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In recent years, following FAIR and open data principles, the number of available big data including biomedical data has been increased exponentially. In order to extract knowledge, these data should be curated, integrated, and semantically…

Databases · Computer Science 2018-11-06 Samaneh Jozashoori , Tatiana Novikova , Maria-Esther Vidal

Knowledge graphs (KGs) have emerged as a powerful framework for representing and integrating complex biomedical information. However, assembling KGs from diverse sources remains a significant challenge in several aspects, including entity…

Machine Learning · Computer Science 2023-10-10 Yijia Xiao , Dylan Steinecke , Alexander Russell Pelletier , Yushi Bai , Peipei Ping , Wei Wang

Background. In the last decades, several life science resources have structured data using the same framework and made these accessible using the same query language to facilitate interoperability. Knowledge graphs have seen increased…

Networks provide a meaningful way to represent and analyze complex biological information, but the methodological details of network-based tools are often described for a technical audience. Graphery is a hands-on tutorial webserver…

Molecular Networks · Quantitative Biology 2024-02-19 Heyuan Zeng , Jinbiao Zhang , Gabriel A. Preising , Tobias Rubel , Pramesh Singh , Anna Ritz

Knowledge Graph Completion has been increasingly adopted as a useful method for helping address several tasks in biomedical research, such as drug repurposing or drug-target identification. To that end, a variety of datasets and Knowledge…

Machine Learning · Computer Science 2025-11-07 Alberto Cattaneo , Stephen Bonner , Thomas Martynec , Edward Morrissey , Carlo Luschi , Ian P Barrett , Daniel Justus

Previous approaches for automatic lay summarisation are exclusively reliant on the source article that, given it is written for a technical audience (e.g., researchers), is unlikely to explicitly define all technical concepts or state all…

Computation and Language · Computer Science 2023-10-25 Tomas Goldsack , Zhihao Zhang , Chen Tang , Carolina Scarton , Chenghua Lin

Decisions suggested by improperly designed software systems might be prone to discriminate against people based on protected characteristics, such as gender and ethnicity. Previous studies attribute such undesired behavior to flaws in…

Software Engineering · Computer Science 2025-09-26 Qusai Ramadan , Jukka Ruohonen , Abhishek Tiwari , Adam Alami , Zeyd Boukhers

The real-world implementation of federated learning is complex and requires research and development actions at the crossroad between different domains ranging from data science, to software programming, networking, and security. While…

Biomedical challenges have become the de facto standard for benchmarking biomedical image analysis algorithms. While the number of challenges is steadily increasing, surprisingly little effort has been invested in ensuring high quality…

Computer Vision and Pattern Recognition · Computer Science 2019-12-06 Manuel Wiesenfarth , Annika Reinke , Bennett A. Landman , Manuel Jorge Cardoso , Lena Maier-Hein , Annette Kopp-Schneider

Biomedical research increasingly relies on heterogeneous, high-dimensional datasets, yet effective visualization remains hindered by fragmented code resources, steep programming barriers, and limited domain-specific guidance. Bizard is an…

Knowledge graphs (KGs) are a powerful approach for integrating heterogeneous data and making inferences in biology and many other domains, but a coherent solution for constructing, exchanging, and facilitating the downstream use of…

Navigating and visualizing multilayered knowledge graphs remains a challenging, unresolved problem in information systems design. Building on our earlier study, which engaged end users in both the design and population of a domain-specific…

Human-Computer Interaction · Computer Science 2025-05-05 Stanislava Gardasevic , Manika Lamba , Jasmine S. Malone

We introduce an approach to discovery informatics that uses so called knowledge graphs as the essential representation structure. Knowledge graph is an umbrella term that subsumes various approaches to tractable representation of large…

Artificial Intelligence · Computer Science 2015-04-29 Vit Novacek

Knowledge graphs are an efficient method for representing and connecting information across various concepts, useful in reasoning, question answering, and knowledge base completion tasks. They organize data by linking points, enabling…

Artificial Intelligence · Computer Science 2025-02-25 Saher Mohamed , Kirollos Farah , Abdelrahman Lotfy , Kareem Rizk , Abdelrahman Saeed , Shahenda Mohamed , Ghada Khouriba , Tamer Arafa

Knowledge graphs and ontologies provide promising technical solutions for implementing the FAIR Principles for Findable, Accessible, Interoperable, and Reusable data and metadata. However, they also come with their own challenges. Nine such…

Databases · Computer Science 2023-04-19 Lars Vogt , Marcel Konrad , Manuel Prinz

In the age of big data, it is important for primary research data to follow the FAIR principles of findability, accessibility, interoperability, and reusability. Data harmonization enhances interoperability and reusability by aligning…

Databases · Computer Science 2025-03-26 Jimmy K. Yu , Marcos Martínez-Romero , Matthew Horridge , Mete U. Akdogan , Mark A. Musen

The FAIR (Findable, Accessible, Interoperable, and Reusable) data principles [1] promote the interoperability of scientific data by encouraging the use of persistent identifiers, standardized vocabularies, and formal metadata structures.…

In the rapidly evolving field of bioimaging, the integration and orchestration of Findable, Accessible, Interoperable, and Reusable (FAIR) image analysis workflows remains a challenge. We introduce BIOMERO, a bridge connecting OMERO, a…

Software Engineering · Computer Science 2024-07-26 Torec T. Luik , Rodrigo Rosas-Bertolini , Eric A. J. Reits , Ron A. Hoebe , Przemek M. Krawczyk

Precision medicine and health requires the characterization and phenotyping of biological systems and patient datasets using a variety of data formats. This scenario mandates the centralization of various tools and resources in a unified…