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Identifying differences in networks has become a canonical problem in many biological applications. Here, we focus on testing whether two Gaussian graphical models are the same. Existing methods try to accomplish this goal by either…

Methodology · Statistics 2019-10-01 Sen Zhao , Stephen Ottinger , Suzanne Peck , Christine Mac Donald , Ali Shojaie

Conformal prediction provides prediction sets with finite-sample marginal coverage, but many applications require coverage guarantees that adapt to individual test points, a subpopulation, or a structural component of the data. Existing…

Methodology · Statistics 2026-05-27 Yinjie Min , Liuhua Peng , Changliang Zou

We propose a frequentist testing procedure that maintains a defined coverage and is optimal in the sense that it gives maximal power to detect deviations from a null hypothesis when the alternative to the null hypothesis is sampled from a…

Applications · Statistics 2020-07-07 Christian Bartels , Johanna Mielke , Ekkehard Glimm

We investigate one/two-sample mean tests for high-dimensional compositional data when the number of variables is comparable with the sample size, as commonly encountered in microbiome research. Existing methods mainly focus on max-type test…

Statistics Theory · Mathematics 2024-04-15 Qianqian Jiang , Wenbo Li , Zeng Li

The discrimination of quantum states is a central problem in quantum information science and technology. Meanwhile, partial post-selection has emerged as a valuable tool for quantum state engineering. In this work, we bring these two areas…

Quantum Physics · Physics 2026-04-14 Qipeng Qian , Christos N. Gagatsos

We propose a general new method, the conditional permutation test, for testing the conditional independence of variables $X$ and $Y$ given a potentially high-dimensional random vector $Z$ that may contain confounding factors. The proposed…

Methodology · Statistics 2019-05-08 Thomas B. Berrett , Yi Wang , Rina Foygel Barber , Richard J. Samworth

In this paper, we investigate the impact of high-dimensional Principal Component (PC) adjustments on inferring the effects of variables on outcomes, with a focus on applications in genetic association studies where PC adjustment is commonly…

Statistics Theory · Mathematics 2025-06-30 Sohom Bhattacharya , Rounak Dey , Rajarshi Mukherjee

Linear principal component analysis (PCA) can be extended to a nonlinear PCA by using artificial neural networks. But the benefit of curved components requires a careful control of the model complexity. Moreover, standard techniques for…

Machine Learning · Computer Science 2012-04-04 Matthias Scholz

We discuss the so-called "simplifying assumption" of conditional copulas in a general framework. We introduce several tests of the latter assumption for non- and semiparametric copula models. Some related test procedures based on…

Statistics Theory · Mathematics 2017-05-05 Alexis Derumigny , Jean-David Fermanian

Proximal causal inference is a recently proposed framework for evaluating causal effects in the presence of unmeasured confounding. For point identification of causal effects, it leverages a pair of so-called treatment and outcome…

Methodology · Statistics 2024-01-30 AmirEmad Ghassami , Ilya Shpitser , Eric Tchetgen Tchetgen

The partial correlation coefficient is a commonly used measure to assess the conditional dependence between two random variables. We provide a thorough explanation of the partial copula, which is a natural generalization of the partial…

Methodology · Statistics 2017-06-13 Fabian Spanhel , Malte S. Kurz

In this paper, we introduce a flexible and widely applicable nonparametric entropy-based testing procedure that can be used to assess the validity of simple hypotheses about a specific parametric population distribution. The testing…

Econometrics · Economics 2022-01-19 Ron Mittelhammer , George Judge , Miguel Henry

In this paper we have updated the hypothesis testing framework by drawing upon modern computational power and classification models from machine learning. We show that a simple classification algorithm such as a boosted decision stump can…

Econometrics · Economics 2021-03-03 Gary Cornwall , Jeff Chen , Beau Sauley

Most causal inference algorithms in the literature (e.g., Pearl (2000), Spirtes et al. (2000), Heckerman et al. (1999)) exploit an assumption usually referred to as the causal Faithfulness or Stability condition. In this paper, we highlight…

Artificial Intelligence · Computer Science 2012-07-02 Joseph Ramsey , Jiji Zhang , Peter L. Spirtes

In this paper, we revisit the notion of partial copula, originally introduced to test conditional independence, highlighting its capability to represent the dependence between two random variables after removing their dependence with a…

Methodology · Statistics 2026-05-26 Vinícius Litvinoff Justus , Felipe Fontana Vieira

Randomization tests allow simple and unambiguous tests of null hypotheses, by comparing observed data to a null ensemble in which experimentally-controlled variables are randomly resampled. In behavioral and neuroscience experiments,…

Methodology · Statistics 2023-11-08 Kenneth D. Harris , Kevin J. Miller

In the era of fast-paced precision medicine, observational studies play a major role in properly evaluating new treatments in clinical practice. Yet, unobserved confounding can significantly compromise causal conclusions drawn from…

Machine Learning · Statistics 2026-03-20 Piersilvio De Bartolomeis , Javier Abad , Konstantin Donhauser , Fanny Yang

Statistical hypothesis tests typically use prespecified sample sizes, yet data often arrive sequentially. Interim analyses invalidate classical error guarantees, while existing sequential methods require rigid testing preschedules or incur…

Methodology · Statistics 2026-02-17 Chris Holmes , Stephen Walker

The Cauchy combination test (CCT) is widely used because it gives a closed-form combined $p$-value and is known to be asymptotically valid as the nominal level $\alpha\downarrow0$ under broad dependence structures. We study a different…

Statistics Theory · Mathematics 2026-03-25 Hirofumi Ota

For a general class of atomistic-to-continuum coupling methods, coupling multi-body interatomic potentials with a P1-finite element discretisation of Cauchy--Born nonlinear elasticity, this paper adresses the question whether patch test…

Numerical Analysis · Mathematics 2011-03-16 Christoph Ortner