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The backpropagation algorithm has experienced remarkable success in training large-scale artificial neural networks; however, its biological plausibility has been strongly criticized, and it remains an open question whether the brain…

Neural and Evolutionary Computing · Computer Science 2026-03-27 Bariscan Bozkurt , Cengiz Pehlevan , Alper T Erdogan

Deep learning has redefined the field of artificial intelligence (AI) thanks to the rise of artificial neural networks, which are architectures inspired by their neurological counterpart in the brain. Through the years, this dualism between…

Machine Learning · Computer Science 2023-02-21 Tommaso Salvatori , Yuhang Song , Thomas Lukasiewicz , Rafal Bogacz , Zhenghua Xu

Ongoing studies have identified similarities between neural representations in biological networks and in deep artificial neural networks. This has led to renewed interest in developing analogies between the backpropagation learning…

Neural and Evolutionary Computing · Computer Science 2019-06-11 Theodore H. Moskovitz , Ashok Litwin-Kumar , L. F. Abbott

Supervised learning in artificial neural networks typically relies on backpropagation, where the weights are updated based on the error-function gradients and sequentially propagated from the output layer to the input layer. Although this…

Neural and Evolutionary Computing · Computer Science 2023-06-06 Giorgia Dellaferrera , Gabriel Kreiman

Interest in biologically inspired alternatives to backpropagation is driven by the desire to both advance connections between deep learning and neuroscience and address backpropagation's shortcomings on tasks such as online, continual…

Neural and Evolutionary Computing · Computer Science 2020-06-18 Jack Lindsey , Ashok Litwin-Kumar

The ability to sequentially learn multiple tasks without forgetting is a key skill of biological brains, whereas it represents a major challenge to the field of deep learning. To avoid catastrophic forgetting, various continual learning…

Neural and Evolutionary Computing · Computer Science 2022-12-09 Francesco Lässig , Pau Vilimelis Aceituno , Martino Sorbaro , Benjamin F. Grewe

While the backpropagation of error algorithm enables deep neural network training, it implies (i) bidirectional synaptic weight transport and (ii) update locking until the forward and backward passes are completed. Not only do these…

Machine Learning · Statistics 2021-01-19 Charlotte Frenkel , Martin Lefebvre , David Bol

Recent advances in deep neural networks (DNNs) owe their success to training algorithms that use backpropagation and gradient-descent. Backpropagation, while highly effective on von Neumann architectures, becomes inefficient when scaling to…

Neural and Evolutionary Computing · Computer Science 2019-05-10 Brian Crafton , Abhinav Parihar , Evan Gebhardt , Arijit Raychowdhury

Stochastic gradient descent with backpropagation is the workhorse of artificial neural networks. It has long been recognized that backpropagation fails to be a biologically plausible algorithm. Fundamentally, it is a non-local procedure --…

Machine Learning · Statistics 2021-12-24 Ganlin Song , Ruitu Xu , John Lafferty

How does the neocortex learn and develop the foundations of all our high-level cognitive abilities? We present a comprehensive framework spanning biological, computational, and cognitive levels, with a clear theoretical continuity between…

Neurons and Cognition · Quantitative Biology 2017-09-15 Randall C. O'Reilly , Dean R. Wyatte , John Rohrlich

We introduce a new method for learning Bayesian neural networks, treating them as a stack of multivariate Bayesian linear regression models. The main idea is to infer the layerwise posterior exactly if we know the target outputs of each…

Machine Learning · Computer Science 2024-11-20 Richard Kurle , Alexej Klushyn , Ralf Herbrich

The neural plausibility of backpropagation has long been disputed, primarily for its use of non-local weight transport $-$ the biologically dubious requirement that one neuron instantaneously measure the synaptic weights of another. Until…

Neurons and Cognition · Quantitative Biology 2020-06-26 Daniel Kunin , Aran Nayebi , Javier Sagastuy-Brena , Surya Ganguli , Jonathan M. Bloom , Daniel L. K. Yamins

Significant success has been reported recently using deep neural networks for classification. Such large networks can be computationally intensive, even after training is over. Implementing these trained networks in hardware chips with a…

Machine Learning · Statistics 2013-10-25 Daniel Soudry , Ron Meir

Skateboards offer a compact and efficient means of transportation as a type of personal mobility device. However, controlling them with legged robots poses several challenges for policy learning due to perception-driven interactions and…

Robotics · Computer Science 2026-04-22 Minsung Yoon , Jeil Jeong , Sung-Eui Yoon

The success of deep neural networks greatly relies on the availability of large amounts of high-quality annotated data, which however are difficult or expensive to obtain. The resulting labels may be class imbalanced, noisy or human biased.…

Machine Learning · Computer Science 2022-06-24 Xiong Zhou , Xianming Liu , Deming Zhai , Junjun Jiang , Xin Gao , Xiangyang Ji

Training deep neural networks on large-scale datasets requires significant hardware resources whose costs (even on cloud platforms) put them out of reach of smaller organizations, groups, and individuals. Backpropagation, the workhorse for…

Machine Learning · Computer Science 2020-09-22 Alexander Ororbia , Ankur Mali , Daniel Kifer , C. Lee Giles

Lifelong learning algorithms enable models to incrementally acquire new knowledge without forgetting previously learned information. Contrarily, the field of machine unlearning focuses on explicitly forgetting certain previous knowledge…

Machine Learning · Computer Science 2025-05-19 Ozan Özdenizci , Elmar Rueckert , Robert Legenstein

Active Learning (AL) promises to reduce annotation cost by prioritizing informative samples, yet its reliability is undermined when labels are noisy or when the data distribution shifts. In practice, annotators make mistakes, rare…

Machine Learning · Computer Science 2025-10-14 Atharv Goel , Sharat Agarwal , Saket Anand , Chetan Arora

Backpropagation is widely used to train artificial neural networks, but its relationship to synaptic plasticity in the brain is unknown. Some biological models of backpropagation rely on feedback projections that are symmetric with…

Neurons and Cognition · Quantitative Biology 2023-02-08 Navid Shervani-Tabar , Robert Rosenbaum

Backpropagation is driving today's artificial neural networks (ANNs). However, despite extensive research, it remains unclear if the brain implements this algorithm. Among neuroscientists, reinforcement learning (RL) algorithms are often…

Neurons and Cognition · Quantitative Biology 2020-04-24 Benjamin James Lansdell , Prashanth Ravi Prakash , Konrad Paul Kording