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The black-box nature of artificial intelligence (AI) models has been the source of many concerns in their use for critical applications. Explainable Artificial Intelligence (XAI) is a rapidly growing research field that aims to create…

Cryptography and Security · Computer Science 2023-06-13 Gaith Rjoub , Jamal Bentahar , Omar Abdel Wahab , Rabeb Mizouni , Alyssa Song , Robin Cohen , Hadi Otrok , Azzam Mourad

Explainable artificial intelligence (XAI) is essential for enabling clinical users to get informed decision support from AI and comply with evidence-based medical practice. Applying XAI in clinical settings requires proper evaluation…

Machine Learning · Computer Science 2022-12-09 Weina Jin , Xiaoxiao Li , Mostafa Fatehi , Ghassan Hamarneh

Nowadays Artificial Intelligence (AI) has become a fundamental component of healthcare applications, both clinical and remote, but the best performing AI systems are often too complex to be self-explaining. Explainable AI (XAI) techniques…

Machine Learning · Computer Science 2022-09-15 Flavio Di Martino , Franca Delmastro

This study explores the integration of multiple Explainable AI (XAI) techniques to enhance the interpretability of deep learning models for brain tumour detection. A custom Convolutional Neural Network (CNN) was developed and trained on the…

Artificial Intelligence · Computer Science 2026-02-06 Patrick McGonagle , William Farrelly , Kevin Curran

The application of deep learning in medical imaging has significantly advanced diagnostic capabilities, enhancing both accuracy and efficiency. Despite these benefits, the lack of transparency in these AI models, often termed "black boxes,"…

Computer Vision and Pattern Recognition · Computer Science 2024-09-23 Eleonora Beatrice Rossi , Eleonora Lopez , Danilo Comminiello

The shift from symbolic AI systems to black-box, sub-symbolic, and statistical ones has motivated a rapid increase in the interest toward explainable AI (XAI), i.e. approaches to make black-box AI systems explainable to human decision…

Artificial Intelligence · Computer Science 2022-10-28 Federico Cabitza , Matteo Cameli , Andrea Campagner , Chiara Natali , Luca Ronzio

The increasing complexity of Artificial Intelligence models poses challenges to interpretability, particularly in the healthcare sector. This study investigates the impact of deep learning model complexity and Explainable AI (XAI) efficacy,…

Computer Vision and Pattern Recognition · Computer Science 2024-10-08 Mateusz Cedro , Marcin Chlebus

Explainable Artificial Intelligence (XAI) methods are typically deployed to explain and debug black-box machine learning models. However, most proposed XAI methods are black-boxes themselves and designed for images. Thus, they rely on…

Machine Learning · Computer Science 2019-09-18 Udo Schlegel , Hiba Arnout , Mennatallah El-Assady , Daniela Oelke , Daniel A. Keim

Large Language Models (LLMs) have played a pivotal role in advancing Artificial Intelligence (AI). However, despite their achievements, LLMs often struggle to explain their decision-making processes, making them a 'black box' and presenting…

Computation and Language · Computer Science 2025-06-30 Avash Palikhe , Zhenyu Yu , Zichong Wang , Wenbin Zhang

The complex nature of disease mechanisms and the variability of patient symptoms pose significant challenges in developing effective diagnostic tools. Although machine learning (ML) has made substantial advances in medical diagnosis, the…

Although modern machine learning and deep learning methods allow for complex and in-depth data analytics, the predictive models generated by these methods are often highly complex, and lack transparency. Explainable AI (XAI) methods are…

Machine Learning · Computer Science 2021-06-17 Mythreyi Velmurugan , Chun Ouyang , Catarina Moreira , Renuka Sindhgatta

eXplainable Artificial Intelligence (XAI) is a rapidly progressing field of machine learning, aiming to unravel the predictions of complex models. XAI is especially required in sensitive applications, e.g. in health care, when diagnosis,…

Artificial Intelligence · Computer Science 2023-09-13 Alena Kalyakulina , Igor Yusipov , Alexey Moskalev , Claudio Franceschi , Mikhail Ivanchenko

Artificial intelligence (AI), particularly machine learning and deep learning models, has significantly impacted bioinformatics research by offering powerful tools for analyzing complex biological data. However, the lack of interpretability…

Artificial Intelligence · Computer Science 2023-12-12 Zhongliang Zhou , Mengxuan Hu , Mariah Salcedo , Nathan Gravel , Wayland Yeung , Aarya Venkat , Dongliang Guo , Jielu Zhang , Natarajan Kannan , Sheng Li

A large set of the explainable Artificial Intelligence (XAI) literature is emerging on feature relevance techniques to explain a deep neural network (DNN) output or explaining models that ingest image source data. However, assessing how XAI…

Artificial Intelligence · Computer Science 2020-12-21 Alexandre Heuillet , Fabien Couthouis , Natalia Díaz-Rodríguez

The past decade has seen significant progress in artificial intelligence (AI), which has resulted in algorithms being adopted for resolving a variety of problems. However, this success has been met by increasing model complexity and…

Machine Learning · Computer Science 2021-11-15 Waddah Saeed , Christian Omlin

Neural Networks are ubiquitous in high energy physics research. However, these highly nonlinear parameterized functions are treated as \textit{black boxes}- whose inner workings to convey information and build the desired input-output…

High Energy Physics - Experiment · Physics 2022-06-15 Mark S. Neubauer , Avik Roy

Nowadays, deep neural networks are widely used in a variety of fields that have a direct impact on society. Although those models typically show outstanding performance, they have been used for a long time as black boxes. To address this,…

Machine Learning · Computer Science 2022-10-11 Huawei Sun , Lorenzo Servadei , Hao Feng , Michael Stephan , Robert Wille , Avik Santra

Advancements in high-throughput technologies have led to a shift from traditional hypothesis-driven methodologies to data-driven approaches. Multi-omics refers to the integrative analysis of data derived from multiple 'omes', such as…

Genomics · Quantitative Biology 2024-10-17 Ahmad Hussein , Mukesh Prasad , Ali Braytee

Deep learning techniques have revolutionized image classification by mimicking human cognition and automating complex decision-making processes. However, the deployment of AI systems in the wild, especially in high-security domains such as…

Computer Vision and Pattern Recognition · Computer Science 2024-09-24 Purushothaman Natarajan , Athira Nambiar

Indecipherable black boxes are common in machine learning (ML), but applications increasingly require explainable artificial intelligence (XAI). The core of XAI is to establish transparent and interpretable data-driven algorithms. This work…

Optimization and Control · Mathematics 2023-06-13 Howard Heaton , Samy Wu Fung
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