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Fluorescence lifetime imaging microscopy (FLIM) is a powerful quantitative technique that provides metabolic and molecular contrast, offering strong translational potential for label-free, real-time diagnostics. However, its clinical…

Computer Vision and Pattern Recognition · Computer Science 2025-12-19 Paloma Casteleiro Costa , Parnian Ghapandar Kashani , Xuhui Liu , Alexander Chen , Ary Portes , Julien Bec , Laura Marcu , Aydogan Ozcan

The use of averaging has long been known to reduce noise in statistically independent systems that exhibit similar levels of stochastic fluctuation. This concept of averaging is general and applies to a wide variety of physical and man-made…

For more than a century, the diffraction limit has defined the resolution achievable by passive optical imaging systems. Although some resolution improvement can be gained through classical data processing of the image, it is limited by the…

Quantum Physics · Physics 2026-05-12 A. I. Lvovsky , Michael R. Grace , Saikat Guha , Mankei Tsang , Gerardo Adesso , Nicolas Treps

Radio-frequency phase modulation of frequency entangled photons leads to a two-photon interference pattern in the frequency domain. In recent experiments, the pattern was measured with narrow-band frequency filters which select photons…

The routine atomic-resolution structure determination of single particles is expected to have profound implications for probing the structure-function relationship in systems ranging from energy materials to biological molecules.…

In a variety of fields, in particular those involving imaging and optics, we often measure signals whose phase is missing or has been irremediably distorted. Phase retrieval attempts to recover the phase information of a signal from the…

Information Theory · Computer Science 2019-10-02 Gilles Baechler , Miranda Kreković , Juri Ranieri , Amina Chebira , Yue M. Lu , Martin Vetterli

In deep tissue photoacoustic imaging, the spatial resolution is inherently limited by acoustic diffraction. Moreover, as the ultrasound attenuation increases with frequency, resolution is often traded-off for penetration depth. Here we…

We address the issue of visual saliency from three perspectives. First, we consider saliency detection as a frequency domain analysis problem. Second, we achieve this by employing the concept of {\it non-saliency}. Third, we simultaneously…

Computer Vision and Pattern Recognition · Computer Science 2016-05-09 Jian Li , Martin Levine , Xiangjing An , Xin Xu , Hangen He

Super-Resolution (SR) is a technique that seeks to upscale the resolution of a set of measured signals. SR retrieves higher-frequency signal content by combining multiple lower resolution sampled data sets. SR is well known both in the…

Instrumentation and Methods for Astrophysics · Physics 2022-11-09 Sylvain Oberti , Carlos Correia , Thierry Fusco , Benoit Neichel , Pierre Guiraud

One of the challenges in hyperspectral data analysis is the presence of mixed pixels. Mixed pixels are the result of low spatial resolution of hyperspectral sensors. Spectral unmixing methods decompose a mixed pixel into a set of endmembers…

Computer Vision and Pattern Recognition · Computer Science 2015-06-05 Roozbeh Rajabi , Hassan Ghassemian

We fabricated thin-films made from polydimethylsiloxane (PDMS) with embedded high-index (n~1.9-2.2) microspheres for super-resolution imaging applications. To control the position of microspheres, such films can be translated along the…

Advances in optical imaging always look for an increase in sensitivity and resolution among other practicability aspects. Within the same scope, in this work we report a versatile interference contrast imaging technique, capable of sub-nm…

Interferometers are widely used in imaging technologies to achieve enhanced spatial resolution, but require that the incoming photons be indistinguishable. In previous work, we built and analyzed color erasure detectors which expand the…

We study super-resolution imaging theoretically using a distant n-mode interferometer in the microwave regime for passive remote sensing, used e.g., for satellites like the "soil moisture and ocean salinity (SMOS)" mission to observe the…

Quantum Physics · Physics 2023-03-29 Emre Köse , Daniel Braun

The ultimate detection limit of optical biosensors is often limited by various noise sources, including those introduced by the optical measurement setup. While sophisticated modifications to instrumentation may reduce noise, a simpler…

Signal Processing · Electrical Eng. & Systems 2021-09-07 Simon J. Ward , Rabeb Layouni , Sofia Arshavsky-Graham , Ester Segal , Sharon M. Weiss

We present the results of the characterization of novel n-in-p planar pixel detectors, designed for the future upgrades of the ATLAS pixel system. N-in-p silicon devices are a promising candidate to replace the n-in-n sensors thanks to…

Instrumentation and Detectors · Physics 2012-03-01 A. Macchiolo , C. Gallrapp , A. La Rosa , R. Nisius , H. Pernegger , R. H. Richter , P. Weigell

Optical stellar interferometers have demonstrated milli-arcsecond resolution with few apertures spaced hundreds of meters apart. To obtain rich direct images, many apertures will be needed, for a better sampling of the incoming wavefront.…

Instrumentation and Methods for Astrophysics · Physics 2014-09-17 Arun Surya , Swapan K. Saha , Antoine Labeyrie

Laser-frequency stabilization with on-chip photonic integrated circuits will provide compact, low cost solutions to realize spectrally pure laser sources. Developing high-performance and scalable lasers is critical for applications…

Non-line-of-sight (NLOS) imaging enables monitoring around corners and is promising for diverse applications. The resolution of transient NLOS imaging is limited to a centimeter scale, mainly by the temporal resolution of the detectors.…

A lensless digital holography enables wide-field microscopic imaging without the limitations imposed by optical lens performance. However, conventional holographic imaging often relies on magnifying optical systems to compensate for the low…

Optics · Physics 2025-06-24 Byung Gyu Chae
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