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The mortality of lung cancer has ranked high among cancers for many years. Early detection of lung cancer is critical for disease prevention, cure, and mortality rate reduction. However, existing detection methods on pulmonary nodules…

Image and Video Processing · Electrical Eng. & Systems 2022-05-13 Juanyun Mai , Minghao Wang , Jiayin Zheng , Yanbo Shao , Zhaoqi Diao , Xinliang Fu , Yulong Chen , Jianyu Xiao , Jian You , Airu Yin , Yang Yang , Xiangcheng Qiu , Jinsheng Tao , Bo Wang , Hua Ji

Lung cancer has the highest mortality rate of deadly cancers in the world. Early detection is essential to treatment of lung cancer. However, detection and accurate diagnosis of pulmonary nodules depend heavily on the experiences of…

Image and Video Processing · Electrical Eng. & Systems 2022-04-12 Chenglong Wang , Yun Liu , Fen Wang , Chengxiu Zhang , Yida Wang , Mei Yuan , Guang Yang

In this work, we present a fully automated lung computed tomography (CT) cancer diagnosis system, DeepLung. DeepLung consists of two components, nodule detection (identifying the locations of candidate nodules) and classification…

Computer Vision and Pattern Recognition · Computer Science 2018-01-30 Wentao Zhu , Chaochun Liu , Wei Fan , Xiaohui Xie

Candidate generation, the first stage for most computer aided detection (CAD) systems, rapidly scans the entire image data for any possible abnormality locations, while the subsequent stages of the CAD system refine the candidates list to…

Image and Video Processing · Electrical Eng. & Systems 2019-07-22 Sergei V. Fotin , David F. Yankelevitz , Claudia I. Henschke , Anthony P. Reeves

In this work, we present a fully automated lung CT cancer diagnosis system, DeepLung. DeepLung contains two parts, nodule detection and classification. Considering the 3D nature of lung CT data, two 3D networks are designed for the nodule…

Computer Vision and Pattern Recognition · Computer Science 2017-09-19 Wentao Zhu , Chaochun Liu , Wei Fan , Xiaohui Xie

Microscopy imaging techniques are instrumental for characterization and analysis of biological structures. As these techniques typically render 3D visualization of cells by stacking 2D projections, issues such as out-of-plane excitation and…

Image and Video Processing · Electrical Eng. & Systems 2023-02-16 Amirkoushyar Ziabari , Derek C. Rose , Abbas Shirinifard , David Solecki

Recent studies have shown that lung cancer screening using annual low-dose computed tomography (CT) reduces lung cancer mortality by 20% compared to traditional chest radiography. Therefore, CT lung screening has started to be used widely…

Computer Vision and Pattern Recognition · Computer Science 2018-11-06 Gorkem Polat , Ugur Halici , Yesim Serinagaoglu Dogrusoz

Lung nodule classification is a class imbalanced problem, as nodules are found with much lower frequency than non-nodules. In the class imbalanced problem, conventional classifiers tend to be overwhelmed by the majority class and ignore the…

Computer Vision and Pattern Recognition · Computer Science 2017-12-19 Masaharu Sakamoto , Hiroki Nakano , Kun Zhao , Taro Sekiyama

A computer-aided detection (CAD) system for the identification of lung internal nodules in low-dose multi-detector helical Computed Tomography (CT) images was developed in the framework of the MAGIC-5 project. The three modules of our lung…

Recent studies have shown that lung cancer screening using annual low-dose computed tomography (CT) reduces lung cancer mortality by 20% compared to traditional chest radiography. Therefore, CT lung screening has started to be used widely…

Image and Video Processing · Electrical Eng. & Systems 2021-07-13 Gorkem Polat , Yesim Dogrusoz Serinagaoglu , Ugur Halici

Lung nodules suffer large variation in size and appearance in CT images. Nodules less than 10mm can easily lose information after down-sampling in convolutional neural networks, which results in low sensitivity. In this paper, a combination…

Computer Vision and Pattern Recognition · Computer Science 2018-08-02 Benyuan Sun , Zhen Zhou , Fandong Zhang , Xiuli Li , Yizhou Wang

Purpose: In recent years, Non-Local based methods have been successfully applied to lung nodule classification. However, these methods offer 2D attention or limited 3D attention to low-resolution feature maps. Moreover, they still depend on…

Image and Video Processing · Electrical Eng. & Systems 2021-06-02 Mundher Al-Shabi , Kelvin Shak , Maxine Tan

Recently, Computer-Aided Diagnosis (CAD) systems have emerged as indispensable tools in clinical diagnostic workflows, significantly alleviating the burden on radiologists. Nevertheless, despite their integration into clinical settings, CAD…

Image and Video Processing · Electrical Eng. & Systems 2024-06-27 Muwei Jian , Hongyu Chen , Zaiyong Zhang , Nan Yang , Haorang Zhang , Lifu Ma , Wenjing Xu , Huixiang Zhi

Computed tomography (CT) generates a stack of cross-sectional images covering a region of the body. The visual assessment of these images for the identification of potential abnormalities is a challenging and time consuming task due to the…

Machine Learning · Statistics 2016-10-03 Petros-Pavlos Ypsilantis , Giovanni Montana

Dense annotations, such as segmentation masks, are expensive and time-consuming to obtain, especially for 3D medical images where expert voxel-wise labeling is required. Weakly supervised approaches aim to address this limitation, but often…

Computer Vision and Pattern Recognition · Computer Science 2026-04-21 Richard Petersen , Fredrik Kahl , Jennifer Alvén

Lung cancer ranks as one of the leading causes of cancer diagnosis and is the foremost cause of cancer-related mortality worldwide. The early detection of lung nodules plays a pivotal role in improving outcomes for patients, as it enables…

Computer Vision and Pattern Recognition · Computer Science 2025-10-28 Jiasen Zhang , Mingrui Yang , Weihong Guo , Brian A. Xavier , Michael Bolen , Xiaojuan Li

Lung cancer is a global and dangerous disease, and its early detection is crucial to reducing the risks of mortality. In this regard, it has been of great interest in developing a computer-aided system for pulmonary nodules detection as…

Computer Vision and Pattern Recognition · Computer Science 2018-07-30 Bum-Chae Kim , Jun-Sik Choi , Heung-Il Suk

Early detection of lung nodules with computed tomography (CT) is critical for the longer survival of lung cancer patients and better quality of life. Computer-aided detection/diagnosis (CAD) is proven valuable as a second or concurrent…

Computer Vision and Pattern Recognition · Computer Science 2022-10-19 Chuang Niu , Ge Wang

Nodule malignancy assessment is a complex, time-consuming and error-prone task. Current clinical practice requires measuring changes in size and density of the nodule at different time-points. State of the art solutions rely on 3D…

Image and Video Processing · Electrical Eng. & Systems 2020-05-27 Xavier Rafael-Palou , Anton Aubanell , Ilaria Bonavita , Mario Ceresa , Gemma Piella , Vicent Ribas , Miguel A. González Ballester

Evaluation of artificial intelligence (AI) models for low-dose CT lung cancer screening is limited by heterogeneous datasets, annotation standards, and evaluation protocols, making performance difficult to compare and translate across…

Computer Vision and Pattern Recognition · Computer Science 2026-02-10 Fakrul Islam Tushar , Avivah Wang , Lavsen Dahal , Ehsan Samei , Michael R. Harowicz , Jayashree Kalpathy-Cramer , Kyle J. Lafata , Tina D. Tailor , Cynthia Rudin , Joseph Y. Lo