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Hierarchical data with multiple observations per group is ubiquitous in empirical sciences and is often analyzed using mixed-effects regression. In such models, Bayesian inference gives an estimate of uncertainty but is analytically…

Machine Learning · Computer Science 2026-02-05 Alex Kipnis , Marcel Binz , Eric Schulz

This paper introduces a novel approach for estimating heterogeneous treatment effects of binary treatment in panel data, particularly focusing on short panel data with large cross-sectional data and observed confoundings. In contrast to…

Methodology · Statistics 2024-06-05 Meijia Wang , Ignacio Martinez , P. Richard Hahn

Training complex machine learning models for prediction often requires a large amount of data that is not always readily available. Leveraging these external datasets from related but different sources is therefore an important task if good…

Machine Learning · Computer Science 2018-06-11 Jinsung Yoon , James Jordon , Mihaela van der Schaar

The large-scale multiple testing inherent to high throughput biological data necessitates very high statistical stringency and thus true effects in data are difficult to detect unless they have high effect sizes. One solution to this…

Methodology · Statistics 2017-12-21 Mohamad S. Hasan

When estimating a regression model, we might have data where some labels are missing, or our data might be biased by a selection mechanism. When the response or selection mechanism is ignorable (i.e., independent of the response variable…

Statistics Theory · Mathematics 2023-08-22 Philip Boeken , Noud de Kroon , Mathijs de Jong , Joris M. Mooij , Onno Zoeter

An important problem in the analysis of high-dimensional omics data is to identify subsets of molecular variables that are associated with a phenotype of interest. This requires addressing the challenges of high dimensionality, strong…

Methodology · Statistics 2022-04-05 Fan Wang , Sylvia Richardson , Steven M. Hill

Probe-level models have led to improved performance in microarray studies but the various sources of probe-level contamination are still poorly understood. Data-driven analysis of probe performance can be used to quantify the uncertainty in…

Computational Engineering, Finance, and Science · Computer Science 2013-04-09 Leo Lahti , Laura L. Elo , Tero Aittokallio , Samuel Kaski

Multi-parameter regression (MPR) modelling refers to the approach whereby covariates are allowed to enter the model through multiple distributional parameters simultaneously. This is in contrast to the standard approaches where covariates…

Methodology · Statistics 2019-07-03 Fatima-Zahra Jaouimaa , Il Do Ha , Kevin Burke

Penalized B-splines are routinely used in additive models to describe smooth changes in a response with quantitative covariates. It is typically done through the conditional mean in the exponential family using generalized additive models…

Methodology · Statistics 2020-05-12 Philippe Lambert

We consider regression in which one predicts a response $Y$ with a set of predictors $X$ across different experiments or environments. This is a common setup in many data-driven scientific fields and we argue that statistical inference can…

Methodology · Statistics 2026-03-23 Niklas Pfister , Evan G. Williams , Jonas Peters , Ruedi Aebersold , Peter Bühlmann

Including prior information about model parameters is a fundamental step of any Bayesian statistical analysis. It is viewed positively by some as it allows, among others, to quantitatively incorporate expert opinion about model parameters.…

Methodology · Statistics 2023-08-22 Philippe Gagnon

We extend the correspondence between two-stage coding procedures in data compression and penalized likelihood procedures in statistical estimation. Traditionally, this had required restriction to countable parameter spaces. We show how to…

Statistics Theory · Mathematics 2015-05-08 Sabyasachi Chatterjee , Andrew Barron

Sparse regularized regression methods are now widely used in genome-wide association studies (GWAS) to address the multiple testing burden that limits discovery of potentially important predictors. Linear mixed models (LMMs) have become an…

Methodology · Statistics 2022-06-27 Julien St-Pierre , Karim Oualkacha , Sahir Rai Bhatnagar

The regsem package in R, an implementation of regularized structural equation modeling (RegSEM; Jacobucci, Grimm, and McArdle 2016), was recently developed with the goal of incorporating various forms of penalized likelihood estimation in a…

Methodology · Statistics 2017-09-11 Ross Jacobucci

Transfer learning has become an essential technique to exploit information from the source domain to boost performance of the target task. Despite the prevalence in high-dimensional data, heterogeneity and heavy tails are insufficiently…

Machine Learning · Statistics 2023-11-07 Jiayu Huang , Mingqiu Wang , Yuanshan Wu

Any reinforcement learning system must be able to identify which past events contributed to observed outcomes, a problem known as credit assignment. A common solution to this problem is to use an eligibility trace to assign credit to…

Machine Learning · Computer Science 2022-07-26 Duncan Bailey , Marcelo G. Mattar

This paper studies policy evaluation with multiple data sources, especially in scenarios that involve one experimental dataset with two arms, complemented by a historical dataset generated under a single control arm. We propose novel data…

Machine Learning · Statistics 2024-06-04 Ting Li , Chengchun Shi , Qianglin Wen , Yang Sui , Yongli Qin , Chunbo Lai , Hongtu Zhu

In recent years, there has been considerable theoretical development regarding variable selection consistency of penalized regression techniques, such as the lasso. However, there has been relatively little work on quantifying the…

Methodology · Statistics 2014-05-21 Arend Voorman , Ali Shojaie , Daniela Witten

Data integration methods aim to extract low-dimensional embeddings from high-dimensional outcomes to remove unwanted variations, such as batch effects and unmeasured covariates, across heterogeneous datasets. However, multiple hypothesis…

Methodology · Statistics 2025-12-15 Jin-Hong Du , Kathryn Roeder , Larry Wasserman

This work is motivated by analyses of longitudinal data collected from participants in the Quebec Longitudinal Study of Child Development (QLSCD) and the Quebec Newborn Twin Study (QNTS) to identify important genetic predictors for…