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Histopathological image analysis is an essential process for the discovery of diseases such as cancer. However, it is challenging to train CNN on whole slide images (WSIs) of gigapixel resolution considering the available memory capacity.…

Image and Video Processing · Electrical Eng. & Systems 2019-10-11 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Masashi Fukayama , Akihiko Yoshizawa , Masanobu Kitagawa , Tatsuya Harada

Image instance segmentation is a fundamental research topic in autonomous driving, which is crucial for scene understanding and road safety. Advanced learning-based approaches often rely on the costly 2D mask annotations for training. In…

Computer Vision and Pattern Recognition · Computer Science 2023-01-20 Xiang Li , Junbo Yin , Botian Shi , Yikang Li , Ruigang Yang , Jianbing Shen

In this paper, we develop a new weakly-supervised learning algorithm to learn to segment cancerous regions in histopathology images. Our work is under a multiple instance learning framework (MIL) with a new formulation, deep weak…

Computer Vision and Pattern Recognition · Computer Science 2017-08-30 Zhipeng Jia , Xingyi Huang , Eric I-Chao Chang , Yan Xu

Semantic segmentation is a core computer vision problem, but the high costs of data annotation have hindered its wide application. Weakly-Supervised Semantic Segmentation (WSSS) offers a cost-efficient workaround to extensive labeling in…

Computer Vision and Pattern Recognition · Computer Science 2024-05-13 Elham Ravanbakhsh , Cheng Niu , Yongqing Liang , J. Ramanujam , Xin Li

Classification of gigapixel Whole Slide Images (WSIs) is an important prediction task in the emerging area of computational pathology. There has been a surge of research in deep learning models for WSI classification with clinical…

Computer Vision and Pattern Recognition · Computer Science 2023-05-04 Sajid Javed , Arif Mahmood , Talha Qaiser , Naoufel Werghi , Nasir Rajpoot

Weakly supervised semantic segmentation (WSSS) aims to produce pixel-wise class predictions with only image-level labels for training. To this end, previous methods adopt the common pipeline: they generate pseudo masks from class activation…

Computer Vision and Pattern Recognition · Computer Science 2022-08-09 Sungpil Kho , Pilhyeon Lee , Wonyoung Lee , Minsong Ki , Hyeran Byun

Weakly supervised semantic segmentation (WSSS) in histopathology seeks to reduce annotation cost by learning from image-level labels, yet it remains limited by inter-class homogeneity, intra-class heterogeneity, and the region-shrinkage…

Weakly supervised semantic segmentation (WSSS) trains dense pixel-level segmentation models from partial or coarse annotations such as bounding boxes, scribbles, or image-level tags. While recent work leverages foundation models such as the…

Computer Vision and Pattern Recognition · Computer Science 2026-05-14 Stefano Colamonaco , Andrei-Bogdan Florea , Jaron Maene

The vast majority of semantic segmentation approaches rely on pixel-level annotations that are tedious and time consuming to obtain and suffer from significant inter and intra-expert variability. To address these issues, recent approaches…

Recently, various deep learning methods have shown significant successes in medical image analysis, especially in the detection of cancer metastases in hematoxylin and eosin (H&E) stained whole-slide images (WSIs). However, in order to…

Image and Video Processing · Electrical Eng. & Systems 2023-03-21 Yinsheng He , Xingyu Li

Whole Slide Image (WSI) classification is often formulated as a Multiple Instance Learning (MIL) problem. Recently, Vision-Language Models (VLMs) have demonstrated remarkable performance in WSI classification. However, existing methods…

Computer Vision and Pattern Recognition · Computer Science 2024-04-08 Hao Li , Ying Chen , Yifei Chen , Wenxian Yang , Bowen Ding , Yuchen Han , Liansheng Wang , Rongshan Yu

In this paper, we study weakly-supervised laparoscopic image segmentation with sparse annotations. We introduce a novel Bayesian deep learning approach designed to enhance both the accuracy and interpretability of the model's segmentation,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-14 Zhou Zheng , Yuichiro Hayashi , Masahiro Oda , Takayuki Kitasaka , Kensaku Mori

Obtaining a large amount of labeled data in medical imaging is laborious and time-consuming, especially for histopathology. However, it is much easier and cheaper to get unlabeled data from whole-slide images (WSIs). Semi-supervised…

Image and Video Processing · Electrical Eng. & Systems 2020-08-13 Zeyu Gao , Pargorn Puttapirat , Jiangbo Shi , Chen Li

The expensive fine-grained annotation and data scarcity have become the primary obstacles for the widespread adoption of deep learning-based Whole Slide Images (WSI) classification algorithms in clinical practice. Unlike few-shot learning…

Computer Vision and Pattern Recognition · Computer Science 2024-10-01 Kexue Fu , Xiaoyuan Luo , Linhao Qu , Shuo Wang , Ying Xiong , Ilias Maglogiannis , Longxiang Gao , Manning Wang

Accurate nuclei segmentation in microscopy whole slide images (WSIs) remains challenging due to variability in staining, imaging conditions, and tissue morphology. We propose CellGenNet, a knowledge distillation framework for robust…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Srijan Ray , Bikesh K. Nirala , Jason T. Yustein , Sundaresh Ram

Volumetric lesion segmentation from computed tomography (CT) images is a powerful means to precisely assess multiple time-point lesion/tumor changes. However, because manual 3D segmentation is prohibitively time consuming, current practices…

Computer Vision and Pattern Recognition · Computer Science 2018-07-04 Jinzheng Cai , Youbao Tang , Le Lu , Adam P. Harrison , Ke Yan , Jing Xiao , Lin Yang , Ronald M. Summers

Cell shape analysis is important in biomedical research. Deep learning methods may perform to segment individual cells if they use sufficient training data that the boundary of each cell is annotated. However, it is very time-consuming for…

Image and Video Processing · Electrical Eng. & Systems 2020-02-26 Kazuya Nishimura , Dai Fei Elmer Ker , Ryoma Bise

Whole slide images (WSI) are microscopy images of stained tissue slides routinely prepared for diagnosis and treatment selection in medical practice. WSI are very large (gigapixel size) and complex (made of up to millions of cells). The…

Computer Vision and Pattern Recognition · Computer Science 2022-12-08 Tristan Lazard , Marvin Lerousseau , Etienne Decencière , Thomas Walter

Accurate segmentation of Optical Coherence Tomography (OCT) images is crucial for diagnosing and monitoring retinal diseases. However, the labor-intensive nature of pixel-level annotation limits the scalability of supervised learning for…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Jiaqi Yang , Nitish Mehta , Xiaoling Hu , Chao Chen , Chia-Ling Tsai

Weakly supervised nuclei segmentation is a critical problem for pathological image analysis and greatly benefits the community due to the significant reduction of labeling cost. Adopting point annotations, previous methods mostly rely on…

Image and Video Processing · Electrical Eng. & Systems 2022-02-14 Weizhen Liu , Qian He , Xuming He