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Understanding principles of neurolocomotion requires the synthesis of neural activity, sensory feedback, and biomechanics. The nematode \textit{C. elegans} is an ideal model organism for studying locomotion in an integrated neuromechanical…

Neurons and Cognition · Quantitative Biology 2021-06-08 Carter L. Johnson , Timothy J. Lewis , Robert D. Guy

We analyse the neural dynamics and its relation with the emergent behaviour of a robotic vehicle that is controlled by a neural network numerical simulation based on the nervous system of the nematode Caenorhabditis elegans. The robot…

Neurons and Cognition · Quantitative Biology 2020-11-19 Carlos E. Valencia Urbina , Sergio A. Cannas , Pablo M. Gleiser

We propose an effective way to create interpretable control agents, by re-purposing the function of a biological neural circuit model, to govern simulated and real world reinforcement learning (RL) test-beds. We model the tap-withdrawal…

Neurons and Cognition · Quantitative Biology 2018-03-26 Mathias Lechner , Ramin M. Hasani , Radu Grosu

The cerebrospinal fluid (CSF) constitutes an interface through which chemical cues can reach and modulate the activity of neurons located at the epithelial boundary within the entire nervous system. Here, we investigate the role and…

Neurons and Cognition · Quantitative Biology 2018-12-04 Kevin Fidelin , Lydia Djenoune , Caleb Stokes , Andrew Prendergast , Johanna Gómez , Audrey Baradel , Filippo Del bene , Claire Wyart

Animals adjust their behavioral response to sensory input adaptively depending on past experiences. The flexible brain computation is crucial for survival and is of great interest in neuroscience. The nematode C. elegans modulates its…

Neurons and Cognition · Quantitative Biology 2024-02-26 Kevin S. Chen , Anuj K. Sharma , Jonathan W. Pillow , Andrew M. Leifer

We exploit the reduced space of C. elegans postures to develop a novel tracking algorithm which captures both simple shapes and also self-occluding coils, an important, yet unexplored, component of worm behavior. We apply our algorithm to…

Quantitative Methods · Quantitative Biology 2016-11-01 Onno D Broekmans , Jarlath B Rodgers , William S Ryu , Greg J Stephens

Understanding physical rules underlying collective motions requires perturbation of controllable parameters in self-propelled particles. However, controlling parameters in animals is generally not easy, which makes collective behaviours of…

Biological Physics · Physics 2019-01-31 Takuma Sugi , Hiroshi Ito , Masaki Nishimura , Ken H. Nagai

The nervous system of the nematode soil worm Caenorhabditis elegans exhibits remarkable complexity despite the worm's small size. A general challenge is to better understand the relationship between neural organization and neural activity…

Neurons and Cognition · Quantitative Biology 2020-10-30 Alejandro Morales , Tom Froese

The roundworm C. elegans exhibits robust escape behavior in response to rapidly rising temperature. The behavior lasts for a few seconds, shows history dependence, involves both sensory and motor systems, and is too complicated to model…

Neurons and Cognition · Quantitative Biology 2019-06-19 Bryan C. Daniels , William S. Ryu , Ilya Nemenman

Biological circuits such as neural or gene regulation networks use internal states to map sensory input to an adaptive repertoire of behavior. Characterizing this mapping is a major challenge for systems biology, and though experiments that…

Neurons and Cognition · Quantitative Biology 2022-10-12 Edward D. Lee , Xiaowen Chen , Bryan C. Daniels

We study external, electrical perturbations and their responses in the brain dynamic network of the \textit{Caenorhabditis elegans} soil worm, given by the connectome of its large somatic nervous system. Our analysis is inspired by a…

Neurons and Cognition · Quantitative Biology 2016-02-17 Chris G. Antonopoulos

Caenorhabditis elegans, a free-living soil nematode, propels itself by producing undulatory body motion and displays a rich variety of body shapes and trajectories during its locomotion in complex environments. Here we show that the complex…

Organisms move through the world by changing their shape, and here we explore the mapping from shape space to movements in the nematode C. elegans as it crawls on a planar agar surface. We characterize the statistics of the trajectories…

Neurons and Cognition · Quantitative Biology 2016-01-05 Greg J Stephens , Bethany Johnson-Kerner , William Bialek , William S Ryu

The video showcases how C. elegans worms respond to DC and AC electrical stimulations. Gabel et al (2007) demonstrated that in the presence of DC and low frequency AC fields, worms of stage L2 and larger propel themselves towards the…

Fluid Dynamics · Physics 2015-05-20 Han-Sheng Chuang , David Raizen , Nooreen Dabbish , Haim Bau

An organism's ability to move freely is a fundamental behaviour in the animal kingdom. To understand animal locomotion requires a characterisation of the material properties, as well as the biomechanics and physiology. We present a…

Biological Physics · Physics 2017-02-17 Netta Cohen , Thomas Ranner

{\it Caenorhabditis elegans} nematode worms are the only animals with the known detailed neural connectivity diagram, well characterized genomics, and relatively simple quantifiable behavioral output. With this in mind, many researchers…

Neurons and Cognition · Quantitative Biology 2019-10-17 Jan Karbowski

Dissipative environments are ubiquitous in nature, from microscopic swimmers in low-Reynolds-number fluids to macroscopic animals in frictional media. In this study, motivated by various behaviours of {\it Caenorhabditis elegans} during…

Adaptation and Self-Organizing Systems · Physics 2025-04-15 Kenta Ishimoto , Clément Moreau , Johann Herault

We introduce SIM-CE, an advanced, user-friendly modeling and simulation environment in Simulink for performing multi-scale behavioral analysis of the nervous system of Caenorhabditis elegans (C. elegans). SIM-CE contains an implementation…

Neurons and Cognition · Quantitative Biology 2017-03-28 Ramin M. Hasani , Victoria Beneder , Magdalena Fuchs , David Lung , Radu Grosu

Cyborg in the brain-machine interface field has attracted more attention in recent years. To control a creature via a machine called cyborg method, three stages are considerable: stimulation of neurons, neural response, and the behavioral…

Biological Physics · Physics 2019-05-01 Mohammad Jamali , Yousef Jamali , Mehdi Golshani

A major challenge in analyzing animal behavior is to discover some underlying simplicity in complex motor actions. Here we show that the space of shapes adopted by the nematode C. elegans is surprisingly low dimensional, with just four…

Other Quantitative Biology · Quantitative Biology 2016-01-05 Greg J Stephens , Bethany Johnson-Kerner , William Bialek , William S Ryu