamental problem in medical image analysis. In recent years, deep neural networks achieve impressive performances on many medical image segmentation tasks by supervised learning on large manually annotated data.…
Automatic detection of cancer metastasis from whole slide images (WSIs) is a crucial step for following patient staging and prognosis. Recent convolutional neural network based approaches are struggling with the trade-off between accuracy…
Digital pathology and microscopy image analysis are widely employed in the segmentation of digitally scanned IHC slides, primarily to identify cancer and pinpoint regions of interest (ROI) indicative of tumor presence. However, current ROI…