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Transformer-based masked language models such as BERT, trained on general corpora, have shown impressive performance on downstream tasks. It has also been demonstrated that the downstream task performance of such models can be improved by…

Computation and Language · Computer Science 2023-05-04 Zhi Hong , Aswathy Ajith , Gregory Pauloski , Eamon Duede , Kyle Chard , Ian Foster

Recent work has demonstrated substantial gains on many NLP tasks and benchmarks by pre-training on a large corpus of text followed by fine-tuning on a specific task. While typically task-agnostic in architecture, this method still requires…

Large language models (LLMs) often lack specialized knowledge for complex bioinformatics applications. We present a reproducible pipeline for fine-tuning LLMs on specialized bioinformatics data, demonstrated through two use cases: PRSGPT,…

Computation and Language · Computer Science 2026-01-21 Muhammad Muneeb , David B. Ascher

The exponential growth of online textual content across diverse domains has necessitated advanced methods for automated text classification. Large Language Models (LLMs) based on transformer architectures have shown significant success in…

Computation and Language · Computer Science 2025-09-09 Zhyar Rzgar K Rostam , Gábor Kertész

Foundation models and their checkpoints have significantly advanced deep learning, boosting performance across various applications. However, fine-tuned models often struggle outside their specific domains and exhibit considerable…

Fine-tuning pre-trained generative language models to down-stream language generation tasks has shown promising results. However, this comes with the cost of having a single, large model for each task, which is not ideal in low-memory/power…

Computation and Language · Computer Science 2020-09-22 Zhaojiang Lin , Andrea Madotto , Pascale Fung

Artificial intelligence (AI) is widely deployed to solve problems related to marketing attribution and budget optimization. However, AI models can be quite complex, and it can be difficult to understand model workings and insights without…

Computation and Language · Computer Science 2024-04-23 Yilin Gao , Sai Kumar Arava , Yancheng Li , James W. Snyder

Fine-tuning and inference with large Language Models (LM) are generally known to be expensive. Parameter-efficient fine-tuning over pretrained LMs reduces training memory by updating a small number of LM parameters but does not improve…

Computation and Language · Computer Science 2024-06-05 Bowen Zhao , Hannaneh Hajishirzi , Qingqing Cao

The use of large language models (LLMs) is becoming increasingly widespread among software developers. However, privacy and computational requirements are problematic with commercial solutions and the use of LLMs. In this work, we focus on…

Software Engineering · Computer Science 2025-06-17 Marko Hostnik , Marko Robnik-Šikonja

Large language models are trained in two stages: (1) unsupervised pretraining from raw text, to learn general-purpose representations, and (2) large scale instruction tuning and reinforcement learning, to better align to end tasks and user…

Computation and Language · Computer Science 2023-05-22 Chunting Zhou , Pengfei Liu , Puxin Xu , Srini Iyer , Jiao Sun , Yuning Mao , Xuezhe Ma , Avia Efrat , Ping Yu , Lili Yu , Susan Zhang , Gargi Ghosh , Mike Lewis , Luke Zettlemoyer , Omer Levy

The fine-tuning of Large Language Models (LLMs) has enabled them to recently achieve milestones in natural language processing applications. The emergence of ever larger LLMs has paved the way for more efficient fine-tuning methods. Among…

Computation and Language · Computer Science 2024-02-01 Christophe Tribes , Sacha Benarroch-Lelong , Peng Lu , Ivan Kobyzev

While protein language models (pLMs) have transformed biological research, the scaling laws governing their improvement remain underexplored. By adapting methodologies from NLP scaling laws, we investigated the optimal ratio between model…

Biomolecules · Quantitative Biology 2024-06-27 Yaiza Serrano , Álvaro Ciudad , Alexis Molina

Fine-tuning and testing a multilingual large language model is expensive and challenging for low-resource languages (LRLs). While previous studies have predicted the performance of natural language processing (NLP) tasks using machine…

Large language models are usually fine-tuned to align with human preferences. However, fine-tuning a large language model can be challenging. In this work, we introduce $\textit{weak-to-strong search}$, framing the alignment of a large…

Computation and Language · Computer Science 2024-11-20 Zhanhui Zhou , Zhixuan Liu , Jie Liu , Zhichen Dong , Chao Yang , Yu Qiao

Pretrained language models like BERT and T5 serve as crucial backbone encoders for dense retrieval. However, these models often exhibit limited generalization capabilities and face challenges in improving in domain accuracy. Recent research…

Computation and Language · Computer Science 2024-08-26 Kun Luo , Minghao Qin , Zheng Liu , Shitao Xiao , Jun Zhao , Kang Liu

Phenotype-driven gene prioritization is a critical process in the diagnosis of rare genetic disorders for identifying and ranking potential disease-causing genes based on observed physical traits or phenotypes. While traditional approaches…

Quantitative Methods · Quantitative Biology 2024-04-04 Junyoung Kim , Jingye Yang , Kai Wang , Chunhua Weng , Cong Liu

Large language models are deep learning models with a large number of parameters. The models made noticeable progress on a large number of tasks, and as a consequence allowing them to serve as valuable and versatile tools for a diverse…

Software Engineering · Computer Science 2023-04-11 Maxim Vidgof , Stefan Bachhofner , Jan Mendling

The emergence of Large Language Models (LLMs) has fundamentally transformed natural language processing, making them indispensable across domains ranging from conversational systems to scientific exploration. However, their pre-trained…

High-quality pretraining data is the fossil fuel of large language models (LLMs), yet its reserves are running low for frontier models. In this paper, we introduce RePro, a novel web recycling method that trains a relatively small LM with…

Computation and Language · Computer Science 2025-10-15 Zichun Yu , Chenyan Xiong

To enhance the performance of large language models (LLMs) in biomedical natural language processing (BioNLP) by introducing a domain-specific instruction dataset and examining its impact when combined with multi-task learning principles.…

Computation and Language · Computer Science 2024-06-10 Hieu Tran , Zhichao Yang , Zonghai Yao , Hong Yu