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Deep brain stimulation (DBS) can alleviate the movement disorders like Parkinson's disease (PD). Indeed, it is known that aberrant beta (13-30Hz)oscillations and the loss of dopaminergic neurons in the basal ganglia-thalamus (BGTH) and…

Neurons and Cognition · Quantitative Biology 2021-12-07 Hina Shaheen , Roderick Melnik

Multiscale modelling presents a multifaceted perspective into understanding the mechanisms of the brain and how neurodegenerative disorders like Parkinson's disease (PD) manifest and evolve over time. In this study, we propose a novel…

Neurons and Cognition · Quantitative Biology 2025-09-18 Aaron Herrera , Hina Shaheen

Reinforcement learning (RL) is a promising approach for deriving control policies for complex systems. As we show in two control problems, the derived policies from using the Proximal Policy Optimization (PPO) and Deep Q-Network (DQN)…

Machine Learning · Computer Science 2022-04-05 Jan de Priester , Ricardo G. Sanfelice , Nathan van de Wouw

Deep Brain Stimulation (DBS) is an effective treatment for Parkinson's disease, but conventional fixed-parameter stimulation can reduce battery life and cause side effects while failing to adapt to changing neural dynamics. Recent…

Our aim is to establish a framework where reinforcement learning (RL) of optimizing interventions retrospectively allows us a regulatory compliant pathway to prospective clinical testing of the learned policies in a clinical deployment. We…

Machine Learning · Computer Science 2020-03-20 Luchen Li , Ignacio Albert-Smet , Aldo A. Faisal

This study considers multiple reconfigurable intelligent surfaces (RISs)-aided multiuser downlink systems with the goal of jointly optimizing the transmitter precoding and RIS phase shift matrix to maximize spectrum efficiency. Unlike prior…

Information Theory · Computer Science 2025-10-01 Po-Heng Chou , Bo-Ren Zheng , Wan-Jen Huang , Walid Saad , Yu Tsao , Ronald Y. Chang

Deep reinforcement learning (DRL) algorithms have the potential to provide new insights into psychiatric disorders. Here we create a DRL model of schizophrenia: a complex psychotic disorder characterized by anhedonia, avoidance, temporal…

Neurons and Cognition · Quantitative Biology 2025-10-30 Xena Al-Hejji , Santina Duarte , Jose Guillermo Gomez Castro , Edgar Bermudez Contreras , Eric Chalmers

Deep reinforcement learning (DRL) algorithms can suffer from modeling errors between the simulation and the real world. Many studies use adversarial learning to generate perturbation during training process to model the discrepancy and…

Machine Learning · Computer Science 2024-05-21 Qianmei Liu , Yufei Kuang , Jie Wang

Training a deep neural network to maximize a target objective has become the standard recipe for successful machine learning over the last decade. These networks can be optimized with supervised learning, if the target objective is…

Machine Learning · Computer Science 2025-05-12 Bernhard Jaeger , Andreas Geiger

Reinforcement Learning (RL) provides a powerful framework for decision-making in complex environments. However, implementing RL in hardware-efficient and bio-inspired ways remains a challenge. This paper presents a novel Spiking Neural…

Neural and Evolutionary Computing · Computer Science 2023-08-09 Sergio F. Chevtchenko , Yeshwanth Bethi , Teresa B. Ludermir , Saeed Afshar

This work proposes a unified control architecture that couples a Reinforcement Learning (RL)-driven controller with a disturbance-rejection Extended State Observer (ESO), complemented by an Event-Triggered Mechanism (ETM) to limit…

Optimization and Control · Mathematics 2026-01-01 Ningwei Bai , Chi Pui Chan , Qichen Yin , Tengyang Gong , Yunda Yan , Zezhi Tang

Reinforcement learning (RL) training is inherently unstable due to factors such as moving targets and high gradient variance. Reinforcement Learning from Human Feedback (RLHF) and Reinforcement Learning from AI Feedback (RLAIF) can…

Machine Learning · Computer Science 2025-06-24 Ju-Seung Byun , Andrew Perrault

We study constrained reinforcement learning (CRL) from a novel perspective by setting constraints directly on state density functions, rather than the value functions considered by previous works. State density has a clear physical and…

Machine Learning · Computer Science 2021-06-25 Zengyi Qin , Yuxiao Chen , Chuchu Fan

Deep Reinforcement Learning (DRL) has achieved remarkable advances in sequential decision tasks. However, recent works have revealed that DRL agents are susceptible to slight perturbations in observations. This vulnerability raises concerns…

Machine Learning · Computer Science 2023-12-15 Buqing Nie , Jingtian Ji , Yangqing Fu , Yue Gao

Reinforcement learning (RL) in continuous state-action spaces remains challenging in scientific computing due to poor sample efficiency and lack of pathwise physical consistency. We introduce Differential Reinforcement Learning…

Machine Learning · Computer Science 2026-02-06 Minh Nguyen , Chandrajit Bajaj

The ability to direct a Probabilistic Boolean Network (PBN) to a desired state is important to applications such as targeted therapeutics in cancer biology. Reinforcement Learning (RL) has been proposed as a framework that solves a…

Machine Learning · Computer Science 2022-10-26 Sotiris Moschoyiannis , Evangelos Chatzaroulas , Vytenis Sliogeris , Yuhu Wu

This paper investigates the so-called reward-balancing methods, a novel class of algorithms for solving discounted-return reinforcement learning (RL) problems. These methods consist of iteratively adjusting the reward function to transform…

Optimization and Control · Mathematics 2026-04-23 Simone Baroncini , Bahman Gharesifard , Giuseppe Notarstefano

Dynamical decoupling seeks to mitigate phase decoherence in qubits by applying a carefully designed sequence of effectively instantaneous electromagnetic pulses. Although analytic solutions exist for pulse timings that are optimal under…

Quantum Physics · Physics 2025-12-17 Charles Marrder , Shuo Sun , Murray J. Holland

Neurons in the brain communicate with each other through discrete action spikes as opposed to continuous signal transmission in artificial neural networks. Therefore, the traditional techniques for optimization of parameters in neural…

Machine Learning · Computer Science 2020-05-13 Sneha Aenugu

Deep reinforcement learning (DRL) has attracted much attention as an approach to solve optimal control problems without mathematical models of systems. On the other hand, in general, constraints may be imposed on optimal control problems.…

Machine Learning · Statistics 2022-11-22 Junya Ikemoto , Toshimitsu Ushio