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The early promises of DNA computing to deliver a massively parallel architecture well-suited to computationally hard problems have so far been largely unkept. Indeed, it is probably fair to say that only toy problems have been addressed…

Cryptography and Security · Computer Science 2007-05-23 Olivier Pelletier , Andre Weimerskirch

DNA origami is a widely used method to construct nanostructures by self-assembling designed DNA strands. These structures are often used as "pegboards" for templated assembly of proteins, gold nanoparticles, aptamers, and other molecules,…

Soft Condensed Matter · Physics 2024-11-05 Matthew Sample , Hao Liu , Thong Diep , Michael Matthies , Petr Šulc

We investigate the role of nondeterminism in Winfree's abstract Tile Assembly Model (aTAM), which was conceived to model artificial molecular self-assembling systems constructed from DNA. Of particular practical importance is to find tile…

Computational Complexity · Computer Science 2010-11-29 Nathaniel Bryans , Ehsan Chiniforooshan , David Doty , Lila Kari , Shinnosuke Seki

We investigate the computing power of a restricted class of DNA strand displacement structures: those that are made of double strands with nicks (interruptions) in the top strand. To preserve this structural invariant, we impose…

Logic in Computer Science · Computer Science 2010-06-16 Luca Cardelli

We show that the Tile Assembly Model exhibits a strong notion of universality where the goal is to give a single tile assembly system that simulates the behavior of any other tile assembly system. We give a tile assembly system that is…

Computational Complexity · Computer Science 2016-09-08 David Doty , Jack H. Lutz , Matthew J. Patitz , Scott M. Summers , Damien Woods

We study the computational power of the Full-Tilt model of motion planning, where slidable polyominos are moved maximally around a board by way of a sequence of directional ``tilts.'' We focus on the deterministic scenario in which the…

The objective is to find a Cellular Automata rule that can form a 2D point pattern with a maximum number of points (1-cells). Points are not allowed to touch each other, they have to be separated by 0-cells, and every 0-cell can find at…

Computational Geometry · Computer Science 2022-02-15 Rolf Hoffmann

Winfree's abstract Tile Assembly Model (aTAM) is a model of molecular self-assembly of DNA complexes known as tiles, which float freely in solution and attach one at a time to a growing "seed" assembly based on specific binding sites on…

Computational Complexity · Computer Science 2015-03-17 Ho-Lin Chen , David Doty , Shinnosuke Seki

We study a coarse-graining procedure for quantum cellular automata on hypercubic lattices that consists in grouping neighboring cells into tiles and selecting a subspace within each tile. This is done in such a way that multiple evolution…

Quantum Physics · Physics 2025-06-04 Lorenzo Siro Trezzini , Alessandro Bisio , Paolo Perinotti

Molecular-scale computation is crucial for smart materials and nanoscale devices, yet creating single-molecule systems capable of complex computations remains challenging. We present a theoretical framework for a single-molecule computer…

Statistical Mechanics · Physics 2024-10-01 Zhongmin Zhang , Zhiyue Lu

In a probabilistic cellular automaton in which all local transitions have positive probability, the problem of keeping a bit of information indefinitely is nontrivial, even in an infinite automaton. Still, there is a solution in 2…

Probability · Mathematics 2024-01-26 Peter Gacs

DNA origami consists of a long scaffold strand and short staple strands that self-assemble into a target 2D or 3D shape. It is a widely used construct in nucleic acid nanotechnology, offering a cost-effective way to design and create…

Soft Condensed Matter · Physics 2024-09-23 Sarah Haggenmueller , Michael Matthies , Matthew Sample , Petr Šulc

DNA nanostructures are made using synthetic DNA strands, the sequences of which are designed such that they will self-assemble into the desired form by hybridization of complementary domains. Various structures and devices have been…

Biological Physics · Physics 2015-06-02 Katherine E. Dunn

One-dimensional cellular automata are discrete dynamical systems that operate on an infinite lattice of sites and are characterized by the locality and uniformity of their update rule. Permutations of the state set and isometric…

Cellular Automata and Lattice Gases · Physics 2025-12-10 Martin Schaller , Karl Svozil

Molecular electronics and other technologies whose components comprise individual molecules have been pursued for half a century because the molecular scale represents the limit of miniaturisation of objects whose structure is tuneable for…

In this paper we propose a research programme for getting structural characterisations for 2-dimensional languages generated by self-assembling tiles. This is part of a larger programme on getting a formal foundation of parallel,…

Formal Languages and Automata Theory · Computer Science 2015-06-19 Gheorghe Stefanescu

DNA nanotechnology allows for the realization of complex nanoarchitectures in which the spatial arrangements of different constituents and most functions can be enabled by DNA. When optically active components are integrated in such…

Biological Physics · Physics 2021-05-10 Pengfei Zhan , Steffen Both , Thomas Weiss , Na Liu

DNA strand displacement systems have proven themselves to be fertile substrates for the design of programmable molecular machinery and circuitry. Domain-level reaction enumerators provide the foundations for molecular programming languages…

Computational Engineering, Finance, and Science · Computer Science 2020-06-05 Casey Grun , Karthik Sarma , Brian Wolfe , Seung Woo Shin , Erik Winfree

Recent advancements in microbiology have motivated the study of the production of nanostructures with applications such as biomedical computing and molecular robotics. One way to construct these structures is to construct branched DNA…

As a mathematical model of self-assembling systems, Winfree's abstract Tile Assembly Model (aTAM) is a remarkable platform for studying the behaviors and powers of self-assembling systems. Capable of Turing universal computation, the aTAM…

Computational Geometry · Computer Science 2016-08-11 Jacob Hendricks , Matthew J. Patitz , Trent A. Rogers